Luigi Anzalone

The chiral specific synthesis of DMP 754, a platelet GP IIbIIIa antagonist

Abstract An effective and chiral specific synthesis of DMP 754 ( 1 ), a non-peptide platelet GP IIb IIIa antagonist, is reported.

A practical synthesis of nonpeptide cyclic ureas as potent HIV protease inhibitors

Abstract The utilization of the oxydimethylene group to form a trioxepane ring for the protection of 1,2-diols was demonstrated. A process starting with natural L-tartaric acid as the chiral building block is utilized in the synthesis of optically active, nonpeptide cyclic ureas useful as HIV protease inhibitors.