G. Lakhoua

DRESS Syndrome Following Levofloxacin Exposure With Positive Patch-test

Drug rash with eosinophilia and systemic symptoms (DRESS syndrome) in a severe cutaneous drug reaction, which can be life threatening. Levofloxacin has not been reported in literature as a causative drug. We are presenting an exceptional case of levofloxacin-induced DRESS without eosinophilia and with positive patch-tests to levofloxacin.

Probable disseminated BCG infection in a 10-month-old child after BCG vaccination

The disseminated BCG infection is a rare and serious complication of bacillus Calmette-Guerin (BCG) vaccine. We report a case of probable disseminated BCG infection in a 10-month-old child who had been vaccinated by BCG vaccine at birth. No incident was noted on the first days of vaccination. At the age of 40 days, she developed left supra clavicular and axillar abcessed lymph nodes. She was treated by surgical flattening of the lymph adenopathy. The same lymph node recurred at the age of 6 months and was treated with surgery. Few weeks after the second episode, cutaneous ulcerative lesions appeared. Cutaneous biopsy was performed and showed lesions compatible with tuberculosis. X-rays showed osteolysis of P1 of the middle finger in the left hand. She was treated by anti-tuberculosis antibiotics.

Lichen Associated with Metformin

We report an exceptional case of bullous lichen induced by metformin in a patient with diabetes mellitus.

Multiple Drug Intolerance Syndrome in an Epileptic Woman

The term multiple drug intolerance syndrome (MDIS) is used for patients who express adverse drug reactions to three or more drugs without a known immunological mechanism [1]. It is a distinct clinical entity, different from cross-reactivity and flare-up reactions. The symptoms can range from a benign rash to life threatening syndromes like drug reaction with eosinophilia and systemic symptoms (DRESS syndrome). We report a case of an epileptic woman who presented MDIS. The case was notified to the Tunisian pharmacovigilance center on February 20th 2014.

Bullous Eruption Associated With Dihydropyridines With Cross Reactivity.

The spectrum of cutaneous eruptions associated with dihydropyridines is extensive, varying from exanthemas to severe adverse events. We report a case of bullous eruption, one month after starting nicardipine and lercanidipine. The same symptoms recurred few days after taking nitrendipine.

Hydroxychloroquine-induced acute generalized exanthematous pustulosis with positive patch-testing.

Acute generalized exanthematous pustulosis (AGEP) is a severe cutaneous adverse reaction, mostly induced by drugs. Hydroxychloroquine have been rarely reported in literature as a causative drug of this reaction. We report a case of AGEP induced by hydroxychloroquine with systemic involvement and confirmed by positive patch testing.