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Frederick E. Boyer

Pfizer

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Publication

Featured researches published by Frederick E. Boyer.

Bioorganic & Medicinal Chemistry Letters | 2009

Synthesis and structure-activity studies of novel homomorpholine oxazolidinone antibacterial agents.

Ji-Young Kim; Frederick E. Boyer; Allison L. Choy; Michael D. Huband; Paul J. Pagano; J.V.N. Vara Prasad

A novel series of oxazolidinones were synthesized in which the morpholine C-ring of linezolid was replaced with homomorpholine. In addition to investigating the effect of a homomorpholine C-ring on antibacterial activity, the effect of des-, mono-, di-, and tri-fluoro substitution on the phenyl B-ring was investigated as well. Various C-5 functional groups were also examined, including acetamides and triazoles and carboxamides.

Journal of Medicinal Chemistry | 1997

Synthesis of 5,6-dihydro-4-hydroxy-2-pyrones as HIV-1 protease inhibitors : The profound effect of polarity on antiviral activity

Susan Elizabeth Hagen; J.V.N. Vara Prasad; Frederick E. Boyer; John M. Domagala; Edmund L. Ellsworth; Christopher Gajda; Harriet W. Hamilton; Larry J. Markoski; Bruce A. Steinbaugh; Bradley D. Tait; Elizabeth A. Lunney; Peter J. Tummino; Donna Ferguson; Donald Hupe; Carolyn Nouhan; Stephen J. Gracheck; James M. Saunders; Steven VanderRoest

Journal of Medicinal Chemistry | 2000

5, 6-dihydropyran-2-ones possessing various sulfonyl functionalities: Potent nonpeptidic inhibitors of HIV protease

Frederick E. Boyer; J.V.N. Vara Prasad; John M. Domagala; Edmund L. Ellsworth; Christopher Gajda; Susan Elizabeth Hagen; Larry J. Markoski; Bradley D. Tait; Elizabeth A. Lunney; Alexander Palovsky; Donna Ferguson; Neil Graham; Tod P. Holler; Donald Hupe; Carolyn Nouhan; Peter J. Tummino; A. Urumov; Eric Zeikus; Greg Zeikus; Stephen J. Gracheck; James M. Sanders; Steven VanderRoest; Joanne Brodfuehrer; Krishna R. Iyer; Michael W. Sinz; Sergei V. Gulnik; John W. Erickson

Bioorganic & Medicinal Chemistry Letters | 2007

Synthesis and SAR of novel conformationally-restricted oxazolidinones possessing Gram-positive and fastidious Gram-negative antibacterial activity. Part 1: Substituted pyrazoles

Frederick E. Boyer; J.V.N. Vara Prasad; Allison L. Choy; Louis Stanley Chupak; Michael R. Dermyer; Qizhu Ding; Michael D. Huband; Wenhua Jiao; Takushi Kaneko; Vladimir Khlebnikov; Ji-Young Kim; Manjinder S. Lall; Samarendra N. Maiti; Karina Romero; Xiujuan Wu

Journal of Medicinal Chemistry | 2007

Antibacterial oxazolidinones possessing a novel C-5 side chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic acid amide (PF-00422602), a new lead compound.

Toni-Jo Poel; Richard C. Thomas; Wade J. Adams; Paul A. Aristoff; Michael R. Barbachyn; Frederick E. Boyer; Joan K. Brieland; Roger J. Brideau; Joanne Brodfuehrer; Alan P. Brown; Allison L. Choy; Michael R. Dermyer; Michael Dority; Charles W. Ford; Robert C. Gadwood; Debra Hanna; Cai Hongliang; Michael D. Huband; Christopher Huber; Rose Kelly; Ji Young Kim; Joseph P. Martin; Paul J. Pagano; Daniel Ross; Laura Skerlos; Mark C. Sulavik; Tong Zhu; Gary E. Zurenko; J. V. N. Vara Prasad

Bioorganic & Medicinal Chemistry Letters | 2006

Synthesis and structure–activity studies of novel benzocycloheptanone oxazolidinone antibacterial agents

J.V.N. Vara Prasad; Frederick E. Boyer; Lou Chupak; Michael R. Dermyer; Qizhu Ding; K. Gavardinas; Susan Elizabeth Hagen; Michael D. Huband; Wenhua Jiao; Takushi Kaneko; Samarendra N. Maiti; Michael Melnick; Karina Romero; M. Patterson; Xiujuan Wu

Archive | 1997

Dihydropyrones with improved antiviral activity

Frederick E. Boyer; John M. Domagala; Edmund Lee Ellsworth; Christopher Gajda; Susan Elizabeth Hagen; Harriet W. Hamilton; Elizabeth A. Lunney; Larry J. Markoski; Josyula Venkata Nagendra Vara Prasad; Bradley D. Tait

Archive | 2004

Oxazolidinone derivatives n-substituted by a bicyclic ring, for use as antibacterial agents

Louis Stanley Chupak; Takushi Kaneko; Vara Prasad Venkata Nagendra Josyula; Martin Pettersson; Manjinder S. Lall; Susan Elizabeth Hagen; Frederick E. Boyer

Bioorganic & Medicinal Chemistry Letters | 2007

Synthesis and SAR of novel conformationally restricted oxazolidinones possessing gram-positive and fastidious gram-negative antibacterial activity. Part 2: Amino substitutions on heterocyclic D-ring system.

Allison L. Choy; J.V.N. Vara Prasad; Frederick E. Boyer; Michael D. Huband; Michael R. Dermyer

Synthesis | 2007

Synthesis of Pyrazole, Isoxazole, and Aminopyrimidine Ring-Fused Benzothiocycloheptane-Derived Oxazolidinones and Their Corresponding Sulfone Derivatives

Vladimir Khlebnikov; Samarendra N. Maiti; J. V. N. Vara Prasad; Frederick E. Boyer; Mike Stier

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Collaboration

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Allison L. Choy

Pfizer

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J.V.N. Vara Prasad

Pfizer

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Susan Elizabeth Hagen

Pfizer

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Ji-Young Kim

Pfizer

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Michael D. Huband

AstraZeneca

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Bradley D. Tait

Pfizer

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Larry J. Markoski

Pfizer

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Michael R. Dermyer

Pfizer

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Vara Prasad Venkata Nagendra Josyula

Pfizer

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Robert C. Gadwood

Upjohn

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