G. Bram

Alkylation of potassium acetate in “dry media” thermal activation in commercial microwave ovens

Abstract Microwave irradiation using commercial domestic ovens is very efficient to activate potassium acetate on alumina in the absence of solvent (“dry media”) giving rise to remarkable rate enhancements in alkylation reactions with long chain halides. These reactions can be performed quantitatively on appreciable amounts of materials in open standard pyrex vessels.

Inorganic solids in dry media an efficient way for developing microwave irradiation activated organic reactions

Abstract “Dry media” microwave irradiation accelerates pinacol rearrangement (on montmorillonite) or acetate alkylation (on alumina or silicagel) without the hazards due to high pressures in vessels when using solvents.

Microwave Irradiation Plus Solid-Liquid Phase Transfer Catalysis Without Solvent: Further Improvement in Anionic Activation

Abstract Owing to cumulative effects of microwave irradiation and solid-liquid PTC without solvent methodology, conditions for alkylations of potassium acetate by n-octyl or n-cetyl halides are nearly quantitative within 2 minutes on appreciable quantities.

Easy alkylation of purine bases by solid-liquid phase transfer catalysis without solvent. : structural analysis by 2D heteronuclear 1H 13C correlated nmr spectroscopy.

Abstract Solid-liquid PTC without added organic solvent promotes alkylation of purine derivatives leading in particular to an efficient synthesis of the antiviral DHPA. The location of the substituent on the ring was determined by analysis of coupling interactions through 2D δ-δ heteronuclear 1H 13C correlated NMR spectroscopy.

Easy and efficient anion alkylations in solid-liquid PTC conditions

Abstract Alkylation of anionic nucleophiles such as potassium acetate or potassium indole can be achieved in good yields without solvent either in the presence of NBu 4 Br and small amounts of TiO 2 or in the presence of Aliquat 336 (Oct 3 MeN + Cl − ).

Catalyse par transfert de phase solide-liquide sans solvant : application a la reaction de michael

Abstract Solid-liquid phase transfer catalysis without added organic solvent efficiently promotes MICHAEL reactions. The method is applied here to the addition of acetylacetone, methylacetoacetate and fluorene anions on hindered acceptors.

Easy Michael Addition by Solid-Liquid Phase Transfer Catalysis Abnormal Reaction of N-Acetylaminomalonate

Abstract Solid-liquid phase transfer catalysis (PTC) without added solvent efficiently promotes Michael addition of substituted malonates on hindered acceptors. A rearrangement of adducts formed by addition of diethyl N-acetylaminomalonate is described.

Easy and Efficient Heterogeneous Nucleophilic Fluorination without Solvent

Abstract In the absence of solvent, either [NBu4 F,3H2 O] or [CsF in the presence of catalytic amounts of a phase transfer catalyst] were found to be effective and practical reagents for the fluorination of several organic halides under mild conditions.

18-Crown-6–potassium–ethyl acetoacetate enolate. X-Ray structure determination

The crystal structure of the title compound shows that it forms a distinct molecule; K+ is co-ordinated to the six oxygen atoms of the crown and to the two oxygen atoms of the U shaped enolate.

Selective N-prop-2-ynylation of heterocycles induced by solid–liquid phase transfer catalysis without solvent and use of solid inorganic supports

Complementary processes promote the N-prop-2-ynylation of heterocycles: solid-liquid phase transfer catalysis without added solvent in the presence or absence of alumina or titanium dioxide and alkylation on ‘basic’ alumina in ‘dry media’.