Fazli Sozmen

Synthesis of Symmetrical Multichromophoric Bodipy Dyes and Their Facile Transformation into Energy Transfer Cassettes

Multichromophoric boron-dipyrromethene (Bodipy) dyes synthesized on phenylene-ethynylene platforms have been be converted to energy transfer cassettes in a one-step chemical transformation. Excitation energy transfer processes in these highly symmetrical derivatives were studied in detail, including time-resolved fluorescence spectroscopy techniques. Excitation spectra and the emission lifetimes suggest efficient energy transfer between the donor and acceptor chromophore. These novel energy transfer cassettes, while highlighting a short-cut approach to similar energy transfer systems, could be useful as large pseudo-Stokes shift multichromophoric dyes with potential applications in diverse applications.

Heteroleptic Metallosupramolecular Complexes of Bodipy Dyes as Energy Transfer Cassettes

Bodipy dyes with integral phenanthroline and terpyridine units heteroleptically assemble in the presence of zinc(II) ions to form energy transfer cassettes. These discrete complexes exhibit an approach to modularly designed efficient energy transfer and light harvesting systems through metal ion coordination.

Extraction of the Essential Oil from Endemic Origanum bilgeri P.H.Davis with Two Different Methods: Comparison of the Oil Composition and Antibacterial Activity

The antibacterial activity and chemical composition of the essential oils (EOs) isolated from Origanum bilgeri P.H.Davis by two different extraction methods, i.e., hydrodistillation (HD) and solvent‐free microwave extraction (SFME), were examined. This endemic Origanum species had shown very good antibacterial activity. The composition of the O. bilgeri EOs obtained by SFME and HD was investigated by GC/MS analysis. The main components of the oils obtained by both methods were carvacrol (90.20–84.30%), p‐cymene (3.40–5.85%), γ‐terpinene (0.47–1.20%), and thymol (0.69–1.08%). The EO isolation by SFME offered many important advantages, including a higher extraction yield, a shorter extraction time, and a higher content of the active component carvacrol. The carvacrol‐rich oils obtained by both HD and SFME showed a good antibacterial activity. The largest inhibition zones were observed for the O. bilgeri EO obtained by SFME. Our study suggests that O. bilgeri EO has the potential to be used as preventative against bacterial contamination in many foods, instead of the common synthetic antimicrobial products.

Solvent-free microwave extraction and hydrodistillation of essential oils from endemic Origanum husnucanbaseri H. Duman, Aytaç & A. Duran: comparison of antibacterial activity and contents

The essential oils (EOs) obtained by solvent-free microwave extraction (SFME) and hydrodistillation (HD) from endemic Origanum husnucanbaseri H. Duman, Aytaç & A. Duran were investigated using the gas chromatography–mass spectrometry system. The main constituents of both oils obtained from SFME and HD from O. husnucanbaseri are borneol (15.2–12.8%), α-terpineol (12.3–10.8%) and trans-sabinene hydrate (11.8–9.92%). The EO obtained from SFME contained substantially higher amounts of oxygenated compounds and lower amounts of monoterpenes than that from HD. The antibacterial activities of the EOs from SFME and HD were evaluated by the disc diffusion method against six bacterial strains. The EO extracted by SFME was more effective than the EO extracted by HD against the tested bacteria, except for Klebsiella pneumoniae American type culture collection (ATCC) 13883. Streptococcus pyogenes ATCC 19615 and Staphylococcus aureus ATCC 25923 in particular were more sensitive against the EO extracted by SFME.

Designing BODIPY-based probes for fluorescence imaging of β-amyloid plaques

Styryl-congutated BODIPY dyes which are structurally similar to known Aβ peptide binding dyes, were designed and synthesized. The binding is accompanied by a large increase in the emission intensity in all cases, suggesting a high potential for use in the fluorescence imaging of Aβ plaques.