Fatma Bahar Cebesoy

Homocysteine, folic acid and vitamin B12 levels in maternal and umbilical cord plasma and homocysteine levels in placenta in pregnant women with pre‐eclampsia

Aim:  The aim of this study was to evaluate maternal and fetal serum levels of homocysteine, folic acid, vitamin B12 and placental tissue levels of homocysteine and their association with severity of pre‐eclampsia.

CA-125 and CRP are Elevated in Preeclampsia

Objective: To determine the relationship between the cancer antigen-125 (CA-125) and C-reactive protein (CRP) with preeclampsia and eclampsia. Methods: The study group included 54 preeclamptic/eclamptic women, and 56 healthy pregnant women served as the control group. Mean arterial pressure (MAP) and albumin levels were used to monitor the severity of disease. CRP and CA-125 levels were determined. The cut-offs for CRP and CA-125 were 5 mg/L and 35 IU/ml. The t-test, Pearson correlation and ANOVA were used for statistical analysis. Values of p < 0.05 were considered to be significant. Results: CRP and CA-125 parameters were significantly higher in the study group (p < 0.001), and were significantly higher in severe preeclampsia and eclampsia groups than in mild preeclampsia (p < 0.001). Significant correlations were found between CRP/MAP, CRP/albumin, CA-125/MAP and CA-125/albumin (p < 0.001). Conclusion: CRP and CA-125 are elevating markers in preeclampsia.

Bilateral femur fracture in a newborn: an extreme complication of cesarean delivery

AbstractIntroductionBilateral femoral fracture due to birth trauma which is extremely rare, can occur during cesarean section.Material and methodsThis case represents a newborn delivered by cesarean section for breech presentation who sustained bilateral subtrochanteric fracture of the femur.ResultThe newborn was treated with immobilization in pelvipedal cast.ConclusionIt has been concluded that performing accurate delivery technique and immediate evaluation–orthopedic consultation of the newborn in the presence of forced obstetrical maneuver are important.

Dicephalic parapagus conjoined twins: A rare second trimester sonographic diagnosis

Conjoined twins are 1 of the rarest and most challenging congenital malformations. It occurs if twinning is initiated after the embryonic disc and rudimentary amniotic sac have been formed. We report a very rare case of dicephalic parapagus that was diagnosed by transabdominal sonography.

A rare mass formation of the vulva: giant cavernous hemangioma.

Objective. Vulvar hemangioma is an extremely rare pathology in adult women causing sexual dysfunction, pain, and cosmetic problems requiring therapeutic intervention. Materials and Methods. We present a case of an isolated giant vulvar cavernous hemangioma with a 2-year history that macroscopically seemed to be a vulvar varicosis but was actually detected at the end to be cavernous hemangioma in an adult patient with no history of other disease. Results. The patient was treated with surgical excision because of progressive complaints. Histopathologic evaluation suggested cavernous hemangioma. Conclusion. Hemangiomas can undergo spontaneous involution; thus, treatment may be reserved for those lesions of functional or psychological concern. In this case, surgical correction was used both as a diagnostic method and as a therapeutic intervention because of progressive complaints such as pain, feeling of pressure, and sexual dysfunction.

Fibrinolytic Therapy of Prosthetic Mitral Valve Thrombosis During Pregnancy: Three Case Reports and Review of the Literature

The incidence of prosthetic valve thrombosis (PVT), which is a life-threatening complication, increased during pregnancy because of the hypercoagulable state. Despite adequate anticoagulation, the incidence of PVT has been estimated as 4% to 14% during pregnancy. Prosthetic valve thrombosis occurring during pregnancy requires urgent therapy including fibrinolytic therapy, valve replacement, and surgical thrombectomy due to high mortality. Although surgery has traditionally been the standard procedure for treatment of PVT, fibrinolytic therapy may be used as first-line therapy according to data from the recent reports. Data about the fibrinolytic therapy is scarce and controversial in the setting of pregnancies complicated with PVT. Herein, we share the outcomes of 3 pregnant women complicated with PVT and treated with recombinant tissue-type plasminogen activator.

A case of Salmonella typhi endocarditis in pregnancy.

Infective endocarditis (IE) is an uncommon but life-threatening infection during pregnancy. Although there have been several reports of endocarditis caused by Salmonella typhi, to our knowledge it has not been reported as a cause of endocarditis during pregnancy. We report a case of 27-year-old pregnant woman with aortic valve IE caused by S. typhi, who had moderate mitral stenosis and aortic regurgitation. During pregnancy, fever, increase in sedimentation should always alert the physician about the possibility of IE, especially in the presence of predisposing clinical conditions. Whenever possible, transesophageal echocardiographic evaluation should be performed because transthoracic echocardiography might not always demonstrate vegetation as in the present case.

An extraordinary cause of vertebral fracture in pregnant woman: brucellosis.

Herein, we report the unique case of Brucella-related lumbar vertebral fracture in a first trimester pregnant woman. The unique effective treatment protocol for the infection is prolonged combined antibiotics and immobilization with follow-up, even in the presence of vertebral fracture related to spinal disease. With the accurate choice of anthiobitics (suitable, non-teratogenic and non-toxic for the fetus) therapeutic abortion is not indicated.

A False Negative QF-PCR and Trisomy 18-Trisomy 9 Mosaicism: A case Report

SUMMARY Using QF-PCR for rapid prenatal diagnosis of major chromosome aneuploidies demonstrated that the method is highly efficient, reliable and cost effective in the literature. A discrepancy has been showed between QF-PCR and karyotyping results as 0.2% in mosaicism.Our case was in 17 th gestational week who referred to our clinic for having a trisomy 18 risk as 1 in 50 in triple test.On the ultrasonography, we detected bilateral choroid plexus cysts and bilateral pyelectasia.After amniocentesis QF-PCR has been showed a normal chromosomal patern and cytogenetic analysis has been showed trisomy 18 and trisomy 9 mosaicism.

Ultrafast magnetic resonance imaging of omphalopagus conjoined twins

Conjoined twins are extremely rare congenital malformations. Omphalopagus twins are the second most common variety of conjoined twins and usually are joined at the umbilicus. Herein, we present ultrafast magnetic resonance imaging (MRI) feature of this rare anomaly at 24 weeks of gestation. Ultrafast MRI can provide additional information that may help ultrasonography for antenatal characterization of such anomalies.