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Dive into the research topics where G. Fürst is active.

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Featured researches published by G. Fürst.


Journal of Computer Assisted Tomography | 1994

MRI-guided LASER-induced interstitial thermotherapy of cerebral neoplasms

Thomas Kahn; Martin Bettag; Frank Ulrich; Hans-Joachim Schwarzmaier; Ralf Schober; G. Fürst; U. Mödder

Objective Laser-induced interstitial thermotherapy (LITT) using a neodymium:yttrium aluminum garnet (Nd: YAG) laser is a new therapeutic approach in the treatment of brain tumors. The purpose of our study was to determine the value of MRI in monitoring LITT. Materials and Methods Eight patients with intracerebral tumors were treated with LITT. The light guide was inserted via an applicator sheath that was implanted stereotaxically with CT guidance. The laser irradiation was performed within the MR unit and monitored by repetitive measurements of a T1-weighted 2D-FLASH sequence. Results During therapy in all patients, typical changes of signal intensity were seen. A gradually increasing central zone of high signal intensity was surrounded by an increasing peripheral area of reduced signal intensity. The diameter of an enhancing rim at the outer border of the peripheral area after Gd-DTPA was considered as the total lesion size. The lesion size as determined on 2D-FLASH scans during LITT accounted for 88–100% (mean 93.5%) of total lesion size on T1-weighted images after Gd-DTPA acquired immediately after therapy. On T2-weighted images the signal intensities of the two zones were vice versa. Follow-up studies showed a decrease of total lesion size (15–87%). Conclusion Our results demonstrate that MRI is feasible and effective in monitoring LITT. However, the role of LITT in the therapeutic workup of brain tumors still has to be defined in future clinical studies.


Acta neurochirurgica | 1991

Stereotactic Laser Therapy in Cerebral Gliomas

Martin Bettag; Frank Ulrich; Ralf Schober; G. Fürst; K. J. Langen; Michael Sabel; Jürgen C. W. Kiwit

The 1.06 micron Nd:YAG laser and a new fiberoptic delivery system, the Interstitial Thermo-Therapy (ITT) laser fibre, allows stereotactic interstitial irradiation of cerebral tumours. In experimental rat brain studies we found typical laser-tissue effects with a central necrosis and a sharply demarcated oedema towards the normal brain. The size of the lesion depended on the energy and exposure time applied. In a pilot series we treated 5 patients with cerebral gliomas WHO grade II-III in functionally important regions and monitored the therapeutic effects by MR imaging and PET scan. Early post-operative results showed irreversible necrotic changes in the tumour centre and reversible oedematous changes at the tumour margin. Long-term results will show if stereotactic interstitial laser therapy is a useful supplementary method in the treatment of malignant cerebral tumours.


Pacing and Clinical Electrophysiology | 2001

Long‐Term Follow‐Up of Left Ventricular Pacing via a Posterior Cardiac Vein After Mechanical Tricuspid Valve Replacement

Joachim Winter; H. Gramsch-Zabel; G. Fürst; Jens-Albrecht Koch; Norbert Zimmermann; Emmeran Gams

WINTER, J., et al.: Long‐Term Follow‐Up of Left Ventricular Pacing via a Posterior Cardiac Vein After Mechanical Tricuspid Valve Replacement. Permanent cardiac pacing was recommended in a 66‐year‐old woman with mechanical prosthetic mitral and tricuspid valves. To avoid a thoracotomy, a conventional endocardial lead was inserted with a steerable stylet (Locator) into the posterior cardiac vein via the right cephalic vein. Four weeks later, lead dislodgement required reoperation. The lead position remained stable up to 29 months.


Archive | 1991

Gadolinium-DTPA-enhanced MRI and positron emission tomography of stereotactic laser-induced interstitial thermal therapy in cerebral gliomas

Martin Bettag; Frank Ulrich; G. Fürst; K.-J. Langen; N. Roosen; Jürgen C. W. Kiwit; S. Hessel; U. Mödder; Wolfgang J. Bock

Stereotactic laser-induced interstitial thermal therapy (SLIITT) is a new method for inducing local hyperthermia in cerebral tumours. As pre- and early post-therapeutic evaluations in five patients with cerebral gliomas WHO grade II and III treated by SLIITT we performed ga-dolinium-DTPA-enhanced MRI and positron emission tomography (PET). We found that MRI is a sensitive tool for mapping the spatial and temporal distribution of laser-tissue interactions. PET studies using 2-(18F)fluoro-2-D-de-oxyglucose showed typical changes in glucose metabolism of the glioma. Both investigations seem to reveal irreversible laser effects in the centre of the tumour probably due to a coagulative necrosis and reversible effects at the tumour margin probably caused by reparative processes after SLIITT. It could be demonstrated that laser-tissue interactions progress with time, depending on laser energy and exposure time.


