Fu-Yue Zeng
Sanford-Burnham Institute for Medical Research
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Publication
Featured researches published by Fu-Yue Zeng.
Bioorganic & Medicinal Chemistry Letters | 2012
Patrick R. Maloney; Pasha Khan; Michael Hedrick; Palak Gosalia; Monika Milewski; Linda Li; Gregory P. Roth; Eduard Sergienko; Eigo Suyama; Eliot Sugarman; Kevin Nguyen; Alka Mehta; Stefan Vasile; Ying Su; Derek Stonich; Hung Nguyen; Fu-Yue Zeng; Arianna Mangravita Novo; Michael Vicchiarelli; Jena Diwan; Thomas Dy Chung; Layton H. Smith; Anthony B. Pinkerton
The recently discovered apelin/APJ system has emerged as a critical mediator of cardiovascular homeostasis and is associated with the pathogenesis of cardiovascular disease. A role for apelin/APJ in energy metabolism and gastrointestinal function has also recently emerged. We disclose the discovery and characterization of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221), a potent APJ functional antagonist in cell-based assays that is >37-fold selective over the closely related angiotensin II type 1 (AT1) receptor. ML221 was derived from an HTS of the ~330,600 compound MLSMR collection. This antagonist showed no significant binding activity against 29 other GPCRs, except to the κ-opioid and benzodiazepinone receptors (<50/<70%I at 10 μM). The synthetic methodology, development of structure-activity relationship (SAR), and initial in vitro pharmacologic characterization are also presented.
Archive | 2013
Patrick Maloney; Pasha Khan; Michael Hedrick; Palak Gosalia; Monika Milewski; Linda Li; Gregory P. Roth; Eduard Sergienko; Eigo Suyama; Eliot Sugarman; Kevin Nguyen; Alka Mehta; Stefan Vasile; Ying Su; Derek Stonich; Hung Nguyen; Fu-Yue Zeng; Arianna Mangravita Novo; Michael Vicchiarelli; Jena Diwan; Thomas Dy Chung; Anthony B. Pinkerton; Layton H. Smith
Archive | 2014
Jiwen Zou; Santhi Ganji; Ian Pass; Robert Ardecky; Mahesh Peddibhotla; Milan Loribelle; Susanne Heynen-Genel; Stefan Vasile; Eigo Suyama; Siobhan Malany; Arianna Mangravita-Novo; Michael Vicchiarelli; Danielle McAnally; Anton Cheltsov; Stonich Derek; Shenghua Shi; Ying Su; Fu-Yue Zeng; Anthony B. Pinkerton; Layton H. Smith; Sylvia Kim; Hung Ngyuen; Jena Diwan; Andrew J. Heisel; Rosalind Coleman; Patrick M. McDonough; Thomas Dy Chung
Archive | 2014
Robert Ardecky; Gavin Magnuson; Jiwen Zou; Santhi Ganji; Brock Brown; Tram Ngo; Julia Lee; Fu-Yue Zeng; Qing Sun; Derek Stonich; Sumeet Salaniwal; Tomoyo Sakata; Paul G. Rack; Jennifer K. T. Casabar; Arianna Mangravita-Novo; Layton H. Smith; Eduard Sergienko; Thomas Dy Chung; Anthony B. Pinkerton; Ian Pass; James K. Chen
Archive | 2014
Jiwen Zou; Santhi Ganji; Ian Pass; Robert Ardecky; Mahesh Peddibhotla; Milan Loribelle; Susanne Heynen-Genel; Stefan Vasile; Eigo Suyama; Siobhan Malany; Arianna Mangravita-Novo; Michael Vicchiarelli; Danielle McAnally; Anton Cheltsov; Stonich Derek; Shenghua Shi; Ying Su; Fu-Yue Zeng; Anthony B. Pinkerton; Layton H. Smith; Sylvia Kim; Hung Ngyuen; Jena Diwan; Andrew J. Heisel; Rosalind Coleman; Patrick M. McDonough; Thomas Dy Chung
Archive | 2014
Jiwen Zou; Santhi Ganji; Ian Pass; Robert Ardecky; Mahesh Peddibhotla; Milan Loribelle; Susanne Heynen-Genel; Stefan Vasile; Eigo Suyama; Siobhan Malany; Arianna Mangravita-Novo; Michael Vicchiarelli; Danielle McAnally; Anton Cheltsov; Stonich Derek; Shenghua Shi; Ying Su; Fu-Yue Zeng; Anthony B. Pinkerton; Layton H. Smith; Sylvia Kim; Hung Ngyuen; Jena Diwan; Andrew J. Heisel; Rosalind Coleman; Patrick M. McDonough; Thomas Dy Chung
Archive | 2014
Jiwen Zou; Santhi Ganji; Ian Pass; Robert Ardecky; Mahesh Peddibhotla; Milan Loribelle; Susanne Heynen-Genel; Stefan Vasile; Eigo Suyama; Siobhan Malany; Arianna Mangravita-Novo; Michael Vicchiarelli; Danielle McAnally; Anton Cheltsov; Stonich Derek; Shenghua Shi; Ying Su; Fu-Yue Zeng; Anthony B. Pinkerton; Layton H. Smith; Sylvia Kim; Hung Ngyuen; Jena Diwan; Andrew J. Heisel; Rosalind Coleman; Patrick M. McDonough; Thomas Dy Chung
Archive | 2014
Jiwen Zou; Santhi Ganji; Ian Pass; Robert Ardecky; Mahesh Peddibhotla; Milan Loribelle; Susanne Heynen-Genel; Stefan Vasile; Eigo Suyama; Siobhan Malany; Arianna Mangravita-Novo; Michael Vicchiarelli; Danielle McAnally; Anton Cheltsov; Stonich Derek; Shenghua Shi; Ying Su; Fu-Yue Zeng; Anthony B. Pinkerton; Layton H. Smith; Sylvia Kim; Hung Ngyuen; Jena Diwan; Andrew J. Heisel; Rosalind Coleman; Patrick M. McDonough; Thomas Dy Chung
Archive | 2014
Jiwen Zou; Santhi Ganji; Ian Pass; Robert Ardecky; Mahesh Peddibhotla; Milan Loribelle; Susanne Heynen-Genel; Stefan Vasile; Eigo Suyama; Siobhan Malany; Arianna Mangravita-Novo; Michael Vicchiarelli; Danielle McAnally; Anton Cheltsov; Stonich Derek; Shenghua Shi; Ying Su; Fu-Yue Zeng; Anthony B. Pinkerton; Layton H. Smith; Sylvia Kim; Hung Ngyuen; Jena Diwan; Andrew J. Heisel; Rosalind Coleman; Patrick M. McDonough; Thomas Dy Chung
Archive | 2014
Jiwen Zou; Santhi Ganji; Ian Pass; Robert Ardecky; Mahesh Peddibhotla; Milan Loribelle; Susanne Heynen-Genel; Stefan Vasile; Eigo Suyama; Siobhan Malany; Arianna Mangravita-Novo; Michael Vicchiarelli; Danielle McAnally; Anton Cheltsov; Stonich Derek; Shenghua Shi; Ying Su; Fu-Yue Zeng; Anthony B. Pinkerton; Layton H. Smith; Sylvia Kim; Hung Ngyuen; Jena Diwan; Andrew J. Heisel; Rosalind Coleman; Patrick M. McDonough; Thomas Dy Chung