Ozcan Balat

Plasma lipid and lipoprotein concentrations in pregnancy induced hypertension.

OBJECTIVES Aim of this study was to evaluate implication of pregnancy induced hypertension on maternal plasma lipid, lipoprotein, apolipoprotein concentrations and lipid peroxidation products by a comparison of normal pregnancy vs. preeclampsia. DESIGN AND METHODS Thirty-four women with preeclampsia and 32 healthy pregnant women (controls) in the third trimester were recruited for this study. RESULTS In the preeclamptic group plasma total triglyceride, low density lipoprotein cholesterol (LDL-C), malondialdehyde (MDA) and apolipoprotein B (apo-B) were significantly increased, while plasma high density lipoprotein cholesterol (HDL-C) was significantly decreased compared to that of control group. There was no significant difference in total cholesterol and apolipoprotein A1 (apo-A1) concentrations. CONCLUSION Our findings suggest that preeclampsia share some metabolic characteristics with coronary artery disease such as dislipidemia and increased lipid peroxidation. However lipoprotein concentrations may be better biochemical markers of dislipidemia in the preeclamptic state than the corresponding apolipoproteins.

Homocysteine, folic acid and vitamin B12 levels in maternal and umbilical cord plasma and homocysteine levels in placenta in pregnant women with pre‐eclampsia

Aim:  The aim of this study was to evaluate maternal and fetal serum levels of homocysteine, folic acid, vitamin B12 and placental tissue levels of homocysteine and their association with severity of pre‐eclampsia.

Effect of fasting during Ramadan on fetal development and maternal health

Aim:  The aim of the present study was to determine whether fasting during Ramadan causes ketonemia and/or ketonuria and their effects on fetal intrauterine development.

CA-125 and CRP are Elevated in Preeclampsia

Objective: To determine the relationship between the cancer antigen-125 (CA-125) and C-reactive protein (CRP) with preeclampsia and eclampsia. Methods: The study group included 54 preeclamptic/eclamptic women, and 56 healthy pregnant women served as the control group. Mean arterial pressure (MAP) and albumin levels were used to monitor the severity of disease. CRP and CA-125 levels were determined. The cut-offs for CRP and CA-125 were 5 mg/L and 35 IU/ml. The t-test, Pearson correlation and ANOVA were used for statistical analysis. Values of p < 0.05 were considered to be significant. Results: CRP and CA-125 parameters were significantly higher in the study group (p < 0.001), and were significantly higher in severe preeclampsia and eclampsia groups than in mild preeclampsia (p < 0.001). Significant correlations were found between CRP/MAP, CRP/albumin, CA-125/MAP and CA-125/albumin (p < 0.001). Conclusion: CRP and CA-125 are elevating markers in preeclampsia.

The Changes of Plasma Malondialdehyde, Nitric Oxide, and Adrenomedullin Levels in Patients with Preeclampsia

Objective. The aim of the study was to investigate the role of malondialdehyde, nitric oxide and adrenomedullin in the etiopathogenesis of preeclampsia. Material and Methods. Forty-two pregnant women with preeclampsia and 30 healthy pregnant women were involved. The plasma concentrations of malondialdehyde, nitric oxide, and adrenomedullin were compared between the study group and the control group. Results. In women with preeclampsia the plasma concentrations of malondialdehyde was higher while nitric oxide and adrenomedullin concentrations were lower compared to control subjects. Conclusion. We concluded that the plasma levels of ADM and NO are decreased while MDA levels are increased in subjects with preeclampsia and that might contribute to the pathophysiology of preeclampsia through the lack of a paracrine vasodilatory effect on uteroplacental blood flow.

Primary pure ovarian choriocarcinoma mimicking ectopic pregnancy: a report of fulminant progression.

Nongestational choriocarcinoma of the ovary is a germ cell tumor with a worse prognosis than gestational choriocarcinoma. In this report we present a nongestational choriocarcinoma that was referred to our hospital as an ectopic pregnancy. The clinical features, management, and outcome are discussed.

Malondialdehyde, nitric oxide and adrenomedullin levels in patients with primary dysmenorrhea

Aim:  The aim of the study was to examine whether there was a relationship between primary dysmenorrhea and serum levels of malondialdehyde (MDA), nitric oxide (NO) and adrenomedullin (AM) in young women.

Effect of Ramadan fasting on maternal oxidative stress during the second trimester: A preliminary study

Aim:  To evaluate whether fasting during Ramadan has any significant effects on maternal oxidative stress or fetal health in healthy, pregnant women with an uncomplicated, second‐trimester, singleton pregnancy.

Measurement of the placental total antioxidant status in preeclamptic women using a novel automated method

Aim:  We aimed to measure the levels of total antioxidant status (TAS) in placental samples from preeclamptic pregnant women and evaluate the relation of placental TAS, total oxidant status (TOS) and oxidative stress index (OSI) with fetomaternal compartments using the more recently designated Erel method.

The relation between genitourinary prolapse and joint hypermobility in Turkish women

ObjectiveIn this cross-sectional study, we compared frequency of hypermobility syndrome in pelvic organ prolapse (POP) patients and normal healthy Turkish women.MethodsSixty-five women who had diagnosed as POP and ward to surgery and 52 healthy women with similar age group were included into this study.ResultsIt was found that subjects with POP had a significantly higher prevalence of joint hypermobility (53.8%) when compared with normal individuals (9.6%). No significant correlation was demonstrated between Beighton scores and incontinence, exercises pattern and hormone replacement therapy.ConclusionWe concluded that joint laxity is associated with POP but not with urinary incontinence in Turkish women.