Francis Tsow

A Hybrid Nanosensor for TNT Vapor Detection

Real-time detection of trace chemicals, such as explosives, in a complex environment containing various interferents has been a difficult challenge. We describe here a hybrid nanosensor based on the electrochemical reduction of TNT and the interaction of the reduction products with conducting polymer nanojunctions in an ionic liquid. The sensor simultaneously measures the electrochemical current from the reduction of TNT and the conductance change of the polymer nanojunction caused from the reduction product. The hybrid detection mechanism, together with the unique selective preconcentration capability of the ionic liquid, provides a selective, fast, and sensitive detection of TNT. The sensor, in its current form, is capable of detecting parts-per-trillion level TNT in the presence of various interferents within a few minutes.

A Hybrid Electrochemical−Colorimetric Sensing Platform for Detection of Explosives

A highly selective, sensitive, and low-cost hybrid sensing platform is developed based on extraordinary properties of explosives in an ionic liquid and an integrated electrochemical and colorimetric approach.

A Wearable and Wireless Sensor System for Real-Time Monitoring of Toxic Environmental Volatile Organic Compounds

An integrated volatile organic toxicants sensor with a Bluetooth device interface has been developed. The device is based on novel tuning fork sensor platform along with a wireless communication/interface technology taken in an integrated system approach. It features high sensitivity and selectivity. The sensitivity and selectivity are accomplished through the use of novel tuning fork sensor modified by design (molecularly imprinted) polymers and selective filtering. Experiments have shown that the device can detect toxic volatile organic compounds (VOCs) under high concentrations of common interferents from flavors and fragrances. Applications of the device for detection of BTEX in real-world situations such as outdoor and gas station VOCs have also been demonstrated. All these features make the device a promising candidate to be deployed in real-world applications, particularly in environmental health and air pollution studies.

Noncontact Monitoring Breathing Pattern, Exhalation Flow Rate and Pulse Transit Time

We present optical imaging-based methods to measure vital physiological signals, including breathing frequency (BF), exhalation flow rate, heart rate (HR), and pulse transit time (PTT). The breathing pattern tracking was based on the detection of body movement associated with breathing using a differential signal processing approach. A motion-tracking algorithm was implemented to correct random body movements that were unrelated to breathing. The heartbeat pattern was obtained from the color change in selected region of interest (ROI) near the subjects mouth, and the PTT was determined by analyzing pulse patterns at different body parts of the subject. The measured BF, exhaled volume flow rate and HR are consistent with those measured simultaneously with reference technologies (r = 0.98, p <; 0.001 for HR; r = 0.93, p <; 0.001 for breathing rate), and the measured PTT difference (30-40 ms between mouth and palm) is comparable to the results obtained with other techniques in the literature. The imaging-based methods are suitable for tracking vital physiological parameters under free-living condition and this is the first demonstration of using noncontact method to obtain PTT difference and exhalation flow rate.

A Wireless Hybrid Chemical Sensor for Detection of Environmental Volatile Organic Compounds

A hybrid sensor for monitoring volatile organic compounds in air is developed. The device combines two orthogonal sensing principles, selective molecular binding with a microfabricated quartz tuning fork detector and separation of analytes with a column. The tuning fork detector is functionalized with molecular imprinted polymers for selective binding to benzene, toluene, ethylbenzene, and xylenes (BTEX), and the separation column provides further discrimination of the analytes for real world complex sample analysis. The device is wireless, portable, battery-powered, and cell-phone operated, and it allows reliable detection in parts per billion by volume-levels of BTEX in the presence of complex interferents. The hybrid device is suitable for occupational, environmental health, and epidemiological applications.

Hybrid mechanoresponsive polymer wires under force activation.

Force activation is triggered in a stretched polymer wire with color changes produced as a consequence of the molecules undergoing structural and conformational changes. A markedly increased efficiency of force activation is achieved by decreasing the diameter of the wires. The hybrid mechanosensitive polymer wire can function as micro- and nanoscale force sensor.

Hybrid Separation and Detection Device for Analysis of Benzene, Toluene, Ethylbenzene, and Xylenes in Complex Samples

We present a hybrid system for rapid detection and analysis of benzene, toluene, ethylbenzene, and xylenes (BTEX). The system combines selective and sensitive sensing elements with a fast and miniaturized chromatographic separation method. The sensing elements are an array of microfabricated quartz crystal tuning forks modified with selective molecularly imprinted polymers, and the separation method uses optimized short columns. The high sensitivity and selectivity of the sensing elements together with the help of the separation provides fast detection and analysis of BTEX in real samples containing highly concentrated interfering agents without preconcentration or heating of columns. The low cost, low power consumption, and small size of the hybrid device are particularly suitable for occupational health, industrial safety, and epidemiological applications.

Novel monitor paradigm for real-time exposure assessment.

A wearable monitor that can reliably, accurately, and continuously measure personal exposure levels of various toxicants would not only accelerate the current environmental and occupational health and safety studies, but also enable new studies that are not possible with the current monitoring technology. Developing such a monitor has been a difficult challenge, and requires innovative sensing science and creative engineering. We have developed, built, and tested a wearable monitor for real-time detection of toxic hydrocarbons and acids in the environment. The monitor is low-cost, accurate, and user friendly. In addition, it can communicate wirelessly with a cell phone in which the monitoring results can be processed, displayed, stored, and transmitted to a designated computer. We have validated the functions and performance of the monitor, and carried out field tests with workers involving waste management, fire overhaul, and floor-cleaning activities, as well as with first- and second-hand smokers. The averaged exposure levels are in agreement with those determined by the standard NIOSH methods. The monitor provides accurate and real-time exposure assessment for the workers involving different activities. The real-time and continuous monitoring capability makes it possible to correlate the exposure levels with different activities and changes in the microenvironments. The monitor provides unprecedented real-time information that will help advance occupational safety and environmental health studies. It may also be used to better protect workers from occupational overexposure to toxic molecules.

Microfabricated tuning fork temperature and infrared sensor

The authors demonstrated a microfabricated tuning fork temperature/infrared sensor with noise equivalent temperature difference (NETD) of 0.5mK at 20°C and with a thermal limited noise level of 5μ°C. The sensor raw material can cost less than 10 cents each and has a time constant of approximately 50ms. The sensitivity of infrared signal can potentially be further improved and optimized by selecting polymer materials with a proper thermal response.

Noncontact Monitoring of Blood Oxygen Saturation Using Camera and Dual-Wavelength Imaging System

We present a noncontact method to monitor blood oxygen saturation (SpO2). The method uses a CMOS camera with a trigger control to allow recording of photoplethysmography (PPG) signals alternatively at two particular wavelengths, and determines the SpO2 from the measured ratios of the pulsatile to the nonpulsatile components of the PPG signals at these wavelengths. The signal-to-noise ratio (SNR) of the SpO2 value depends on the choice of the wavelengths. We found that the combination of orange (λ = 611 nm) and near infrared (λ = 880 nm) provides the best SNR for the noncontact video-based detection method. This combination is different from that used in traditional contact-based SpO2 measurement since the PPG signal strengths and camera quantum efficiencies at these wavelengths are more amenable to SpO2 measurement using a noncontact method. We also conducted a small pilot study to validate the noncontact method over an SpO2 range of 83%-98%. This study results are consistent with those measured using a reference contact SpO2 device (r = 0.936, p <; 0.001). The presented method is particularly suitable for tracking ones health and wellness at home under free-living conditions, and for those who cannot use traditional contact-based PPG devices.