Filipe Carreira da Silva

No Deep Pockets: Some Stylized Empirical Results on Firms’ Financial Constraints

This paper is a survey of recent empirical work on financial constraints faced by firms. It is organized as a series of stylized results which mirror what is generally understood about the severity of financial constraints and the effects that they have upon firms. The review of the literature shows that (a) financial constraints are a widespread key concern for firms, hindering their ability to carry out their optimal investment and growth trajectories and (b) the severity of such constraints depends on institutional and firm specific characteristics, as well as on the nature of investment projects.

Genetic basis of Alzheimer's dementia: role of mtDNA mutations

Alzheimers disease (AD) is the most common neurodegenerative disorder associated to dementia in late adulthood. Amyloid precursor protein, presenilin 1 and presenilin 2 genes have been identified as causative genes for familial AD, whereas apolipoprotein E ɛ4 allele has been associated to the risk for late onset AD. However, mutations on these genes do not explain the majority of cases. Mitochondrial respiratory chain (MRC) impairment has been detected in brain, muscle, fibroblasts and platelets of Alzheimers patients, indicating a possible involvement of mitochondrial DNA (mtDNA) in the aetiology of the disease. Several reports have identified mtDNA mutations in Alzheimers patients, suggesting the existence of related causal factors probably of mtDNA origin, thus pointing to the involvement of mtDNA in the risk contributing to dementia, but there is no consensual opinion in finding the cause for impairment. However, mtDNA mutations might modify age of onset, contributing to the neurodegenerative process, probably due to an impairment of MRC and/or translation mechanisms.

Do financial constraints threat the innovation process? Evidence from Portuguese firms

This paper broadly addresses the financing problems of the innovation process, by analysing the extent to which financial constraints hinder firms’ investment in R&D and innovation, as well as investigating the role of public financial support in alleviating such constraints. In order to overcome the problems associated with measuring financial constraints, we make use of both indirect and direct measures of constraints. Our findings suggest that while financial constraints have a perverse effect upon R&D investment and innovation, there is no evidence that subsidies mitigate such constraints. Accordingly, we raise a number of questions regarding the efficiency and effectiveness of subsidies in alleviating firms’ financial constraints.

Frontotemporal dementia and mitochondrial DNA transitions

Frontotemporal dementia (FTD) is the second most common type of primary degenerative dementia. Some patients present an overlap between Alzheimers disease (AD) and FTD both in neuropathological and clinical aspects. This may suggest a similar overlap in physiopathology, namely an involvement of mitochondrial DNA (mtDNA) in FTD, as it has been associated to AD. To determine if mtDNA is involved in FTD, we performed a Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) analysis, specific to mtDNA NADH Dehydrogenase subunit 1 (ND1) nucleotides 3337-3340, searching for mutations previously described in Parkinsons and AD patients. We could identify one FTD patient with two mtDNA transitions: one already known (3316 G-to-A) and another unreported (3337 G-to-A). Additionally, mitochondrial respiratory chain complex I activity was reduced in leukocytes of this patient (36% of the control mean activity). To our knowledge, this is the first report of mtDNA variants in FTD patients.

Books and canon building in sociology: The case of Mind, Self, and Society

This paper discusses the canonization process of George Herbert Mead (1863–1931) in sociology through a recounting of the history of the book Mind, Self, and Society (1934). The relation between Mead and this particular work has no parallel in the history of sociological theory. Although the book was not written by Mead, or even organized under his direction, it has been through it that generations of academics and students have come in contact with Mead’s ideas. There are two main goals behind this exercise in historical reconstruction. First, the study of how Mind, Self, and Society came into existence and acquired classical standing offers an insightful view of the contingency and the complexity of canon formation. It is on this continuous process of reception, through which certain texts and authors acquire classical value, which the second part of the article focuses. It discusses the extent to which the history of the reception of Mead’s ideas would have been very different, and the impact of his ideas for theory building substantially larger, if it had been based, not on a posthumously published transcript, but on his own work.

Democracia deliberativa hoje: desafios e perspectivas

Este e a versao final do artigo. Apareceu pela primeira vez pela Universidade de Brasilia Instituto de Ciencia Politica via http://dx.doi.org/10.1590/S0103-33522013000100005

Cultural Adaptation of the Portuguese Version of the "Sniffin' Sticks" Smell Test: Reliability, Validity, and Normative Data.

