Francisco J. Blanes-Mompó

Medium-term visual, refractive, and intraocular stability after implantation of a posterior chamber phakic intraocular lens to correct moderate to high myopia

PURPOSE: To evaluate the medium‐term refractive and visual outcomes and the complications after implantation of a silicone posterior chamber phakic intraocular lens (PC pIOL) for moderate to high myopia. SETTING: Oftalmar, Medimar International Hospital, Alicante, Spain. DESIGN: Retrospective case series. METHODS: Uncorrected (UDVA) and corrected (CDVA) distance visual acuities, refraction, and intraocular pressure were evaluated during a medium‐term follow‐up. Postoperative complications were also studied. RESULTS: The study enrolled 35 eyes (mean preoperative spherical equivalent [SE] −10.25 diopters [D] ± 3.19 [SD]) of 20 patients with a mean age of 31.83 ± 8.87 years and a mean follow‐up of 57.34 ± 9.24 months. The mean UDVA improved from 2.40 ± 0.20 logMAR preoperatively to 0.08 ± 0.13 logMAR at the last postoperative visit (P<.01). The mean CDVA improved from 0.11 ± 0.09 logMAR to 0.02 ± 0.09 logMAR, respectively (P<.01). The postoperative CDVA was 0.1 or better in 30 eyes (85.71%), with 22 eyes (62.86%) gaining lines of CDVA. The final efficacy index was 1.16 and the final safety index, 1.26. Regarding predictability, 34 eyes (97.14%) had an SE within ±1.00 D and 33 eyes (94.28%) within ±0.50 D. The complications were PC pIOL decentration (2 eyes, 5.71%), cortical lens opacification (1 eye, 2.86%), and retinal detachment (1 eye, 2.86%). CONCLUSIONS: Implantation of a PC pIOL to correct moderate to high myopia was efficient and predictable in the medium term, with intraocular stability in most cases. New designs and criteria for PC pIOL size selection should be developed. Financial Disclosure: No author has a financial or proprietary interest in any material or method mentioned.

New-generation hybrid contact lens for the management of extreme irregularity in a thin cornea after unsuccessful excimer laser refractive surgery.

Purpose: To report a very successful outcome obtained with the fitting of a new-generation hybrid contact lens of reverse geometry in a thin cornea with extreme irregularity due to the presence of a central island after unsuccessful myopic excimer laser refractive surgery. Methods: A 32-year-old man attended to our clinic complaining of very poor vision in his right eye after bilateral laser in situ keratomileusis (treatment or surgery) for myopia correction and some additional retreatments afterward. After a comprehensive ocular evaluation, contact lens fitting with a reverse geometry hybrid contact lens (SynergEyes PS, SynergEyes, Carlsbad, CA) was proposed as a solution for this case. Visual, refractive, and ocular aberrometric outcomes with the contact lens were evaluated. Results: Distance visual acuity improved from a prefitting uncorrected value of 20/200 to a postfitting corrected value of 20/16. Prefitting manifest refraction was +6.00 sphere and −3.00 cylinder at 70°, with a corrected distance visual acuity of 20/40. Higher order root mean square for a 5-mm pupil changed from a prefitting value of 1.45 to 0.34 µm with the contact lens. The contact lens wearing was reported as comfortable, and the patient was very satisfied with this solution. Conclusions: The SynergEyes PS contact lens seems to be an excellent option for the visual rehabilitation of corneas with extreme irregularity after myopic excimer laser surgery, minimizing the level of higher order aberrations and providing an excellent visual outcome.

Results of laser in situ keratomileusis performed using solid-state laser technology

