Gabriella Rapini
National Health Service
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Featured researches published by Gabriella Rapini.
International Journal of Molecular Sciences | 2015
Domenico De Berardis; Michele Fornaro; Nicola Serroni; Daniela Campanella; Gabriella Rapini; Luigi Olivieri; Venkataramanujam Srinivasan; Felice Iasevoli; Carmine Tomasetti; Andrea de Bartolomeis; Alessandro Valchera; Giampaolo Perna; Monica Mazza; Marco Di Nicola; Giovanni Martinotti; Massimo Di Giannantonio
Agomelatine, a melatonergic antidepressant with a rapid onset of action, is one of the most recent drugs in the antidepressant category. Agomelatine’s antidepressant actions are attributed to its sleep-promoting and chronobiotic actions mediated by MT1 and MT2 receptors present in the suprachiasmatic nucleus, as well as to its effects on the blockade of 5-HT2c receptors. Blockade of 5-HT2c receptors causes release of both noradrenaline and dopamine at the fronto-cortical dopaminergic and noradrenergic pathways. The combined actions of agomelatine on MT1/MT2 and 5-HT2c receptors facilitate the resynchronization of altered circadian rhythms and abnormal sleep patterns. Agomelatine appeared to be effective in treating major depression. Moreover, evidence exists that points out a possible efficacy of such drug in the treatment of bipolar depression, anxiety disorders, alcohol dependence, migraines etc. Thus, the aim of this narrative review was to elucidate current evidences on the role of agomelatine in disorders other than major depression.
Archives of Suicide Research | 2017
Domenico De Berardis; Nicola Serroni; Daniela Campanella; Stefano Marini; Gabriella Rapini; Alessandro Valchera; Felice Iasevoli; Monica Mazza; Michele Fornaro; Giampaolo Perna; Giuseppe Di Iorio; Giovanni Martinotti; Massimo Di Giannantonio
The aim of the present study was to investigate the relationships between alexithymia, suicide ideation, C-Reactive Protein (CRP), and serum lipid levels in adult outpatients with a DSM-IV diagnosis of Generalized Anxiety Disorder (GAD). Seventy consecutive patients with GAD were recruited and evaluated. Measures were the Hamilton Anxiety Scale, the Toronto Alexithymia Scale (TAS–20), the Scale of Suicide Ideation (SSI), and the Montgomery Åsberg Depression Rating Scale (MADRS). All patients were assessed for: CRP, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), triglyceridaemia (TG), and very-low-density lipoprotein cholesterol (VLDL-C). TC/HDL-C and LDL-C/HDL-C ratios were also evaluated. Alexithymic patients showed higher scores on almost all rating scales and altered serum CRP and lipid levels vs. non-alexithymics. In the hierarchical regression model, the presence of higher MADRS scores together with higher scores at the Difficulty in Identifying Feelings dimension of TAS-20 were associated with higher rates of suicide ideation. Although alexithymic subjects with GAD may show a CRP and cholesterol dysregulation, this latter seems independent on increased suicide ideation, rather to Difficulty in Identifying Feelings, and subthreshold depressive symptoms. Study limitations and future research implications are discussed.
