Rafael J. Pérez-Cambrodí

Correlation of Visual Performance With Quality of Life and Intraocular Aberrometric Profile in Patients Implanted With Rotationally Asymmetric Multifocal IOLs

PURPOSE To examine the visual performance of a rotationally asymmetric multifocal intraocular lens (IOL) by correlating the defocus curve of the IOL-implanted eye with the intraocular aberrometric profile and impact on the quality of life. METHODS A prospective, consecutive, case series study including 26 eyes from 13 patients aged between 50 and 83 years (mean: 65.54±7.59 years) was conducted. All patients underwent bilateral cataract surgery with implantation of a rotationally asymmetric multifocal IOL (Lentis Mplus LS-312 MF30, Oculentis GmbH). Distance and near visual acuity outcomes, intraocular aberrations, defocus curve, and quality of life (assessed using the National Eye Institute Visual Functioning Questionnaire-25) were evaluated postoperatively (mean follow-up: 6.42±2.24 months). RESULTS A significant improvement in distance visual acuity was found postoperatively (P<.01). Mean postoperative logMAR distance-corrected near visual acuity was 0.19±0.12 (∼20/30). Corrected distance visual acuity and near visual acuity of 20/20 or better were achieved by 30.8% and 7.7% of eyes, respectively. Of all eyes, 96.2% had a postoperative addition between 0 and 1.00 diopter (D). The defocus curve showed two peaks of maximum visual acuity (0 and 3.00 D of defocus), with an acceptable range of intermediate vision. LogMAR visual acuity corresponding to near defocus was directly correlated with some higher order intraocular aberrations (r⩾0.44, P⩽.04). Some difficulties evaluated with the quality of life test correlated directly with near and intermediate visual acuity (r⩾0.50, P⩽.01). CONCLUSIONS The Lentis Mplus multifocal IOL provides good distance, intermediate, and near visual outcomes; however, the induced intraocular aberrometric profile may limit the potential visual benefit.

Visual performance with simultaneous vision multifocal contact lenses.

Purpose:  The aim was to assess visual performance after PureVision high addition multifocal contact lens (PM) fitting through contrast sensitivity measured under different illumination levels for both distance and near.

Optic neuritis in pediatric population: A review in current tendencies of diagnosis and management

Optic neuritis is an inflammation of the optic nerve and may be related to different systemic conditions. The clinical presentation of this pathology usually includes sudden loss of visual acuity (VA) which may be unilateral or bilateral, visual field restriction, pain with eye movements, dyschromatopsia, a relative afferent pupillary defect and optic disk swelling. Optic neuritis in children has specific clinical features and a better prognosis than in adulthood. Although usually appears an underlying viral disease, the main concern for practitioners is the relationship of optic neuritis with multiple sclerosis. In addition to the classical techniques as magnetic resonance imaging (MRI), current tendencies of diagnosis for eye practitioners include new imaging devices as optical coherence tomography (OCT), useful to show a thinning of the retinal fibers layer (RFL) after the inflammatory episode. Regarding the management of these patients, short-term intravenous steroid dosages seem to be the best option to treat acute attacks characterized by a very poor bilateral VA.

Optical quality of the diabetic eye: a review

Diabetes mellitus is a metabolic disorder characterized by the presence of chronic hyperglycaemia. Several structural, morphological, and physiological changes in each of ocular component have been described in detail during the past decades. Due to these abnormalities, the diabetic patient undergoes a degradation of the retinal image by an increase of higher ocular aberrations and ocular scattering coming from mainly tear film, cornea, and crystalline lens. This review aims to provide an overview of current knowledge about the effects of diabetes mellitus in these optical phenomena and its consequence on the visual quality of the diabetic patient.

The posterior chamber phakic refractive lens (PRL): a review

Implantation of phakic intraocular lenses (pIOLs) is a reversible refractive procedure, preserving the patient’s accommodative function with minimal induction of higher order aberrations compared with corneal photoablative procedures. Despite this, as an intraocular procedure, it has potential risks such as cataracts, chronic uveitis, pupil ovalization, corneal endothelial cell loss, pigmentary dispersion syndrome, pupillary block glaucoma, astigmatism, or endophthalmitis. Currently, only two models of posterior chamber pIOLs are commercially available, the implantable collammer lens (STAAR Surgical Co.) and the phakic refractive lens (PRL; Zeiss Meditec). The number of published reports on the latter is very low, and some concerns still remain about its long-term safety. The present article reviews the published literature on the outcomes after PRL implantation in order to provide a general overview and evaluate its real potential as a surgical refractive option.

