P. A. Slepukhin
Russian Academy of Sciences
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Featured researches published by P. A. Slepukhin.
Russian Journal of Organic Chemistry | 2007
M. V. Pryadeina; Ya. V. Burgart; V. I. Saloutin; P. A. Slepukhin; Olga N. Kazheva; G. V. Shilov; O. A. D’yachenko; O. N. Chupakhin
Condensation of ethyl 3-polyfluoroalkyl-3-oxopropionates with excess triethyl orthoformate gave ethyl 3-polyfluoroalkyl-2-ethoxymethylidene-3-oxopropionates which reacted with primary aliphatic, aromatic, and heterocyclic amines to form ethyl 2-alkyl(aryl, hetaryl)aminomethylidene-3-polyfluoroalkyl-3-oxopropionates. According to the X-ray diffraction and IR data, the latter exist in the crystalline state as the corresponding E isomers, while in solution (NMR data), as mixtures of Z and E isomers. Condensation of ethyl 2-ethoxymethylidene-3-oxopropionates with secondary heterocyclic amines (morpholine and pyrrolidine) led to the formation of 2-morpholino(pyrrolidin-1-yl)methylidene-3-fluoroalkyl-3-oxopropionates which were shown to exist as Z isomers both in the crystalline state and in solution.
Chemistry of Heterocyclic Compounds | 2012
Igor S. Kovalev; Dmitry S. Kopchuk; Grigory V. Zyryanov; P. A. Slepukhin; V. L. Rusinov; O. N. Chupakhin
Published examples of the polynuclear fused heterocyclic systems production by cycloaddition reactions involving aryne intermediates generated in situ are reviewed.
Russian Journal of Organic Chemistry | 2011
T. V. Trashakhova; E. V. Nosova; M. S. Valova; P. A. Slepukhin; G. N. Lipunova; V. N. Charushin
Abstracttrans-2-Styryl-substituted 3H-, 3-phenyl-, and 3-naphthylquinazolin-4-ones and their 6,7-difluoro derivatives were synthesized by condensation of appropriate 2-methylquinazolin-4-ones with aromatic aldehydes or by the transformation of the heterocycle of 2-methyl-3,1-benzoxazin-4-one under the action of benzylidenephenylamines.
Russian Journal of Organic Chemistry | 2012
E. S. Izmest’ev; D. V. Sudarikov; S. A. Rubtsova; P. A. Slepukhin; A. V. Kuchin
Asymmetric syntheses were performed of neomenthanesulfinamide in the yield of 60% and de 74%, of neomenthanesulfinaldimines and N-substituted neomenthanesulfinamides in 22–80 and 40–90% yields respectively.
Russian Chemical Reviews | 2015
A. V. Pestov; P. A. Slepukhin; V. N. Charushin
A comparative analysis of the structures of copper(II) and nickel(II) chelate complexes with N-substituted 2-aminoethanols, 3-aminopropan-1-ols, glycines and -alanines is performed. It is shown that tetradentate ligands based on 3-aminopropan-1-ol and -alanine, sterically hindered 2-aminoethanol derivatives and tridentate enamino ketone derivatives tend to form oligonuclear copper(II) and nickel(II) complexes. Glycine derivatives do not provide the formation of oligonuclear copper(II) and nickel(II) complexes. The magnetic properties of a number of polynuclear complexes are compared.The bibliography includes 182 references.
Journal of Structural Chemistry | 2014
E. V. Bartashevich; Irina D. Yushina; E. A. Vershinina; P. A. Slepukhin; Dimitri G. Kim
Iodocyclization products of 2-allylthioquinoline are obtained in the form of polyiodides with different stoichiometric compositions. X-ray crystallography data are analyzed for two different crystal structures of 1-iodomethyl-1,2-dihydro[1,3]thiazolo[3,2-a]quinolinium polyiodides: triiodide C12H11INS+I3− and complex polyiodide 2(C12H11INS+I3−)·I2. A comparison is made of the nonbonding interactions of dihydrothiazoloquinolinium with atoms of the triiodide anion and complex polyiodide to show the crystal structure features attributed to the participation of molecular iodine.
Russian Journal of Organic Chemistry | 2008
G. N. Lipunova; E. V. Nosova; A. A. Laeva; T. V. Trashakhova; P. A. Slepukhin; V. N. Charushin
Proceeding from (tetrafluorobenzoyl)thioureas fluorine-containing derivatives were synthesized of 1-aryl-2-ethylthioquinazolin-4-one, [1,3]benzothiazin-4-one, and also of thiazolidine and 1H-1,2,4-triazole.
Russian Chemical Bulletin | 2012
E. F. Khmara; D. L. Chizhov; A. A. Sidorov; G. G. Aleksandrov; P. A. Slepukhin; M. A. Kiskin; K. L. Tokarev; V. I. Filyakova; G. L. Rusinov; I. V. Smolyaninov; A. S. Bogomyakov; D. V. Starichenko; Yu. N. Shvachko; A. V. Korolev; I. L. Eremenko; V. N. Charushin
Abstract2,6-Bis(5-trifluoromethylpyrazol-3-yl)pyridine (H2L) and its mono-, tri-, and tetranuclear NiII complexes were synthesized for the first time. All the obtained compounds were characterized by single-crystal X-ray diffraction analysis. In the complexes, 2,6-bis(5-trifluoromethylpyrazol-3-yl)pyridine exists in the neutral and dianionic forms and exhibits different coordination modes (κ3-, μ2-κ3:κ1-, and μ3-κ3:κ1:κ1). The electrochemical and magnetic properties of all compounds were studied. The tetranuclear NiII complex with the L2− dianion is reduced in two sequential reversible one-electron steps.
Russian Journal of Organic Chemistry | 2009
T. I. Filyakova; A. Ya. Zapevalov; M. I. Kodess; P. A. Slepukhin; V. I. Saloutin
Perfluoro-3,4-epoxyoxolane and 3,4-epoxy-2-trifluoromethylpentafluorooxolane readily reacted with difunctional nucleophiles via opening of the oxirane ring and subsequent heterocyclization. Their reactions with thiourea and o-phenylenediamine gave new fluorine-containing fused heterocyclic compounds, 2-amino-3a-hydroxy-4,4,6,6,6a-pentafluoro-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]thiazole and 1,1,3,3-tetrafluoro- and 1-trifluoromethyl-1,3,3-trifluoro-1,3-dihydrofuro[3,4-b]quinoxalines, respectively. The molecular and crystalline structures of the products were determined by X-ray analysis.
Chemistry of Natural Compounds | 2014
A. V. Pereslavtseva; I. A. Tolmacheva; P. A. Slepukhin; O. S. El’tsov; I. I. Kucherov; V. F. Eremin; V. V. Grishko
A-seco-triterpenoids with a methylketone group were synthesized from epimeric 3-hydroxy-3-methyl-1-cyano-2,3-seco-triterpenoids of the lupane and 19β,28-epoxy-18αH-oleanane types, which were formed by a Grignard reaction. The resulting methylketones underwent under base-catalysis conditions an intramolecular cyclization to form A-pentacyclic β-substituted alkenenitriles. The synthesized compounds included 3-methyl-1-cyano-19β,28-epoxy-2,3-seco-2-nor-18αH-olean-3-one and methyl 3-methyl-1-cyano-2-norlup-1(3),20(29)-dien-28-oate, which inhibited in vitro reproduction of human immunodeficiency virus type 1.