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Susan Elizabeth Hagen

Pfizer

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Featured researches published by Susan Elizabeth Hagen.

Bioorganic & Medicinal Chemistry Letters | 1999

Nonpeptidic HIV protease inhibitors: 6-Alkyl-5, 6-dihydropyran-2-ones possessing achiral 3-(4-amino/carboxamide-2-t-butyl, 5-methylphenyl thio) moiety: Antiviral activities and pharmacokinetic properties

J. V. N. Vara Prasad; Fred E. Boyer; John M. Domagala; Edmund L. Ellsworth; Christopher Gajda; Susan Elizabeth Hagen; Larry J. Markoski; Bradley D. Tait; Elizabeth A. Lunney; Peter J. Tummino; Donna Ferguson; Tod P. Holler; Donald Hupe; Carolyn Nouhan; Stephen J. Gracheck; Steven VanderRoest; James Saunders; Krishna R Iyer; Michael W. Sinz; Joanne I. Brodfuehrer

Dihydropyran-2-ones possessing amino and carboxamide functionalities on 3-SPh (2-tert-butyl, 5-methyl) ring were synthesized and evaluated for their antiviral activities. Both the enantiomers of inhibitor 15 were synthesized. The in vitro resistance profile, inhibitory activities against cytochrome P450 isozymes and pharmacokinetic properties of inhibitor 15S will be discussed.

Bioorganic & Medicinal Chemistry Letters | 2002

Novel benzthiodiazepinones as antiherpetic agents: SAR improvement of therapeutic index by alterations of the seven-membered ring.

Harriet W. Hamilton; Gisele Nishiguchi; Susan Elizabeth Hagen; John Domagala; Peter Weber; Stephen J. Gracheck; Stefanie L Boulware; Eric C. Nordby; Hidetsura Cho; Takeshi Nakamura; Satoru Ikeda; Wataru Watanabe

A series of novel benzthiodiazepinones was studied as antiherpetic agents. Significant improvements in potency and therapeutic index in a viral replication assay were realized over the starting molecule. The role of stereospecific substitution on the diazepine ring and optimal nitrogen substitution were investigated.

Journal of Medicinal Chemistry | 1988

Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids.

Joseph P. Sanchez; John M. Domagala; Susan Elizabeth Hagen; Carl L. Heifetz; Marland P. Hutt; Jeffry B. Nichols; Ashok K. Trehan

Journal of Medicinal Chemistry | 2001

4-Hydroxy-5,6-dihydropyrones as inhibitors of HIV protease: The effect of heterocyclic substituents at C-6 on antiviral potency and pharmacokinetic parameters

Susan Elizabeth Hagen; John Domagala; Christopher Gajda; Michael Lovdahl; Bradley D. Tait; Eric Wise; Tod P. Holler; Donald Hupe; Carolyn Nouhan; Andrej Urumov; Greg Zeikus; Eric Zeikus; Elizabeth A. Lunney; Alexander Pavlovsky; Stephen J. Gracheck; James Saunders; Steve Vanderroest; Joanne Brodfuehrer

Journal of Medicinal Chemistry | 1993

Quinolone antibacterials containing the new 7-[3-(1-aminoethyl)-1-pyrrolidinyl] side chain : the effects of the 1-aminoethyl moiety and its stereochemical configurations on potency and in vivo efficacy

John M. Domagala; Susan Elizabeth Hagen; Themis Joannides; John S. Kiely; Edgardo Laborde; Mel Conrad Schroeder; Josephine A. Sesnie; Martin A. Shapiro; Mark J. Suto; Steven VanderRoest

Journal of Medicinal Chemistry | 1997

4-hydroxy-5,6-dihydropyrones. 2. Potent non-peptide inhibitors of HIV protease

Bradley D. Tait; Susan Elizabeth Hagen; John M. Domagala; Edmund L. Ellsworth; Christopher Gajda; Harriet W. Hamilton; J. V. N. Vara Prasad; Donna Ferguson; Neil Graham; Donald Hupe; Carolyn Nouhan; Peter J. Tummino; Christine Humblet; Elizabeth A. Lunney; Alexander Pavlovsky; John R. Rubin; Stephen J. Gracheck; Eric T. Baldwin; T. N. Bhat; John W. Erickson; and Sergei V. Gulnik; Beishan Liu

Journal of Medicinal Chemistry | 1997

Synthesis of 5,6-dihydro-4-hydroxy-2-pyrones as HIV-1 protease inhibitors : The profound effect of polarity on antiviral activity

Susan Elizabeth Hagen; J.V.N. Vara Prasad; Frederick E. Boyer; John M. Domagala; Edmund L. Ellsworth; Christopher Gajda; Harriet W. Hamilton; Larry J. Markoski; Bruce A. Steinbaugh; Bradley D. Tait; Elizabeth A. Lunney; Peter J. Tummino; Donna Ferguson; Donald Hupe; Carolyn Nouhan; Stephen J. Gracheck; James M. Saunders; Steven VanderRoest

Journal of Medicinal Chemistry | 2000

5, 6-dihydropyran-2-ones possessing various sulfonyl functionalities: Potent nonpeptidic inhibitors of HIV protease

Frederick E. Boyer; J.V.N. Vara Prasad; John M. Domagala; Edmund L. Ellsworth; Christopher Gajda; Susan Elizabeth Hagen; Larry J. Markoski; Bradley D. Tait; Elizabeth A. Lunney; Alexander Palovsky; Donna Ferguson; Neil Graham; Tod P. Holler; Donald Hupe; Carolyn Nouhan; Peter J. Tummino; A. Urumov; Eric Zeikus; Greg Zeikus; Stephen J. Gracheck; James M. Sanders; Steven VanderRoest; Joanne Brodfuehrer; Krishna R. Iyer; Michael W. Sinz; Sergei V. Gulnik; John W. Erickson

Bioorganic & Medicinal Chemistry Letters | 2007

The synthesis and biological evaluation of novel series of nitrile-containing fluoroquinolones as antibacterial agents

Sean T. Murphy; Heather L. Case; Edmund L. Ellsworth; Susan Elizabeth Hagen; Michael D. Huband; Themis Joannides; Chris Limberakis; Keith R. Marotti; Amy M. Ottolini; Mark R. Rauckhorst; Jeremy T. Starr; Michael Andrew Stier; Clarke B. Taylor; Tong Zhu; Adrian Blaser; William A. Denny; Guo Liang Lu; Jeff B. Smaill; Freddy Rivault

Journal of Medicinal Chemistry | 1988

7-substituted 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3- quinolinecarboxylic acids: synthesis and biological activity of a new class of quinolone antibacterials.

John M. Domagala; Susan Elizabeth Hagen; Carl L. Heifetz; Marland P. Hutt; Thomas F. Mich; Joseph P. Sanchez; Ashok K. Trehan

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Joseph P. Sanchez

Pfizer

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Bradley D. Tait

Pfizer

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Frederick E. Boyer

Pfizer

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Stephen J. Gracheck

Pfizer

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Edmund L. Ellsworth

Pfizer

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Larry J. Markoski

Pfizer

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Donna Ferguson

Pfizer

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Harriet W. Hamilton

Pfizer

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J.V.N. Vara Prasad

Pfizer

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John M. Domagala

Parke-Davis

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