Medium-term visual, refractive, and intraocular stability after implantation of a posterior chamber phakic intraocular lens to correct moderate to high myopia

PURPOSE: To evaluate the medium‐term refractive and visual outcomes and the complications after implantation of a silicone posterior chamber phakic intraocular lens (PC pIOL) for moderate to high myopia. SETTING: Oftalmar, Medimar International Hospital, Alicante, Spain. DESIGN: Retrospective case series. METHODS: Uncorrected (UDVA) and corrected (CDVA) distance visual acuities, refraction, and intraocular pressure were evaluated during a medium‐term follow‐up. Postoperative complications were also studied. RESULTS: The study enrolled 35 eyes (mean preoperative spherical equivalent [SE] −10.25 diopters [D] ± 3.19 [SD]) of 20 patients with a mean age of 31.83 ± 8.87 years and a mean follow‐up of 57.34 ± 9.24 months. The mean UDVA improved from 2.40 ± 0.20 logMAR preoperatively to 0.08 ± 0.13 logMAR at the last postoperative visit (P<.01). The mean CDVA improved from 0.11 ± 0.09 logMAR to 0.02 ± 0.09 logMAR, respectively (P<.01). The postoperative CDVA was 0.1 or better in 30 eyes (85.71%), with 22 eyes (62.86%) gaining lines of CDVA. The final efficacy index was 1.16 and the final safety index, 1.26. Regarding predictability, 34 eyes (97.14%) had an SE within ±1.00 D and 33 eyes (94.28%) within ±0.50 D. The complications were PC pIOL decentration (2 eyes, 5.71%), cortical lens opacification (1 eye, 2.86%), and retinal detachment (1 eye, 2.86%). CONCLUSIONS: Implantation of a PC pIOL to correct moderate to high myopia was efficient and predictable in the medium term, with intraocular stability in most cases. New designs and criteria for PC pIOL size selection should be developed. Financial Disclosure: No author has a financial or proprietary interest in any material or method mentioned.

Reliability and Intersession Agreement of Microperimetric and Fixation Measurements Obtained with a New Microperimeter in Normal Eyes

Abstract Purpose: To evaluate the reliability and intersession agreement of measurements of retinal sensitivity as well as of the fixation pattern obtained in healthy eyes with a microperimeter integrating the mechanism of the scanning laser ophthalmoscope (SLO) with the static perimetry. Methods: This study included a sample of 44 healthy eyes of 44 subjects of a mean age of 27.0 ± 8.5 years. In all cases, microperimetric exams with the MAIA system (Centervue, Padova, Italy) were performed in three different sessions to evaluate the intersession repeatability. The consistency of measurements was analyzed by using the Friedman test and by analyzing the correlation between consecutive measurements. Agreement between the first and third sessions was assessed by using the Passing–Bablok regression analysis. The following parameters were analyzed: average threshold (AT), macular integrity (MI) index, fixation indexes P1 and P2, bivariate contour ellipse area (BCEA), major and minor axes of the ellipse and high preferred retinal locus position (PRLh). Results: Not statistically significant differences were found in the evaluated parameters between the three sessions (p ≥ 0.193). The correlation between consecutive measurements was moderate to strong for all parameters evaluated (r ≥ 0.49, p < 0.01), except for the MI and the position of the PRLh (r ≤ 0.305, p ≥ 0.05). The Passing–Bablok regression analysis showed a good agreement between the first and third measurement for all parameters, except for the MI and the position of the PRLh. Conclusion: MAIA MP system is able to provide consistent measurements of AT and fixation in normal subjects. MI and the position of PRLh seem to be the least reliable parameters in this group of patients.

Estimation of the central corneal power in keratoconus: theoretical and clinical assessment of the error of the keratometric approach.

