Fumi Toriyama

INTRANUCLEAR TONOFILAMENTS IN A CASE OF GIANT CONDYLOMATA ACUMINATA (BUSCHKE AND LOEWENSTEIN)

Intranuclear filamentous inclusions were seen electron microscopically in a small number of cells of the granular layer in a patient with giant condylomata acuminata. These inclusions were identified as cytoplasmic tonofilaments in a keratinocyte by their electron‐dense bundles composed of fine fibers which measured about 60 angstroms in diameter, and by the lack of periodicity in these fibers.

Attenuation of an adult T-cell leukemia skin lesion after treatment of a concomitant herpes simplex infection: a case study

We report the development and treatment of eczema herpeticum in a 51-year-old male suffering from adult T-cell leukemia (ATL). Lesions of eczema herpeticum coexisted with the skin lesions of ATL. Treatment of eczema herpeticum resulted in a concomitant improvement in the symptoms of ATL, including a reduction in the size of the ATL plaques, for over 2 months before relapse.

Clinicopathological reevaluation of squamous cell carcinoma of the lip

口唇部に生じた有棘細胞癌 (SCC) は転移しやすく, 生命の危険性が高いとされる。ところが, その臨床症状と病理所見を正しく捉え, 早期に適切な治療が行われていない可能性がある。自験2例を通して, 皮膚科初診から手術までの経過を検討した。2例とも臨床的にSCCを疑われ, 複数回の皮膚生検を施行されたが, 長い間皮膚癌の診断はなされなかった。その結果, 1例は脈管侵襲と肺転移を生じ, 他の1例は筋層浸潤という予後不良なSCCとなった。したがって, 口唇部SCCの病初期は臨床症状および病理所見が良性と誤られることがあると知るべきである。すなわち治療が遅れがちとなることが口唇部SCCの予後の悪さを引き起こしていると思われる。臨床症状の腫瘤形成と, 病理所見の細胞異型が弱い点は要注意であり, Verrucous carcinomaと診断されることがしばしばある。このような症例はやがて時間の経過とともに悪性度を増し, 重症化するものと推測した。

Chromosome abnormalities in skin fibroblasts probably induced by an anti-cancer drug.

Chromosome findings in cultured skin fibroblasts from a patient treated with an anti‐cancer drug, pepleomycin sulfate, for his penis cancer are reported. In two batches of specimens (days 16 and 34, respectively), out of 120 cells examined, a total of 26 abnormal cells (21.7%) were found with no common chromosome abnormalities; there were no clones. This cytogenetic pattern of abnormalities without clones in cultured skin fibroblasts differs from that seen in congenital disease or radiation‐exposed skin fibroblasts. It is suggested that the anti‐cancer agent is the most likely etiological factor for these uncloned chromosome abnormalities in cultured skin fibroblasts.