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Dive into the research topics where G. L. Rusinov is active.

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Featured researches published by G. L. Rusinov.


Pharmaceutical Chemistry Journal | 2006

Synthesis and anti-tuberculous activity of diesters based on isosteviol and dicarboxylic acids

V. E. Kataev; O. I. Militsina; I. Yu. Strobykina; G. I. Kovylyaeva; R. Z. Musin; O. V. Fedorova; G. L. Rusinov; M. N. Zueva; G. G. Mordovskoi; A. G. Tolstikov

Diesters based on isosteviol and dicarboxylic acids were synthesized and tested for antituberculous activity. Isosteviol and some of its derivatives exhibit appreciable tuberculostatic properties in vitro, the activity being dependent on the length of the polymethylene spacer connecting two ent-beyeran fragments. The mechanism of the antituberculous action of isosteviol derivatives are discussed.


Russian Chemical Bulletin | 2012

Synthesis, structure, electrochemical and magnetic properties of 2,6-bis(5-trifluoromethylpyrazol-3-yl)pyridine and its NiII complexes

E. F. Khmara; D. L. Chizhov; A. A. Sidorov; G. G. Aleksandrov; P. A. Slepukhin; M. A. Kiskin; K. L. Tokarev; V. I. Filyakova; G. L. Rusinov; I. V. Smolyaninov; A. S. Bogomyakov; D. V. Starichenko; Yu. N. Shvachko; A. V. Korolev; I. L. Eremenko; V. N. Charushin

Abstract2,6-Bis(5-trifluoromethylpyrazol-3-yl)pyridine (H2L) and its mono-, tri-, and tetranuclear NiII complexes were synthesized for the first time. All the obtained compounds were characterized by single-crystal X-ray diffraction analysis. In the complexes, 2,6-bis(5-trifluoromethylpyrazol-3-yl)pyridine exists in the neutral and dianionic forms and exhibits different coordination modes (κ3-, μ2-κ3:κ1-, and μ3-κ3:κ1:κ1). The electrochemical and magnetic properties of all compounds were studied. The tetranuclear NiII complex with the L2− dianion is reduced in two sequential reversible one-electron steps.


Chemistry of Heterocyclic Compounds | 2013

1,2,4,5-Tetrazines and Azolo[1,2,4,5]tetrazines: Synthesis and Reactions with Nucleophiles

S. G. Tolshchina; G. L. Rusinov; V. N. Charushin

The literature data are summarized for synthetic methods and nucleophilic transformations of 1,2,4,5-tetrazines and azolo[1,2,4,5]tetrazines published predominantly from 1995 until 2012.


RSC Advances | 2016

C–H functionalization of azines. Anodic dehydroaromatization of 9-(hetero)aryl-9,10-dihydroacridines

A. V. Shchepochkin; O. N. Chupakhin; V. N. Charushin; D. V. Steglenko; Vladimir I. Minkin; G. L. Rusinov; A. I. Matern

Data on anodic dehydroaromatization of 9,10-dihydroacridines, bearing aryl and heteroaryl fragments, are presented. Effects of both electron-donating and electron-withdrawing substituents on the current–voltage characteristics of these compounds have been established. The experimental data proved to be in a good agreement with quantum chemical calculations. A simple and convenient method for the electrochemical conversion of dihydroacridines into the corresponding 9-(hetero)aryl-N-methylacridinium salts has been advanced.


Russian Chemical Bulletin | 2014

Synthesis of 5-(het)aryl- and 4,5-di(het)aryl-2-(thio)morpholinopyrimidines from 2-chloropyrimidine via SNH and cross-coupling reactions

Ekaterina M. Cheprakova; Egor V. Verbitskiy; M. A. Ezhikova; M. I. Kodess; M. G. Pervova; P. A. Slepukhin; Maria S. Toporova; M. A. Kravchenko; I. D. Medvinskiy; G. L. Rusinov; V. N. Charushin

It has been shown that various combinations of nucleophilic aromatic substitution of hydrogen (SNH), SNipso and the microwave-assisted Suzuki cross-coupling reactions are a versatile method for the synthesis of 5-(het)aryl-2-(thio)morpholinopyrimidine and 4,5-di(het)aryl-2-(thio)morpholinopyrimidine derivatives. All synthesized pyrimidines were found to be active in micromolar concentrations in vitro against Mycobacterium tuberculosis H37Rv.