Purpose: The aim of this study was to analyze theoretically the errors in the central corneal power calculation in eyes with keratoconus when a keratometric index (nk) is used and to clinically confirm the errors induced by this approach. Methods: Differences (&Dgr;Pc) between central corneal power estimation with the classical nk (Pk) and with the Gaussian equation ( ) in eyes with keratoconus were simulated and evaluated theoretically, considering the potential range of variation of the central radius of curvature of the anterior (r1c) and posterior (r2c) corneal surfaces. Further, these differences were also studied in a clinical sample including 44 keratoconic eyes (27 patients, age range: 14–73 years). The clinical agreement between Pk and (true net power) obtained with a Scheimpflug photography–based topographer was evaluated in such eyes. Results: For nk = 1.3375, an overestimation was observed in most cases in the theoretical simulations, with &Dgr;Pc ranging from an underestimation of −0.1 diopters (D) (r1c = 7.9 mm and r2c = 8.2 mm) to an overestimation of 4.3 D (r1c = 4.7 mm and r2c = 3.1 mm). Clinically, Pk always overestimated the given by the topography system in a range between 0.5 and 2.5 D (P < 0.01). The mean clinical &Dgr;Pc was 1.48 D, with limits of agreement of 0.71 and 2.25 D. A very strong statistically significant correlation was found between &Dgr;Pc and r2c (r = −0.93, P < 0.01). Conclusions: The use of a single value for nk for the calculation of corneal power is imprecise in keratoconus and can lead to significant clinical errors.

Ocular residual astigmatism and topographic disparity vector indexes in normal healthy eyes.

PURPOSE To define a range of normality for the vectorial parameters Ocular Residual Astigmatism (ORA) and topography disparity (TD) and to evaluate their relationship with visual, refractive, anterior and posterior corneal curvature, pachymetric and corneal volume data in normal healthy eyes. METHODS This study comprised a total of 101 consecutive normal healthy eyes of 101 patients ranging in age from 15 to 64 years old. In all cases, a complete corneal analysis was performed using a Scheimpflug photography-based topography system (Pentacam system Oculus Optikgeräte GmbH). Anterior corneal topographic data were imported from the Pentacam system to the iASSORT software (ASSORT Pty. Ltd.), which allowed the calculation of the ocular residual astigmatism (ORA) and topography disparity (TD). Linear regression analysis was used for obtaining a linear expression relating ORA and posterior corneal astigmatism (PCA). RESULTS Mean magnitude of ORA was 0.79 D (SD: 0.43), with a normality range from 0 to 1.63D. 90 eyes (89.1%) showed against-the-rule ORA. A weak although statistically significant correlation was found between the magnitudes of posterior corneal astigmatism and ORA (r=0.34, p<0.01). Regression analysis showed the presence of a linear relationship between these two variables, although with a very limited predictability (R(2): 0.08). Mean magnitude of TD was 0.89D (SD: 0.50), with a normality range from 0 to 1.87D. CONCLUSION The magnitude of the vector parameters ORA and TD is lower than 1.9D in the healthy human eye.

Soft multifocal simultaneous image contact lenses: a review

Soft multifocal simultaneous image contact lenses have boomed in recent years due to the growing number of presbyopic patients demanding visual solutions, allowing them to maintain their current standard of living. The concept of ‘simultaneous image’ is based on blur interpretation and/or blur tolerance of superimposed multiple images on the retina formed by various powers of a contact lens. This is the basis for a specific type of multifocal contact lens developed for the compensation of presbyopia. Manufacturers have released a great variety of soft simultaneous image lens designs to meet different patient needs but their fitting is still unsatisfactory in some cases. Some presbyopes discontinue wearing contact lenses due to some limitations in visual quality and comfort that can be overcome with an appropriate contact lens selection based on a comprehensive pre‐fitting evaluation. This paper aims to review the different types of soft multifocal contact lenses that are currently available for presbyopic correction and to define the steps and factors crucial for their fitting, such as pupil, aberrations, accommodation and centring. A discussion about useful tools to achieve a customised fitting leading to a successful outcome, such as the defocus curve, power profile and questionnaires, is performed.