Journal of Medical Imaging and Radiation Oncology | 2011

Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) and morphologic MRI of cartilage in the long-term follow-up after Legg-Calvé-Perthes disease (LCPD).

Arne Holstein; Christoph Zilkens; Bernd Bittersohl; Marcus Jäger; Tanja Haamberg; Tallal C. Mamisch; Rs Lanzman; Patric Kröpil; Dirk Blondin; Rüdiger Krauspe; Gerald Antoch; G. Fürst; Falk Miese

Introduction: The purpose of the present study was to evaluate the feasibility of delayed gadolinium‐enhanced magnetic resonance imaging of cartilage (dGEMRIC) in the detection of cartilage changes versus morphologic imaging in the long‐term course of Legg–Calvé–Perthes disease (LCPD).


Chirurg | 2000

Die akute Aortendissektion

B. T. Müller; K. Grabitz; G. Fürst; W. Sandmann

Abstract.Aim of the study: About 30 % of the patients with acute aortic dissection suffer from organ or limb ischemia. We analyzed the influence of ischemic localization and method of operative treatment (aortic fenestration or extraanatomic bypass revascularization) on morbidity and mortality. Patients and methods: From 1 May 1987 to 31 December 1998 21 patients with 24 vascular complications such as renal or intestinal ischemia, lower extremity ischemia and paraplegia following acute aortic dissection were treated at our institution. Recruitment was retrospective in 16 and prospective in 5 patients. In 5 patients (24 %) the complication was associated with Stanford A, in 16 ( 76 %) with Stanford B dissection. Ten patients (48 %) complained of malperfusion of only one region, whereas 11 patients (52 %) suffered from ischemia of two or three different regions. Aortic fenestration and resection of the dissected membrane was performed in nine cases (37 %). Fifteen patients (63 %) were treated with extraanatomic bypass techniques. Results: One third of the patients died, four of them due to aortic penetration or perforation and two due to visceral ischemia. During follow-up of 32 (1–110) months two patients developed aortic complications. One died of aortic perforation, while the other developed a thoracoabdominal aneurysm and had to be treated by a tube graft replacement. Conclusions: Outcome depended more on the spontaneous course of aortic dissection and on prompt diagnosis and therapy of the complications than on the different operative techniques.Zusammenfassung.Fragestellung: Im Rahmen einer akuten Stanford A- oder B-Aortendissektion erleiden bis zu 30 % der Patienten eine Organ- oder Extremitätendurchblutungsstörung. Wir analysierten den Einfluß der Ischämielokalisation und der unterschiedlichen operativen Verfahren (extra-anatomische Bypassverfahren versus Fensterung und Membranresektion) auf die Morbidität und Letalität der Erkrankung. Patienten und Methoden: Vom 01.05.1987 bis 31.12.1998 wurden 21 Patienten mit 24 ischämischen Komplikationen einer akuten Aortendissektion, wie Nieren-oder Visceralischämie, akuter Extremitätenischämie oder Paraplegie versorgt. Die Datenerfassung erfolgte bei 16 Patienten retrospektiv und bei weiteren 5 Patienten prospektiv. Bei 5 Patienten (24 %) trat die ischämische Komplikation nach einer Stanford A-Dissketion und bei 16 Patienten (76 %) nach einer Stanford B-Dissektion auf. Während bei 10 Patienten (48 %) nur eine Gefäßregion (am häufigsten die Extremitäten) minderperfundiert waren, litten 11 (52 %) Patienten unter einer Ischämie in bis zu 3 verschiedenen Gefäßprovinzen. Die Revascularisation erfolgte in 9 (37 %) Fällen durch eine aortale Fensterung und Membranresektion und in 15 Fällen (63 %) durch einen extraanatomischen Bypass. Ergebnisse: Ein Drittel der Patienten verstarben während des stationären Aufenthaltes, 4 davon an einer Aortenpenetration oder -perforation, 2 an den Folgen einer Mesenterialischämie. Nur einer von 7 Patienten mit renalen Perfusionstörungen blieb dauerhaft dialysepflichtig. Während der Nachbeobachtungszeit von 32 (1–110) Monaten entwickelten 2 Patienten (14 %) aortale Komplikationen. Einer verstarb an den Folgen einer Aortenperforation, während ein anderer ein thorakoabdominelles Aortenaneurysma entwickelte, das durch ein Aorteninterponat ersetzt werden mußte. Schlußfolgerungen: Die Operationsmorbidität und -letalität der Patienten waren weniger von dem durchgeführten Operationsverfahren, als von dem Zeitpunkt der chirurgischen Therapie sowie dem Spontanverlauf der Aortendissektion selbst abhängig.


