Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where Fabio Ziarelli is active.

Publication


Featured researches published by Fabio Ziarelli.


Environmental Science & Technology | 2010

Structural Degradation at the Surface of a TiO2-Based Nanomaterial Used in Cosmetics

Mélanie Auffan; Maxime Pedeutour; J. Rose; Armand Masion; Fabio Ziarelli; Daniel Borschneck; Corinne Chanéac; Céline Botta; Perrine Chaurand; J. Labille; Jean-Yves Bottero

A number of commercialized nanomaterials incorporate TiO(2) nanoparticles. Studying their structural stability in media mimicking the environment or the conditions of use is crucial in understanding their potential eco-toxicological effects. We focused here on a hydrophobic TiO(2) nanoparticle-based formulation used in cosmetics: T-Lite SF. It is composed of a TiO(2) core, coated with two successive protective layers of Al(OH)(3), and polydimethylsiloxane. Soon after contact with water (pH = 5, low ionic strength), the T-Lite SF becomes hydrophilic and form aggregates. During this aging, 90%wt of the total Si of the organic layer is desorbed, and the PDMS remaining at the surface is oxidized. The Al(OH)(3) layer is also affected but remains sorbed at the surface. This remaining Al-based layer still protects from the production of superoxide ions from the photoactive/phototoxic TiO(2) core in our experimental conditions.


Chemical Society Reviews | 2013

19F NMR: a valuable tool for studying biological events.

Han Chen; Stéphane Viel; Fabio Ziarelli; Ling Peng

With the spectacular advancement of NMR techniques and the flourishing of fluorine chemistry allowing the synthesis of various fluorinated molecules, (19)F NMR represents a compelling option for studying myriad biological events ranging from the structure and function of biomolecules, enzymatic mechanisms, and metabolic pathways, through to drug screening and discovery as well as medical imaging. In this tutorial review, we aim to provide readers with a brief overview of the recent applications of (19)F NMR in various areas relating to biological and biomedical research, together with a brief introduction of specific hardware improvements permitting the practical implementation of (19)F NMR.


Langmuir | 2009

Hydration and Dispersion of C60 in Aqueous Systems: The Nature of Water−Fullerene Interactions

J. Labille; Armand Masion; Fabio Ziarelli; J. Rose; Jonathan A. Brant; Frédéric Villiéras; Manuel Pelletier; Daniel Borschneck; Mark R. Wiesner; Jean-Yves Bottero

The nature of fullerene-water interactions and the role that they play in the fate of C60 in aqueous systems is poorly understood. This work provides spectroscopic evidence for the surface hydroxylation of the initially hydrophobic C60 molecule when immersed in water. This mechanism appears to be the basis for stabilizing the hydrophilic nC60 aggregates in suspension. It is remarkable that such a chemical transformation and dispersion are achieved under mild conditions that are readily produced in an aquatic environment. This acquired affinity for water is likely to play a subsequent role in the reactivity, mobility, and bioavailability of fullerenes in aqueous media.


Proceedings of the National Academy of Sciences of the United States of America | 2003

Enhanced diffusion-edited NMR spectroscopy of mixtures using chromatographic stationary phases

Stéphane Viel; Fabio Ziarelli; Stefano Caldarelli

We introduce an analytical method that combines in one pot the advantages of column chromatography separation and NMR structural analysis. The separation of the NMR spectra of the components of a mixture can be achieved according to their apparent diffusion rates [James, T. L. and McDonald, G. G. (1973) J. Magn. Reson. 58, 58–61]. We show that the separation of the spectral components, corresponding to single molecular species, can be enhanced by order of magnitudes upon addition of a typical stationary phase used in HPLC. The solid phase imbibed by the mixture for analysis is an heterogeneous ensemble, so that solid-state NMR methods (high-resolution magic angle spinning) are necessary to recover high-resolution spectra. We demonstrate applications of this combination of high-resolution magic angle spinning and NMR diffusometry on test mixtures for direct (silica gel) and inverse (C18) columns. However, many common chromatographic supports available for HPLC should be readily adaptable for use with this technique.


Bioconjugate Chemistry | 2011

Structurally Flexible Triethanolamine Core PAMAM Dendrimers Are Effective Nanovectors for DNA Transfection in Vitro and in Vivo to the Mouse Thymus

Xiaoxuan Liu; Jiangyu Wu; Miriam Yammine; Jiehua Zhou; Paola Posocco; Stéphane Viel; Cheng Liu; Fabio Ziarelli; Maurizio Fermeglia; Sabrina Pricl; Geneviève Victorero; Catherine Nguyen; Patrick Erbacher; Jean-Paul Behr; Ling Peng

With the aim of developing dendrimer nanovectors with a precisely controlled architecture and flexible structure for DNA transfection, we designed PAMAM dendrimers bearing a triethanolamine (TEA) core, with branching units pointing away from the center to create void spaces, reduce steric congestion, and increase water accessibility for the benefit of DNA delivery. These dendrimers are shown to form stable nanoparticles with DNA, promote cell uptake mainly via macropinocytosis, and act as effective nanovectors for DNA transfection in vitro on epithelial and fibroblast cells and, most importantly, in vivo in the mouse thymus, an exceedingly challenging organ for immune gene therapy. Collectively, these results validate our rational design approach of structurally flexible dendrimers with a chemically defined structure as effective nanovectors for gene delivery, and demonstrate the potential of these dendrimers in intrathymus gene delivery for future applications in immune gene therapy.


