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Dive into the research topics where Fritz Frickel is active.

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Featured researches published by Fritz Frickel.


Journal of Medicinal Chemistry | 2016

Discovery of Narrow Spectrum Kinase Inhibitors: New Therapeutic Agents for the Treatment of COPD and Steroid-Resistant Asthma

Stuart Thomas Onions; Kazuhiro Ito; Catherine Elisabeth Charron; Richard J. Brown; Marie A. Colucci; Fritz Frickel; George William Hardy; Kevin Joly; John King-Underwood; Yasuo Kizawa; Ian Knowles; P. John Murray; Andrew Richard Novak; Anjna Rani; Garth Rapeport; Alun John Smith; Peter N. Strong; David Michel Adrien Taddei

The discovery of a novel series of therapeutic agents that has been designed and optimized for treating chronic obstructive pulmonary disease is reported. The pharmacological strategy was based on the identification of compounds that inhibit a defined subset of kinase enzymes modulating inflammatory processes that would be effective against steroid refractory disease and exhibit a sustained duration of action after inhaled delivery.


Cancer Research | 1983

Structure-Activity Relationships of a New Series of Retinoidal Benzoic Acid Derivatives as Measured by Induction of Differentiation of Murine F9 Teratocarcinoma Cells and Human HL-60 Promyelocytic Leukemia Cells

Sidney Strickland; T. R. Breitman; Fritz Frickel; Axel Nürrenbach; Erich Hädicke; Michael B. Sporn


Chemische Berichte | 1978

Die Struktur von Cimetidin (N″-Cyan-N-Methyl-N′-[2-[(5-methyl-1H-imidazol-4-yl)methylthio]ethyl]guanidin), einem Histamin H2-Rezeptor-Antagonist

Erich Hädicke; Fritz Frickel; Albrecht Franke


Chemische Berichte | 1980

Stereoselektive Synthesen von Alkoholen, I. C C‐Verknüpfende Synthese von Allylalkoholen aus Aldehyden und Ketonen

Reinhard W. Hoffmann; Siegfried Goldmann; Norbert Maak; Rainer Gerlach; Fritz Frickel; Gertrud Steinbach


Journal of Medicinal Chemistry | 1981

2-(Isoxazolylethenyl)phenoxypropanolamines: a new class of beta-receptor antagonists with antihypertensive activity.

Albrecht Franke; Fritz Frickel; Josef Gries; Dieter Lenke; Rainer Schlecker; Peter Dr Thieme


Angewandte Chemie | 1977

5‐Methoxy‐semibullvalen

Reinhard W. Hoffmann; Norbert Hauel; Fritz Frickel


Chemische Berichte | 1975

Synthese 2,4‐disubstituierter Bicyclo[3.1.0]hexane

Reinhard W. Hoffmann; Fritz Frickel; Klaus Blatt


ChemInform | 1981

NEW β-SYMPATHOLYTIC AGENTS: SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF ISOMERIC BENZOTHIAZOLE AND BENZOXAZOLE DERIVATIVES

A. Franke; Fritz Frickel; J. Gries; H. D. Lehmann; D. Lenke; U. Ohnsorge


ChemInform | 1980

STEREOSELECTIVE SYNTHESIS OF ALCOHOLS. I. CARBON-CARBON BOND-FORMING SYNTHESIS OF ALLYL ALCOHOLS FROM ALDEHYDES OR KETONES

Reinhard W. Hoffmann; S. Goldmann; N. Maak; R. Gerlach; Fritz Frickel; Gertrud Steinbach


Archive | 1986

N-SUBSTITUTED IMIDAZOLE DERIVATIVES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE

Bernd Ostersehlt; Albrecht Franke; Fritz Frickel; Marco Thyes; Ludwig Friedrich; Josef Gries; Dieter Dr Prof Lenke

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Gertrud Steinbach

Darmstadt University of Applied Sciences

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Klaus Blatt

Darmstadt University of Applied Sciences

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