The cross-cultural adaptation and validation of the Sniffin`Sticks test for the Portuguese population is described. Over 270 people participated in four experiments. In Experiment 1, 67 participants rated the familiarity of presented odors and seven descriptors of the original test were adapted to a Portuguese context. In Experiment 2, the Portuguese version of Sniffin`Sticks test was administered to 203 healthy participants. Older age, male gender and active smoking status were confirmed as confounding factors. The third experiment showed the validity of the Portuguese version of Sniffin`Sticks test in discriminating healthy controls from patients with olfactory dysfunction. In Experiment 4, the test-retest reliability for both the composite score (r71 = 0.86) and the identification test (r71 = 0.62) was established (p<0.001). Normative data for the Portuguese version of Sniffin`Sticks test is provided, showing good validity and reliability and effectively distinguishing patients from healthy controls with high sensitivity and specificity. The Portuguese version of Sniffin`Sticks test identification test is a clinically suitable screening tool in routine outpatient Portuguese settings.

Outline of a Social Theory of Rights: A Neo-Pragmatist Approach

This article articulates a neo-pragmatist theory of human rights by drawing and expanding upon the American classical pragmatism of G.H. Mead. It characterizes this neo-pragmatist theory of rights by its anti-foundationalist, relational, fictive, and constitutive nature, and begins by providing a reconstruction of Mead’s social pragmatist approach to rights, a contribution systematically ignored by contemporary sociologists of rights. Next, it details the cost of this disciplinary oblivion by examining how much neo-pragmatism, critical theory, and legal consciousness studies have meanwhile gained by engaging with Mead’s work on rights. Finally, it discusses the contributions of this historical-theoretical exercise to the rapidly growing sociology of rights, and shows that by supplementing the neo-Meadian approach with a recent interpretation of Hobbes’s fictional theory of politics, there appear to be substantive gains in the empirical study of the origins, consequences, meaning, and denial of rights.

G. H. Mead: a system in a state of flux

This article offers an original, intellectual portrait of G. H. Mead. My reassessment of Mead’s thinking is founded, in methodological terms, upon a historically minded yet theoretically oriented strategy. Mead’s system of thought is submitted to a historical reconstruction in order to grasp the evolution of his ideas over time, and to a thematic reconstruction organized around three major research areas or pillars: science, social psychology and politics. If one re-examines the entirety of Mead’s published and unpublished writings from the point of view of contemporary social and political theory, one can see that his contributions transcend the field of social psychology. Mead’s innovative insights on the communicative aspects of social life and individual conscience are yet to be fully explored by current social and political theorists. This is partly due to the fact that his was a system in a state of flux, ever escaping the final written form.This article offers an original, intellectual portrait of G. H. Mead. My reassessment of Mead’s thinking is founded, in methodological terms, upon a historically minded yet theoretically oriented strategy. Mead’s system of thought is submitted to a historical reconstruction in order to grasp the evolution of his ideas over time, and to a thematic reconstruction organized around three major research areas or pillars: science, social psychology and politics. If one re-examines the entirety of Mead’s published and unpublished writings from the point of view of contemporary social and political theory, one can see that his contributions transcend the field of social psychology. Mead’s innovative insights on the communicative aspects of social life and individual conscience are yet to be fully explored by current social and political theorists. This is partly due to the fact that his was a system in a state of flux, ever escaping the final written form.

Mitochondrial DNA Variants in a Portuguese Population of Patients with Alzheimer’s Disease

Alzheimer’s disease (AD) is the most common neurodegenerative disorder associated with dementia in late adulthood. Mitochondrial respiratory chain impairment has been detected in the brain, muscle, fibroblasts and platelets of AD patients, indicating a possible involvement of mitochondrial DNA (mtDNA) in the etiology of the disease. Several reports have identified mtDNA mutations in AD patients, but there is no consensual opinion regarding the cause of the impairment. We have studied mtDNA NADH dehydrogenase subunit 1 nucleotides 3337–3340, searching for mutations. Our study group included 129 AD patients and 125 healthy age-matched controls. We have found alterations in two AD patients: one had two already known mtDNA modifications (3197 T-C and 3338 T-C) and the other a novel transition (3199 T-C) which, to our knowledge, has not been described before.