Franz K. Bauer

Routine Clinical Use of Alemtuzumab in Patients With Heavily Pretreated B-Cell Chronic Lymphocytic Leukemia A Nation-Wide Retrospective Study in Austria

In previous studies, alemtuzumab demonstrated considerable activity in patients with previously treated B‐cell chronic lymphocytic leukemia (CLL), including fludarabine‐refractory disease. In this retrospective study, the authors evaluated the benefit of alemtuzumab monotherapy in unselected patients with advanced, previously treated CLL who received treatment in the routine clinical setting.

Thyroid gland weight determination from thyroid scintigrams with postmortem verification.

The determination of the weight of the human thyroid gland has become extremely important since the introduction of I131 in the treatment of hyperthyroidism. In most clinics estimates of the weight of the gland are obtained by palpation, which at best is a crude procedure. Allen and Goodwin (1) have recently described a more accurate method. The point-by-point technic of plotting the frontal area occupied by the thyroid gland used by Allen, Libby, and Cassen (2) has been simplified by the introduction of the “scintiscanner” (3, 4) for obtaining an actual size scintigram of the gland. The formula presented by Allen and Goodwin can be readily applied to measurements obtained from a scintigram. In the Wads-worth General Hospital (Los Angeles) this procedure has become routine in the determination of dosages of I131 for the treatment of hyperthyroidism and intractable heart disease (5). As the constant in the formula of Allen and Goodwin was obtained from a very limited series of autopsy and surgical material...

Accumulation of Homologous Radioiodinated Albumin in Experimental Tumors

Conclusion The data presented indicate that experimental tumors of the liver (Brown-Pearce) in rabbits accumulate more radio-iodinated rabbit albumin than normal liver tissue of the same animal. This increased concentration appears to be unrelated to vascularity since it was demonstrated in perfused animals.

Radioisotope Studies in Neuromuscular Disease: 2. Studies in Muscular Dystrophy and Myotonia Dystrophica with Sodium22 and Potassium42

PRELIMINARY isotope studies in various neuromuscular disease states have demonstrated a diminution of body potassium in patients with muscular dystrophy and myotonia dystr0phica.l The present investigation, a continuation of earlier studies, has been broadened to include the study of selected family members of muscular dystrophy patients. In addition, the body sodium content has been determined by isotope methods in order to better understand other aspects of electrolyte metabolism in primary muscle disease. The data have been obtained from a study of 33 patients with muscular dystrophy and myotonia dystrophica and 38 family members of patients with muscular dystrophy. In the present study, the exchangeable potassium and sodium content of the body was determined with the radioactive isotopes potassium42 and sodium22 by the method of isotope dilution as described by Corsa and co-workers: and Forbes and P e r l e ~ . ~ Values in man, as estimated by these authors, indicate that approximately 82 per cent of the total body sodium and 95 per cent of the total body potassium are measured by this method. The quantity of an element which will exchange with its isotope is termed the body content of exchangeable element, which, in the case of complete exchange, is the total amount of element in the body. Although the measurement of the exchangeable sodium and potassium of the body does not correspond to the totaI body content, it does reflect the physiologically active or available amount of these elements.

The Diagnosis of Morphologic Abnormalities of the Human Thyroid Gland by Means of I131

In previous reports (1, 2) a method of studying some of the morphological characteristics of the frontal profile of the human thyroid gland in its normal and abnormal states has been presented. The method uses I131 and the directional scintillation counter (3). The outline of the thyroid gland obtained by this method has been called a “scintigram.” It is the purpose of this paper to present the indications for this procedure and to demonstrate some illustrative cases. Method Briefly, the procedure of handling the patient is as follows: If visual outlining of the thyroid gland is recommended by the Hospital Radioisotope Committee, a dose of carrier-free I131, ranging between 100 and 300 microcuries, is administered orally in capsule form (4). The exact dose used within this range depends upon the avidity of the thyroid gland for the isotope. It has been found desirable to have 60 to 80 microcuries of I131 concentrated in the thyroid. The actual outlining procedure is done twenty-four or forty-eight hours a...