Francis Penin

Blood activity of Cu/Zn superoxide dismutase, glutathione peroxidase and catalase in Alzheimer's disease : a case-control study

Cu/Zn superoxide dismutase (Cu/Zn SOD), glutathione peroxidase (GPx) and catalase, which are the three main enzymes involved in cellular protection against damage due to oxygen-derived free radicals have been assayed in plasma and erythrocytes obtained from subjects with dementia of the Alzheimer type (DAT) and from controls. Blood samples were obtained from 25 patients with DAT and from age-matched subjects without diagnoses of neurological disease (non-DAT), as well as from younger individuals (reference group). Using appropriate statistical procedures, the three enzyme activities measured in blood of the elderly were decreased if compared to the younger reference group. Moreover, a significant increase in erythrocyte Cu/Zn SOD and catalase activities of DAT patients was observed compared to the non-DAT group. These results are discussed taking the free radical theory of aging into consideration.

Modalités du dépistage des dyshormonémies thyroïdiennes chez le sujet âgé hospitalisé

In a continuous series of 3836 patients over 60 years old, 24.1 % have abnormal tests, 1.28% present hyperthyroidism and 1.98% hypothyroidism. Screening with TSH alone and T4 if abnormality, appears as the most helpful and costless method in order to detect thyroid dysfunction in hospitalised elderly patients.

Encéphalite herpétique du sujet âgé: 13 observations

Herpes simplex encephalitis can rarely occured in the elderly. Clinical and paraclinical manifestations are the same as in young people. Prognosis depends on early diagnosis and treatment with aciclovir. Geriatric cases due to reinfection or endogen virus reactivation than to primo-infection.

Statut nutritionnel et en oligo-éléments dans les cardiomyopathies du sujet âgé

Nutritionnal status remain poor in hospitalized elderly for cardiopathy compared to healthy controls, secondary to bad general status. Selenium rate appears significantly lower in ischemic cardiomyopathy than in valvular or hypertension cardiopathy.

Dyshormonémies et dysthyroïdies du sujet âgé. A propos d'une série continue de 3836 patients

In a continous serie of 3836 patients over 60 years old, 73.9 % have normal thyroid test, 1.2 % present patent hyperthyroidism and 1.6 % hypothyroidism. Clinical and biological presentation are often not specific, because of polypathology frequently observed in the elderly.

Aspects gériatriques des colites à Clostridium difficile. À propos d'une série de 19 observations

The authors report 19 cases of colitis remains to Clostridium difficile in the elderly. Betalactam antibiotics and anti-diarrheic drugs use associated with lower immune response due to nutrionnal deficiency seems to be the main risk factors.

Tomographie cérébrale d'émission monophotonique (HmPAO-Tc 99 m SPECT) et encéphalite herpétique. Comparaison aux données du scanner et de I'IRM

SPECT scan in herpes simplex encephalitis shows initially temporal hyperperfusion and later iso then hypoperfusion. Hyperperfusion occurs before CT-scan hypodensity and hypoperfusion appears after CTsan and MRI definitive datas.

Hydrocéphalie secondaire à un mégadolichotronc basilaire. À propos de 2 observations

The authors reports two cases of anevrysmal malformation of the vertebral basilar arteries causing hydrocephalus. Others clinical aspects of intracranial diffuse arterectasis are cranial nerve palsies, ischemic of hemorrhagic complications.

Diabète insipide révélateur de métastase hypophysaire d'un néoplasme bronchique. A propos de deux observations

Abstract The authors report two cases of diabetes insipidus due to pituitary metastasis of lung neoplasm. The endocrine clinical manifestations of pituitary metastasis are rare, and usually the fact of involvement of the posterior pituitary.

Colite à cytomégalovirus chez des patients non immunodéprimés. À propos de deux observations

Abstract The authors report two cases of colitis remain to cytomegalovirus infection. No immunodepression etiology was found, exepting the age in one case.