PURPOSE: To evaluate and report the visual, refractive, and aberrometry outcomes of laser in situ keratomileusis (LASIK) to correct low to moderate myopia using a commercial solid‐state laser. SETTING: Oftalmar, Medimar International Hospital, Alicante, Spain. DESIGN: Prospective case series. METHODS: This study evaluated consecutive eyes with low to moderate myopia that had LASIK performed using a Pulzar Z1 solid‐state laser. Visual, refractive, and aberrometry changes as well as potential complications were evaluated. RESULTS: The study enrolled 60 eyes (34 patients). The mean follow‐up was 8.5 months (range 6 to 13 months). There was a significant improvement in logMAR uncorrected distance visual acuity (UDVA) postoperatively (P<.01). No significant change was detected in logMAR corrected distance visual acuity (CDVA) (P=.21). The postoperative logMAR UDVA was 0.1 (approximately 20/25) or better in 57 eyes (95.00%). The mean overall efficacy index was 0.99 and the mean safety index, 1.02. Postoperatively, 1 eye (1.67%) lost lines (1 line) of CDVA. The postoperative spherical equivalent was within ±0.50 diopter in 58 eyes (96.67%). There was a small, but statistically significant increase in the primary coma root mean square (0.17 μm) and in the magnitude of primary spherical aberration (0.09 μm). No severe complications occurred. CONCLUSION: Laser in situ keratomileusis using the solid‐state laser provided predictable correction of low to moderate myopia, minimizing the induction of higher‐order aberrations and preserving CDVA. Financial Disclosure: No author has a financial or proprietary interest in any material or method mentioned.

Fixed Mydriatic Pupil Associated with an Intraocular Pressure Rise as a Complication of the Implant of a Phakic Refractive Lens (PRL)

Abstract We describe a case report of a patient that was implanted with a posterior chamber phakic intraocular lens (Phakic Refractive Lens, PRL) for the correction of moderate myopia and who developed postoperatively a fixed mydriasis compatible with an Urrets-Zavalia Syndrome (UZS). Specifically, a sudden acute increase of IOP in the left eye was observed in the immediate postoperative period. After IOP stabilization, the refractive result was good, but a fixed and mydriatic pupil appeared. This condition led the patient to experience visual discomfort, halos, and glare associated with high levels of higher-order aberrations in spite of the good visual result. A tinted-contact lens was fitted in order to minimize those symptoms. The UZS should be considered as a possible complication after implantation of posterior chamber phakic intraocular lenses.

Influence of the difference between corneal and refractive astigmatism on LASIK outcomes using solid-state technology.

Purpose: To evaluate the influence of the difference between preoperative corneal and refractive astigmatism [ocular residual astigmatism (ORA)] on outcomes obtained after laser in situ keratomileusis (LASIK) surgery for correction of myopic astigmatism using the solid-state laser technology. Methods: One hundred one consecutive eyes with myopia or myopic astigmatism of 55 patients undergoing LASIK surgery using the Pulzar Z1 solid-state laser (CustomVis Laser Pty Ltd, currently CV Laser) were included. Visual and refractive changes at 6 months postoperatively and changes in ORA and anterior corneal astigmatism and posterior corneal astigmatism (PCA) were analyzed. Results: Postoperatively, uncorrected distance visual acuity improved significantly (P < 0.01). Likewise, refractive cylinder magnitude and spherical equivalent were reduced significantly (P < 0.01). In contrast, no significant changes were observed in ORA magnitude (P = 0.81) and anterior corneal astigmatism (P = 0.12). The mean overall efficacy and safety indices were 0.96 and 1.01, respectively. These indices were not correlated with preoperative ORA (r = −0.15, P = 0.15). Furthermore, a significant correlation was found between ORA (r = 0.81, P < 0.01) and PCA postoperatively, but not preoperatively (r = 0.12, P = 0.25). Likewise, a significant correlation of ORA with manifest refraction was only found postoperatively (r = −0.38, P < 0.01). Conclusions: The magnitude of ORA does not seem to be a predictive factor of efficacy and safety of myopic LASIK using a solid-state laser platform. The higher relevance of PCA after surgery in some cases may explain the presence of unexpected astigmatic residual refractive errors.

Clinical impact of a spontaneous decentration of a phakic refractive lens.