Chirurg | 2008

Ösophagusnekrose nach endovaskulärer Versorgung eines rupturierten thorakalen Aortenaneurysmas

Claudio Rascanu; Barbara Theresia Weis-Müller; G. Fürst; D. Grotemeyer; W. Sandmann

We report a case of acute esophageal necrosis after endovascular stenting for acute rupture of a thoracic aortic aneurysm into the mediastinum caused by mediastinal compartment syndrome and overstenting of intercostal arteries.ZusammenfassungWir berichten über eine akute Ösophagusnekrose, die nach endovaskulärer Therapie eines ins Mediastinum perforierten thorakalen Aortenaneurysma auftrat. Ursache ist eine Ösophagusminderdurchblutung hervorgerufen durch ein mediastinales Kompartmentsyndrom in Kombination mit dem Überstenten von Interkostalarterien.AbstractWe report a case of acute esophageal necrosis after endovascular stenting for acute rupture of a thoracic aortic aneurysm into the mediastinum caused by mediastinal compartment syndrome and overstenting of intercostal arteries.


Chirurg | 2009

[Esophageal necrosis following endovascular treatment of a ruptured thoracal aortic aneurism: caused by mediastinal compartment syndrome].

Claudio Rascanu; Barbara Theresia Weis-Müller; G. Fürst; D. Grotemeyer; W. Sandmann

We report a case of acute esophageal necrosis after endovascular stenting for acute rupture of a thoracic aortic aneurysm into the mediastinum caused by mediastinal compartment syndrome and overstenting of intercostal arteries.ZusammenfassungWir berichten über eine akute Ösophagusnekrose, die nach endovaskulärer Therapie eines ins Mediastinum perforierten thorakalen Aortenaneurysma auftrat. Ursache ist eine Ösophagusminderdurchblutung hervorgerufen durch ein mediastinales Kompartmentsyndrom in Kombination mit dem Überstenten von Interkostalarterien.AbstractWe report a case of acute esophageal necrosis after endovascular stenting for acute rupture of a thoracic aortic aneurysm into the mediastinum caused by mediastinal compartment syndrome and overstenting of intercostal arteries.


Chirurg | 2007

Pulmonary embolism and deep vein thrombosis in the inferior vena cava affected by a rare anomaly

J. Rudolph; Michael Pillny; K. Grabitz; G. Fürst; W. Sandmann

ZusammenfassungDie Linksaszension ist mit einer Prävalenz von 0,2–0,5% eine seltene Fehlbildung der unteren Hohlvene. Eine Kombination dieser Anlagestörung mit einer Thrombosierung wurde bisher nur in Einzelfällen beschrieben. Wir berichten über den Fall einer 24-jährigen Patientin mit V.-cava-inferior- (VCI-)Thrombose und rezidivierender Lungenembolie bei VCI-Transposition. Nach venöser Thrombektomie (VT) der Becken-Bein- und VCI-Strombahn gestaltete sich der weitere Verlauf unauffällig. Das diagnostische und therapeutische Vorgehen werden anhand der Literatur dargestellt.AbstractPersistent left-sided inferior vena cava (VCI) is a rare venous anomaly, its prevalence being estimated at 0.2–0.5%. Thrombotic occlusion of a VCI has been reported in only a few of these cases. We report the case of a 24-year old woman who suffered an acute thrombosis in a left-sided VCI and recurrent pulmonary embolism. After thrombectomy the course was uneventful. The diagnostic approach and the treatment strategy are discussed with reference to the literature.


Chirurg | 2006

Embolisierende Thrombose bei Fehlbildung der V. cava inferior

J. Rudolph; Michael Pillny; K. Grabitz; G. Fürst; W. Sandmann

ZusammenfassungDie Linksaszension ist mit einer Prävalenz von 0,2–0,5% eine seltene Fehlbildung der unteren Hohlvene. Eine Kombination dieser Anlagestörung mit einer Thrombosierung wurde bisher nur in Einzelfällen beschrieben. Wir berichten über den Fall einer 24-jährigen Patientin mit V.-cava-inferior- (VCI-)Thrombose und rezidivierender Lungenembolie bei VCI-Transposition. Nach venöser Thrombektomie (VT) der Becken-Bein- und VCI-Strombahn gestaltete sich der weitere Verlauf unauffällig. Das diagnostische und therapeutische Vorgehen werden anhand der Literatur dargestellt.AbstractPersistent left-sided inferior vena cava (VCI) is a rare venous anomaly, its prevalence being estimated at 0.2–0.5%. Thrombotic occlusion of a VCI has been reported in only a few of these cases. We report the case of a 24-year old woman who suffered an acute thrombosis in a left-sided VCI and recurrent pulmonary embolism. After thrombectomy the course was uneventful. The diagnostic approach and the treatment strategy are discussed with reference to the literature.

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W. Sandmann

University of Düsseldorf

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K. Grabitz

University of Düsseldorf

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Claudio Rascanu

University of Düsseldorf

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D. Grotemeyer

University of Düsseldorf

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Arne Holstein

University of Düsseldorf

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B. T. Müller

University of Düsseldorf

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Falk Miese

University of Düsseldorf

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