Frank J. Villani

Hydrolysis of polypeptide esters with tetrabutylammonium hydroxide

Abstract Tetrabutylammonium hydroxide is effective in hydrolysis of polypeptide esters to the corresponding acids with minimum racemization of the stereogenic centers at the α-positions. It is especially effective in hydrolysis of non-polar polypeptide esters that are insoluble in most common solvents.

Carbonyl hydration of oxymorphone and oxycodone hydrochloride

The minor component observed in aqueous proton (1H) and carbon (13C) NMR spectra of oxymorphone HCl and oxycodone HCl is produced by the reaction of these salts with water forming gem-diols and not due to the axial N-methyl isomer.