Revista Brasileira de Psiquiatria | 2014
Domenico De Berardis; Nicola Serroni; Stefano Marini; Gabriella Rapini; Alessandro Carano; Alessandro Valchera; Felice Iasevoli; Monica Mazza; Maria Salvina Signorelli; Eugenio Aguglia; Giampaolo Perna; Giovanni Martinotti; Paola Annunziata Varasano; Gabriella Lucidi Pressanti; Massimo Di Giannantonio
OBJECTIVE As obsessive-compulsive disorder (OCD) is a relatively common psychiatric disorder with a significant suicide risk, the individuation of potential biomarkers of suicidality, such as cholesterol levels, may enable recognition of at-risk subjects. Therefore, the aims of this study were to: 1) evaluate potential differences in clinical and laboratory parameters between patients with and without alexithymia and compare them with healthy controls; and 2) investigate which clinical and laboratory variables were associated with suicidal ideation. METHODS 79 drug-naïve adult outpatients with a DSM-IV diagnosis of OCD were recruited. Alexithymia was measured with the 20-item Toronto Alexithymia Scale (TAS-20), suicidal ideation was assessed with the Scale for Suicide Ideation, and depressive symptoms were evaluated with the Montgomery-Åsberg Depression Rating Scale (MADRS). Serum lipid levels of 40 healthy controls were also evaluated. RESULTS Alexithymic patients had altered serum lipid levels in comparison with non-alexithymics and healthy controls. Using a linear regression model, the presence of symmetry/ordering obsessions and compulsions, lower HDL-C levels, and difficulty in identifying feelings dimension of the TAS-20 were associated with higher suicidal ideation. CONCLUSIONS Alexithymic individuals with OCD may exhibit dysregulation of the cholesterol balance, which in turn may be linked to suicidal ideation. Further prospective studies are required to elucidate this potential association.
Comprehensive Psychiatry | 2015
Domenico De Berardis; Nicola Serroni; Daniela Campanella; Gabriella Rapini; Luigi Olivieri; Barbara Feliziani; Alessandro Carano; Alessandro Valchera; Felice Iasevoli; Carmine Tomasetti; Monica Mazza; Michele Fornaro; Giampaolo Perna; Marco Di Nicola; Giovanni Martinotti; Massimo Di Giannantonio
AIMS Obsessive-compulsive disorder (OCD) is psychiatric disorder with a significant suicide risk, and the presence of alexithymia may increase this risk. As several studies attribute an important role, in OCD, to responsibility, the aims of this study were to evaluate possible clinical differences between patients positive or not for alexithymia concerning disorder severity, responsibility attitudes and suicide ideation and investigate which variables were associated with increased suicide ideation. METHODS 104 adult outpatients with OCD were recruited. Alexithymia was measured with Toronto Alexithymia Scale (TAS-20), attitude about responsibility was tested with Responsibility Attitude Scale (RAS), suicide ideation was assessed with Scale of Suicide Ideation (SSI) and depressive symptoms were evaluated with Montgomery Åsberg Depression Rating Scale (MADRS). Score of item #11 on the Y-BOCS was considered as a measure of insight. RESULTS Patients positive for alexithymia showed higher responsibility attitudes and more severe suicide ideation. In a blockwise regression model, the presence of lower insight, higher RAS scores and difficulty in identifying feelings dimension of TAS-20 were associated with higher SSI scores. CONCLUSIONS OCD patients with alexithymia may show higher disorder severity, lower insight and inflated responsibility, all related to suicide ideation, independently from depressive symptoms. Implications were discussed and study limitations considered and reported.
The Scientific World Journal | 2013
Domenico De Berardis; Stefano Marini; Nicola Serroni; Gabriella Rapini; Felice Iasevoli; Alessandro Valchera; Maria Salvina Signorelli; Eugenio Aguglia; Giampaolo Perna; Anatolia Salone; Giuseppe Di Iorio; Giovanni Martinotti; Massimo Di Giannantonio
We investigated the efficacy of S-Adenosyl-L-Methionine (SAMe) augmentation in patients with treatment-resistant depressive disorder (TRD). Thirty-three outpatients with major depressive episode who failed to respond to at least 8 weeks of treatment with two adequate and stable doses of antidepressants were treated openly with fixed dose of SAMe (800 mg) for 8 weeks, added to existing medication. The primary outcome measure was the change from baseline in total score on Hamilton Rating Scale for Depression (HAM-D). The Clinical Global Impression of Improvement (CGI-I) was rated at the endpoint. Patients with a reduction of 50% or more on HAM-D total score and a CGI-I score of 1 or 2 at endpoint were considered responders; remission was defined as a HAM-D score ≤7. Secondary outcome measures included the Snaith-Hamilton Pleasure Scale (SHAPS) and the Sheehan Disability Scale (SDS). At 8 weeks, a significant decrease in HAM-D score was observed with response achieved by 60% of the patients and remission by 36%. Also a statistically significant reduction in SHAPS and SDS was observed. Our findings indicate that SAMe augmentation may be effective and well tolerated in stage II TRD. However, limitations of the present study must be considered and further placebo-controlled trials are needed.
