Fabien Gagnon

Generalized anxiety disorder: a preliminary test of a conceptual model

This study presents a preliminary test of a conceptual model of Generalized Anxiety Disorder (GAD) which is theoretically driven and has clear clinical implications. The models main features are intolerance of uncertainty, beliefs about worry, poor problem orientation and cognitive avoidance, Subjects were 24 GAD patients and 20 non clinical control subjects. The results show that all main components of the model were highly related to the discriminant function and that intolerance of uncertainty was pivotal in distinguishing GAD patients from non clinical subjects. Further, the discriminant function derived from these four process variables was very effective for classifying GAD patients and non clinical subjects into their respective groups. Overall, 82% of subjects were correctly classified as 18 of 24 subjects in the GAD group and 18 of 20 subjects in the non clinical group were properly identified. The results are discussed in terms of the proposed model of GAD and its clinical implications.

Efficacy of a cognitive-behavioral treatment for generalized anxiety disorder : Evaluation in a controlled clinical trial

Recent advances in the understanding of worry have led to the development of treatments for generalized anxiety disorder (GAD). The present study tested a GAD treatment that targeted intolerance of uncertainty, erroneous beliefs about worry, poor problem orientation, and cognitive avoidance. Twenty-six primary GAD patients were randomly allocated to a treatment condition (n = 14) or a delayed treatment control condition (n = 12). Self-report, clinician, and significant other ratings assessed GAD and associated symptoms. The results show that the treatment led to statistically and clinically significant change at posttest and that gains were maintained at 6- and 12-month follow-ups. Furthermore, 20 of 26 participants (77%) no longer met GAD diagnostic criteria following treatment. With regard to the treatments underlying model, the results show that intolerance of uncertainty significantly decreased over treatment and that gains were maintained at both follow-ups. Although nonspecific factors were not significant predictors of treatment outcome, their role in the treatment of GAD requires further investigation.

Cognitive—behavioral treatment of obsessive thoughts: A controlled study.

Twenty-nine patients with obsessive-compulsive disorder as diagnosed in accordance with the Diagnostic and Statistical Manual of Mental Disorders (3rd ed., revised; American Psychiatric Association, 1987) who did not have overt compulsive rituals were randomly assigned to treatment and waiting-list conditions. Patients in the treatment condition received cognitive-behavioral therapy consisting of a detailed explanation of the occurrence and maintenance of obsessive thoughts, exposure to obsessive thoughts, response prevention of all neutralizing strategies, cognitive restructuring, and relapse prevention. Compared with waiting-list patients, treated patients improved significantly on measures of severity of obsessions, current functioning, self-report obsessive-compulsive symptoms, and anxiety. When waiting-list patients were subsequently treated, the combined group improved on all outcome measures. Treatment gains were maintained at 6-month follow-up. Results indicate that cognitive-behavioral therapy is effective in the treatment of patients with obsessive thoughts, a group that has often been considered resistant to treatment.

Specificity of generalized anxiety disorder symptoms and processes

This studys main goal is to test the broad specificity of generalized anxiety disorder (GAD) symptom and process variables. These variables were compared in four groups of participants: (1) 24 patients with primary GAD, (2) 24 patients with secondary GAD, (3) 38 other anxiety disorder patients, and (4) 20 nonclinical control subjects. Each participant received a structured diagnostic interview and a series of standardized questionnaires. The results show that DSM-IV GAD symptoms (worry, GAD physical symptoms, and interference due to worry and anxiety) distinguish GAD patients from those with other anxiety disorders. Two process variables, problem orientation and intolerance of uncertainty, also differentiated GAD patients from other anxiety disorder patients. Overall, these results support the DSM-IV definition of GAD and the broad specificity of problem orientation and intolerance of uncertainty as GAD process variables.

Beliefs about obsessional thoughts

Recent cognitive-behavioral formulations of obsessive-compulsive disorder postulate that intrusive or obsessional thoughts are subject to appraisal. Extreme beliefs about the occurrence and meaning of intrusive thoughts direct appraisal, thus causing marked distress and subjective responsibility which may lead to neutralizing activity. A brief self-report belief inventory was developed from a 92-item pool to assess extreme beliefs concerning intrusive thoughts and responsibility, the control of such thoughts and their possible consequences, and the appropriateness of guilt and neutralizing behavior as a response. The inventory was developed sequentially on two nonclinical samples (N=125, N=265) to distinguish between neutralizing and nonneutralizing subjects. Initial psychometric data for the final instrument were obtained for two further nonclinical samples (N=61, N=50) along with a sample of OCD patients and a matched control group. The instrument showed satisfactory reliability and evidence of criterion, convergent, discriminant, and factorial validity. Finally, data from a heterogeneous outpatient medical sample (N=299) was used to test the relationship among obsessive-compulsive symptoms, mood state, and beliefs. The implications of these results for contemporary models of obsessive-compulsive disorder are discussed.