Purpose. To evaluate the clinical impact and possible causes of a spontaneous decentration of a phakic refractive lens (PRL) implanted in a highly myopic eye, and analyzing the visual, refractive, and aberrometric outcome as well as the possible causes for this phenomenon. Methods. The description of a case of bilateral high myopia corrected by implantation with the phakic intraocular lens (pIOL) PRL (Carl Zeiss Meditec, Germany) is presented and documented. Both eyes had similar anatomical configuration, and therefore, a pIOL (Model 101) with the same size was implanted without any associated intraoperative complication. Clinical outcomes were evaluated during a 3-month follow-up. Results. Implanted pIOLs were properly positioned in both eyes and provided an excellent visual outcome during the immediate postoperative period. However, 1 month after surgery, the patient presented a logarithm of the minimum angle of resolution uncorrected distance visual acuity of 0.15 and 0 in the OD and OS, respectively. Subjective refraction in the OD was +1.00 to 1.00 × 15°, with logarithm of the minimum angle of resolution corrected distance visual acuity of 0. Temporal displacement of the PRL was evident in the biomicroscopic examination and analyzed in detail with advanced imaging techniques finding an asymmetric vault. Regarding aberrometry, larger amounts of primary coma, and spherical aberration were present in the OS. Two months later, the situation remained stable. Conclusions. Spontaneous PRL decentration is not necessarily associated with a visual quality loss and a bad selection of pIOL size. For implantation of this pIOL, a comprehensive analysis of the zonule would be necessary.

Algorithm for Correcting the Keratometric Error in the Estimation of the Corneal Power in Keratoconus Eyes after Accelerated Corneal Collagen Crosslinking

Purpose To analyze the errors associated to corneal power calculation using the keratometric approach in keratoconus eyes after accelerated corneal collagen crosslinking (CXL) surgery and to obtain a model for the estimation of an adjusted corneal refractive index (nkadj) minimizing such errors. Methods Potential differences (ΔPc) among keratometric (Pk) and Gaussian corneal power (PcGauss) were simulated. Three algorithms based on the use of nkadj for the estimation of an adjusted keratometric corneal power (Pkadj) were developed. The agreement between Pk(1.3375) (keratometric power using the keratometric index of 1.3375), PcGauss, and Pkadj was evaluated. The validity of the algorithm developed was investigated in 21 keratoconus eyes undergoing accelerated CXL. Results P k(1.3375) overestimated corneal power between 0.3 and 3.2 D in theoretical simulations and between 0.8 and 2.9 D in the clinical study (ΔPc). Three linear equations were defined for nkadj to be used for different ranges of r1c. In the clinical study, differences between Pkadj and PcGauss did not exceed ±0.8 D nk = 1.3375. No statistically significant differences were found between Pkadj and PcGauss (p > 0.05) and Pk(1.3375) and Pkadj (p < 0.001). Conclusions The use of the keratometric approach in keratoconus eyes after accelerated CXL can lead to significant clinical errors. These errors can be minimized with an adjusted keratometric approach.

Usefulness of bandage contact lenses in the immediate postoperative period after uneventful myopic LASIK

PURPOSE To determine the usefulness of a silicone-hydrogel bandage contact lens (BCL) in the immediate postoperative period after uneventful myopic laser in-situ keratomileusis (LASIK). METHODS The study design was randomized but not masked and data collection was prospective. This study comprised 51 consecutive myopic eyes intervened by means of the LASIK technique to compensate their refractive error. Patients were randomly assigned to two different groups. The experimental group included 24 eyes of 12 patients that were fitted with a BCL immediately after the flap replacement. The control group included 27 eyes of 14 patients with no BCL. Patients were examined 24h after the surgery; the experimental group was analyzed immediately after the extraction of the BCL. Postoperative uncorrected distance visual acuity (UDVA) and postoperative topographic indexes were compared to baseline in both groups. RESULTS The experimental group achieved worse results in the majority of the studied variables. Postoperative UDVA was worse in experimental group (p<0.01). Likewise, corneal asphericity (Q) was significantly higher in experimental group (p=0.024). Topographic indexes showed higher asymmetry in the corneal maps pertaining to experimental group. Specifically, the index of surface variance (ISV) (p=0.017) and index of vertical asymmetry (IVA) (p=0.031) were higher in experimental group. Also, the postoperative central corneal thickness (CCT) resulted in higher values for eyes pertaining to experimental group. CONCLUSIONS The fitting of a silicone-hydrogel BCL after uneventful LASIK provokes morphological changes in the ocular structures that may lead to a worse UDVA secondary to a higher postoperative CCT and corneal edema.