Journal of the American Chemical Society | 2010

CO2 Binding by Dynamic Combinatorial Chemistry: An Environmental Selection

Julien Leclaire; Guillaume Husson; Nathalie Devaux; Vincent Delorme; Laurence Charles; Fabio Ziarelli; Perrine Desbois; Alexandra Chaumonnot; Marc Jacquin; Frédéric Fotiadu; Gérard Buono

We now report that a dynamic combinatorial selection approach can quantitatively provide, from trivial building blocks, an architecturally complex organic material, in which carbon dioxide is reversibly but covalently incorporated as a guest with a mass content of 20%. Solid-state analyses combined with covalent disconnection and quantization of the liberated components allowed identification of a three-component monomeric unit repeated within a range of assembled oligomeric adducts whose repartition and binding capacity can be finely tuned through the starting stoichiometries. The self-assembly of these architectures occurs through the simultaneous creation of more than 25 covalent bonds per molecular entity. It appears that the thermodynamic selection is directed by the packing efficiency of these adducts, explaining the spectacular building block discrimination between homologues differing by one carbon unit. This selectivity, combined with the reversible nature of the system, provided pure molecular building blocks after a simple chemical disconnection, promoting CO(2) as a green auxiliary to purify polyaldehyde or polyamine from mixtures of homologous structures. Moreover, the gas template could be expelled as a pure compound under thermodynamic control. This cooperative desorption process yielded back the initial libraries of high molecular diversity with a promising reduction of the energetic costs of capture and recycling.


Chemical Physics Letters | 2003

Increasing the robustness of heteronuclear decoupling in magic-angle sample spinning solid-state NMR

Guillaume Gerbaud; Fabio Ziarelli; Stefano Caldarelli

Proton decoupling is a crucial step to obtain high-resolution NMR spectra of macromolecules. Current methods employ phase (or amplitude)-modulated radio-frequency pulses to this end. To be effective, the modulation has to match some resonant condition. We demonstrate in this Communication a simple approach to expand the stability of the resonant condition by convolution of the basic modulation with a Gaussian envelope.


Environmental Pollution | 2014

Long-term aging of a CeO2 based nanocomposite used for wood protection

Mélanie Auffan; Armand Masion; Jérôme Labille; Marie-Ange Diot; Wei Liu; Luca Olivi; Olivier Proux; Fabio Ziarelli; Perrine Chaurand; Christophe Geantet; Jean Yves Bottero; Jérôme Rose

A multi-scale methodology was used to characterize the long-term behavior and chemical stability of a CeO2-based nanocomposite used as UV filter in wood stains. ATR-FTIR and (13)C NMR demonstrated that the citrate coated chelates with Ce(IV) through its central carboxyl- and its α-hydroxyl- groups at the surface of the unaged nanocomposite. After 42 days under artificial daylight, the citrate completely disappeared and small amount of degradation products remained attached to the surface even after 112 days. Moreover, the release/desorption of the citrate layer led to a surface reorganization of the nano-sized CeO2 core observed by XANES (Ce L3-edge). Such a surface and structural transformation of the commercialized nanocomposite could have implications in term of fate, transport, and potential impacts towards the environment.


Angewandte Chemie | 2015

Quantitative Structural Constraints for Organic Powders at Natural Isotopic Abundance Using Dynamic Nuclear Polarization Solid‐State NMR Spectroscopy

Giulia Mollica; Myriam Dekhil; Fabio Ziarelli; Pierre Thureau; Stéphane Viel

A straightforward method is reported to quantitatively relate structural constraints based on (13)C-(13)C double-quantum build-up curves obtained by dynamic nuclear polarization (DNP) solid-state NMR to the crystal structure of organic powders at natural isotopic abundance. This method relies on the significant gain in NMR sensitivity provided by DNP (approximately 50-fold, lowering the experimental time from a few years to a few days), and is sensitive to the molecular conformation and crystal packing of the studied powder sample (in this case theophylline). This method allows trial crystal structures to be rapidly and effectively discriminated, and paves the way to three-dimensional structure elucidation of powders through combination with powder X-ray diffraction, crystal-structure prediction, and density functional theory computation of NMR chemical shifts.


Journal of Magnetic Resonance | 2008

General implementation of the ERETIC method for pulsed field gradient probe heads.

Fabio Ziarelli; Stéphane Viel; Stefano Caldarelli; Daniel N. Sobieski; Matthew P. Augustine

A capacitive coupling between a secondary radiofrequency (rf) channel and the gradient coil of a standard commercially available high resolution NMR spectrometer and probe head is described and used to introduce a low level exponentially damped rf signal near the frequency of the primary rf channel to serve as an external concentration standard, in analogy to the so-called ERETIC method. The stability of this inexpensive and simple to implement method, here referred to as the Pulse Into the Gradient (PIG) approach, is superb over a 14-h period and both gradient tailored water suppression and one-dimensional imaging applications are provided. Since the low level signal is introduced via the pulsed field gradient coil, the coupling is identical to that for a free induction signal and thus the method proves to be immune (within 5%) to sample ionic strength effects up to the 2M NaCl solutions explored here.

Collaboration


Dive into the Fabio Ziarelli's collaboration.

Top Co-Authors

Avatar

Stéphane Viel

Aix-Marseille University

View shared research outputs
Top Co-Authors

Avatar

Armand Masion

Aix-Marseille University

View shared research outputs
Top Co-Authors

Avatar

Ling Peng

Aix-Marseille University

View shared research outputs
Top Co-Authors

Avatar

Pierre Thureau

Aix-Marseille University

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar

Giulia Mollica

Aix-Marseille University

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar

Didier Gigmes

Aix-Marseille University

View shared research outputs
Top Co-Authors

Avatar
Researchain Logo
Decentralizing Knowledge