Journal of Sol-Gel Science and Technology | 2014

Catalysts for enantioselective Biginelli reaction based on the composite silica-zirconia xerogels prepared using different zirconium sources

Igor Krivtsov; Yu. A. Titova; Marina Ilkaeva; Viacheslav Avdin; O. V. Fedorova; S. A. Khainakov; José R. García; G. L. Rusinov; V. N. Charushin

AbstractThe composite silica-zirconia xerogels have been prepared via sol–gel method using zirconium oxychloride, oxynitrate, acetate and sodium silicate as the precursors. The prepared materials have been characterized using FTIR, TG/DTA, EDX and surface area analyses. It has been established that surface area of silica-zirconia xerogels significantly depends on the zirconium source, but phase transitions and structural features of the xerogels seem to be unaffected by the choice of the zirconia precursor. Prepared xerogels increase the activity of chiral inductor in the asymmetric Biginelli reaction. The anion of the zirconium salt adsorbed on the surface of the synthesized material and the presence of Si–O–Zr heterolinkages determines the reaction yield. The highest chemo- and enantioselectivity towards formation of ee isomer have been provided by the catalyst prepared from zirconium oxychloride.


Chemistry of Heterocyclic Compounds | 2014

Diaryl-Substituted Polyethers with Acetoacet-Anilide Fragment in the Synthesis of Dihydro-Pyrimidine-Containing Podands*

E. S. Radionova; Yu. A. Titova; Maxim L. Isenov; O. V. Fedorova; G. L. Rusinov; V. N. Charushin

The interaction of ortho-aminoaryl polyethers, derivatives of mono-, di-, and triethylene glycol, with acetyl ketene, generated from 2,2,6-trimethyl-4H-1,3-dioxin-4-one produced acetoacetanilide- containing podands. 2,2,6-Trimethyl-4H-1,3-dioxin-4-one reacted with aminoaryl-substituted podands containing a short polyether chain (1-2 atoms) in toluene medium without catalyst. Acetoacetanilide- containing podands with longer polyether chains could be obtained by using triethylamine or acetic acid as catalyst. Acetoacetanilide-containing podands were used in the Biginelli reaction as СН-active components.


Chemistry of Heterocyclic Compounds | 2013

2-Azido-5-nitropyrimidine: Synthesis, Molecular Structure, and Reactions with N-, O-, and S-Nucleophiles

Evgeny B. Gorbunov; R. K. Novikova; P. V. Plekhanov; P. A. Slepukhin; G. L. Rusinov; V. L. Rusinov; V. N. Charushin; O. N. Chupakhin

We describe the synthesis of 2-azido-5-nitropyrimidine and its azido-tetrazole tautomerism in various solvents and in the crystalline state. It was established that on interacting with N-nucleophiles the attack occurred at the C-2 carbon atom. The O- and S-nucleophiles attacked C-4 position of pyrimidine ring, resulting in tetrazole ring closure.


Chemistry of Heterocyclic Compounds | 1987

Nitroazines. 7. Alkylation of 6-nitro-7-oxo-4,7-dihydroazolo[5,1-c][1,2,4]-triazines and identification of the products

E. N. Ulomskii; V. L. Rusinov; O. N. Chupakhin; G. L. Rusinov; A. I. Chernyshev; G. G. Aleksandrov

Reaction of 6-nitro-7-oxo-4,7-dihydroazolo[5,1-c][1,2,4]triazines with methyl iodide or dimethyl sulfate affords the N-methyl derivatives, no O-alkylation products being found. The effect of the alkylating agent, solvent, and the azole moiety on the course of the reaction has been examined.


Russian Chemical Bulletin | 2014

Synthesis, photochemical and luminescent properties of (E)-2-(2-hydroxyarylethylene)-3-phenylquinazolin-4(3H)-ones

I. G. Ovchinnikova; G. A. Kim; E. G. Matochkina; M. I. Kodess; N. V. Barykin; O. S. El’tsov; E. V. Nosova; G. L. Rusinov; V. N. Charushin

Photoinduced transformations of 2-styrylquinazolinones in solutions were studied using absorption and NMR spectroscopy methods. A possibility of control of the photochemical isomerization rate of quinazolinone 2-(hydroxyaryl)ethenyl derivatives by changing the pH of the medium was demonstrated. The bases and the solvent nature also affect the luminescence intensity of solutions of these compounds in the wavelength range of 550—650 nm. The differences in the steric organization of the ortho-hydroxystyryldiazinone system in crystals and in solutions related to the turn of the aryl group were found. Their influence on the competing processes of luminescence and photochemical transformation of the ethylene fragment were shown. The fact of reversible photo/thermal E-Z-isomerization was established for (E)-2-(2-hydroxystyryl)-3-phenylquinazolin-4(3H)-one.

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V. N. Charushin

Russian Academy of Sciences

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P. A. Slepukhin

Russian Academy of Sciences

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O. V. Fedorova

Russian Academy of Sciences

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O. N. Chupakhin

Russian Academy of Sciences

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R. I. Ishmetova

Russian Academy of Sciences

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Egor V. Verbitskiy

Russian Academy of Sciences

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I. G. Ovchinnikova

Russian Academy of Sciences

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S. G. Tolshchina

Russian Academy of Sciences

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N. K. Ignatenko

Russian Academy of Sciences

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M. I. Kodess

Russian Academy of Sciences

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