Fred Schwartz

Reaction Time Impairment in Schizophrenia and Affective Illness: The Role of Attention

A young but chronic group of schizophrenic and affective disorders patients was tested for simple reaction time (RT) and RT while engaged in a concurrent task. The affective disorders patients were subdivided by the presence of psychotic features. The results show that extreme slowing of RT is due to psychoticism and is not characteristic of nonpsychotic affective illness. Extreme intrasubject variability, however, was specific to schizophrenia, and may be a trait marker of the disorder.

Negative symptoms and reaction time in schizophrenia

This study explored the association of negative symptoms and reaction time. Negative symptoms were specifically associated with reaction time slowing and variability in schizophrenics, but not in affective disorders. The finding of specificity did not extend to other measures of the deficit syndrome nor to motor performance. An abbreviated version of the negative symptom scale was especially effective in separating groups.

VOLUNTARY MOTOR PERFORMANCE IN PSYCHOTIC DISORDERS: A REPLICATION STUDY

Voluntary motor performance was used to investigate the hypothesis of a continuum of psychosis from depression through schizophrenia. 43 schizophrenic, 36 schizoaffective, 50 major depressive, 20 manic, and 25 nonpsychotic patient controls were tested for tapping speed, finger dexterity, hand grip strength, and neuropsychological motor performance. Sex was included as an independent variable, and the effects of psychotropic drugs were evaluated. A continuum of motor dysfunction from depression through schizophrenia was not obtained. A measure of current psychotic symptoms was not associated with motor or neuropsychological performance. Motor performance was significantly worse in schizophrenic, schizoaffective, and psychotic affective disorders, when compared to nonpsychotic affective disorders. In this final analysis, psychoticism was defined by history. The results are discussed in terms of the hypothesis that psychoticism is a trait that is independent of diagnosis.

The contaminated rorschach response: Formal features

Collected 100 contaminated Rorschach responses and scored for location, form level, presence of human content, populars, color use, movement, and confabulation in an effort to delineate the most salient characteristics of this rarely occurring psychotic and thought-disordered response. The unexpected finding of extremely high form level and much human and popular content, along with relatively little confabulation, points to preserved reality contact in tandem with grossly disordered thought. The relatively high incidence of both color and movement in these responses raises questions about the context in which contaminations are likely to occur. There appears to be a need for further clarification of the contamination response process.

Effects of trihexyphenidyl on plasma chlorpromazine in young schizophrenics

This study investigated the effects of trihexyphenidyl on chlorpromazine (CPZ) plasma levels and clinical state in 20 relatively young schizophrenic patients diagnosed using the DSM-III. Spontaneous changes in CPZ plasma levels over time were also examined. Trihexyphenidyl significantly increased CPZ plasma levels (average 41 %) but did not produce clinical change. The trihexyphenidyl-induced increase in CPZ plasma levels was independent of CPZ oral dosage and of CPZ plasma levels. Chlorpromazine plasma levels decreased non significantly (about 13%) over the four weeks following steady state, but there was marked inter-subject variability, and CPZ levels rose in some subjects. Although identical CPZ doses produced widely variable plasma levels, CPZ plasma levels correlated significantly with oral dose. The views that antiparkinsonian drugs interfere with neuroleptic efficacy, and do so by lowering neuroleptic plasma levels, are questioned.

Laterality in schizophrenia. A reaction time study.

SummaryA laterality study in schizophrenia was carried out by measuring reaction time (RT) in a baseline condition and while subjects were engaged in a concurrent task. In the baseline condition, a clinical measure of psychoticism was associated with differential slowing with the right hand in schizophrenic dextrals but not in a control group of affective dextrals. The concurrent task suppressed the effect of psychoticism on RT performance. The results suggest that left-hemisphere deficits in schizophrenia are state dependent, and so not necessarily due to cortical dysfunction.

Identity integration and ego pathology in disturbed adolescents

Utilizing the Rorschach and the Wechsler, groups of borderline adolescents (n = 26) and adolescents with other personality disorders (n = 26) were compared to determine whether there were differences in magnitude and type of disturbances in ego functioning. The specific aspects of ego functioning that were studied included disturbances in identity integration, reliance on primitive defensive operations, vulnerability to regressive thinking, and lapses in reality appreciation. Results indicated that during adolescence the borderline personality represents a more severe form of character pathology than other personality disorders, as revealed by more disturbances in identity integration, a greater regression to primary-process thinking in unstructured settings, and more frequent lapses in reality testing. This contrast was most striking in the area of identity integration, where identity disturbances tended to be associated with lapses in reality testing in borderline adolescents, while there was essentially no relationship between these two indicators of ego pathology in non-borderline adolescents. This supports the notion that disturbances in identity integration, or the sense of self, form an important part of the borderline diagnosis, even during adolescence.