Self-report of obsessions and worry

The relationships between self-reported worry and obsessional-compulsive symptoms were examined among 145 hospital outpatients. Subjects completed the Penn State Worry Questionnaire and the Padua Inventory. Despite moderately strong correlations, the scales measured distinct constructs. Eliminating five items from the Padua Inventory may improve its discriminant validity. Correlations with the Padua Inventory subscales showed that obsessional loss of mental control was moderately correlated to both worry and checking, whereas worry and checking were only weakly correlated. The results are discussed in terms of possible relationships between worry and obsessions.

Cognitive-Behavioral Treatment of Obsessions

Three patients with obsessive-compulsive disorder whose major complaints were obsessional thoughts with cognitive neutralization as opposed to overt rituals were treated with a cognitive-behavioral package. Cognitive neutralization involves both cognitive rituals and a variety of less ritualized coping strategies all designed to remove the thought and decrease discomfort. In a departure from earlier case studies, the patients were treated in a multiple baseline design across subjects. All three patients reported decreased discomfort and improved theirprofessional and/or interpersonal functioning. Gains were maintained at follow-up (8 to 11 months).

Idiographic considerations in the behavioral treatment of obsessional thoughts

Despite impressive improvement in the behavioral treatment of obsessive-compulsive disorder over the last 15 years, progress has been slower for obsessional thoughts with few or no overt rituals. Encouraging case reports suggest that exposure to obsessional thoughts combined with covert response prevention is an effective treatment. Three cases are presented that required adaptation from the guidelines laid out by Salkovskis and Westbrook (1989). They provide clear evidence of the need to adopt a creative and flexible approach to exposure that enables access and activation of fear structures.

Health-related intrusive thoughts☆

Two studies address the prevalence, concomitants, and appraisal of health-related intrusive thoughts. Eighty-three percent of adults (N = 658) in waiting rooms of two general hospitals reported at least one intrusive thought during the preceding month and 75.0% of patients and 55.5% of people accompanying them reported a health-related intrusive thought in the same period. The intrusions were associated with anxious and depressive symptoms. Health related intrusive thoughts were reported by 61% of a sample of university students (N = 608) and were the most frequent intrusive thought among 19.9% of the students. First, triggering stimuli reported by the subjects were significant predictors of thought frequency, worry, removal difficulty, and effort used in removing the thought. Second, appraisals of high probability were significant predictors of high frequency, worry, and especially difficulty in removing the thought. Finally, perceived responsibility and disapproval of the thought were also significant predictors of thought frequency, worry, removal difficulty, effort used in removing the thought, and guilt. These data support the position that cognitive appraisal of intrusive thoughts is closely linked to the subjective experience of the thought: more extreme appraisals were associated with more troublesome thoughts. The clinical implications of these studies are discussed in terms of current models of hypochondriasis and health anxiety.

Assessment of the effectiveness of radon screening programs in reducing lung cancer mortality.

The present study was aimed at assessing the health consequences of the presence of radon in Quebec homes and the possible impact of various screening programs on lung cancer mortality. Lung cancer risk due to this radioactive gas was estimated according to the cancer risk model developed by the Sixth Committee on Biological Effects of Ionizing Radiations. Objective data on residential radon exposure, population mobility, and tobacco use in the study population were integrated into a Monte-Carlo-type model. Participation rates to radon screening programs were estimated from published data. According to the model used, approximately 10% of deaths due to lung cancer are attributable to residential radon exposure on a yearly basis in Quebec. In the long term, the promotion of a universal screening program would prevent less than one death/year on a province-wide scale (0.8 case; IC 99%: -3.6 to 5.2 cases/year), for an overall reduction of 0.19% in radon-related mortality. Reductions in mortality due to radon by (1) the implementation of a targeted screening program in the region with the highest concentrations, (2) the promotion of screening on a local basis with financial support, or (3) the realization of systematic investigations in primary and secondary schools would increase to 1%, 14%, and 16.4%, respectively, in the each of the populations targeted by these scenarios. Other than the battle against tobacco use, radon screening in public buildings thus currently appears as the most promising screening policy for reducing radon-related lung cancer.