Faridul Islam

Comparative Studies on Antidiabetic effect with phytochemical screening of Azadirachta indicia and Andrographis paniculata

The present study was undertaken to evaluate the antidiabetic properties with phytochemical screening of the ethanol leaves extracts of two common indigenous medicinal plants of Bangladesh -Azadirachta indica (Neem) and Andrographis peniculata (Kalomegh) on experimental animal model. Hypoglycemic activity of the concentrated ethanolic (90%) extract of Azadirachta indica and Andrographis peniculata were studied compared with that of a reference antidiabetic drug glimeperide in both glucose loaded and alloxan induced diabetic rats. The acute toxicity of these two plants extract was also studied. Experimental results showed that ethanol leaves extract (1 gm/kg) of Azadirachta indica and Andrographis peniculata significantly (P<0.01) reduced the elevated blood glucose level by 36.91 % and 40.65 % respectively in glucose loaded rats and 30.20 % and 32.18 % respectively in alloxan induced diabetic rats compared to the respective diabetic control group. This study strongly suggested that ethanol leaves extracts of Azadirachta indica and Andrographis peniculata possess significant antidiabetic activity and could be a potential source for treatment of diabetes mellitus.

Heavy Metal Concentration in Some Common Spices Available at Local Market as well as Branded Spicy in Chittagong Metropolitan City, Bangladesh

A study has been conducted to evaluate some heavy metals concentration of spicy from local market of Chittagong metropolitan city, Bangladesh. Total 30 spicy samples of red chili or chili red, coriander, turmeric were collected from five different spots (Khatungonj, Chakbazar, Muradpur, Baluchora, Amanbazar) under Chittagong metropolitan city and metals as Zn, Cu, Cr, Mn, Fe concentration were measured. Metal concentration in red chili, coriander, turmeric were found as increasing order as Cu Khatungonj >Muradpur >Baluchora >Amanbazar, Khatungonj >Chakbazar >Amanbazar >Muradpur >Baluchora, Khatungonj >Chakbazar >Baluchora >Amanbazar >Muradpur, Khatungonj >Chakbazar >Muradpur >Amanbazar >Baluchora, Khatungonj >Chakbazar > Baluchora >Amanbazar >Muradpur respectively. So, spicy of Khatungonj was the highly contaminated with metal followed by chakbazar spicy and least metal concentrated spicy was in Amanbazar at Chittagong city. According to WHO (World Health Organization), Cr and Fe concentrations exceeded the permissible limit of heavy metals in spicy but other metal concentrations was within tolerable limit. The current research’s findings will convey a strong message for the government body, policy maker to establish rules and regulation in order to protect food chain contamination, environment pollution and will be helpful for public awareness. An immediate attention from the concerned authorities is required in order to protect food chain contamination and environment pollution.