Case reports in psychiatry | 2013
Domenico De Berardis; Nicola Serroni; Stefano Marini; Gabriella Rapini; Alessandro Valchera; Michele Fornaro; Monica Mazza; Felice Iasevoli; Giovanni Martinotti; Massimo Di Giannantonio
Delusional parasitosis is characterized by the false idea that own body is infested by invisible mites, insects, or other parasites. This case report describes a 24-year-old woman with delusional parasitosis who was treated with ziprasidone monotherapy (120 mg/day) with a complete remission of delusion and followed for one year without symptom recurrences. These findings, although preliminary, indicate that further investigation of ziprasidone monotherapy for the treatment of delusional parasitosis is warranted in further trials.
Therapeutic advances in drug safety | 2018
Domenico De Berardis; Gabriella Rapini; Luigi Olivieri; Domenico Di Nicola; Carmine Tomasetti; Alessandro Valchera; Michele Fornaro; Fabio Di Fabio; Giampaolo Perna; Marco Di Nicola; Gianluca Serafini; Alessandro Carano; Maurizio Pompili; Federica Vellante; Laura Orsolini; Giovanni Martinotti; Massimo Di Giannantonio
Clozapine, a dibenzodiazepine developed in 1961, is a multireceptorial atypical antipsychotic approved for the treatment of resistant schizophrenia. Since its introduction, it has remained the drug of choice in treatment-resistant schizophrenia, despite a wide range of adverse effects, as it is a very effective drug in everyday clinical practice. However, clozapine is not considered as a top-of-the-line treatment because it may often be difficult for some patients to tolerate as some adverse effects can be particularly bothersome (i.e. sedation, weight gain, sialorrhea etc.) and it has some other potentially dangerous and life-threatening side effects (i.e. myocarditis, seizures, agranulocytosis or granulocytopenia, gastrointestinal hypomotility etc.). As poor treatment adherence in patients with resistant schizophrenia may increase the risk of a psychotic relapse, which may further lead to impaired social and cognitive functioning, psychiatric hospitalizations and increased treatment costs, clozapine adverse effects are a common reason for discontinuing this medication. Therefore, every effort should be made to monitor and minimize these adverse effects in order to improve their early detection and management. The aim of this paper is to briefly summarize and provide an update on major clozapine adverse effects, especially focusing on those that are severe and potentially life threatening, even if most of the latter are relatively uncommon.
Journal of Clinical Psychopharmacology | 2017
Domenico De Berardis; Luigi Olivieri; Francesco Nappi; Gabriella Rapini; Federica Vellante; Ilaria Matarazzo; Nicola Serroni; Massimo Di Giannantonio
To the EditorsObsessive-compulsive disorder (OCD) is a chronic and disabling disorder with a fluctuating course, and it is characterized by obsessions or compulsions that cause severe distress and interfere with the patients functioning.1 The role of serotonin (5-HT) systems in OCD has been sup
Rivista Di Psichiatria | 2011
Marasco; De Berardis D; Nicola Serroni; Daniela Campanella; T. Acciavatti; M Caltabiano; Luigi Olivieri; Gabriella Rapini; A Cicconetti; Alessandro Carano; La Rovere R; Di Iorio G; Francesco Saverio Moschetta; Di Giannantonio M
Rivista Di Psichiatria | 2015
De Berardis D; Maurizio Brucchi; Nicola Serroni; Gabriella Rapini; Daniela Campanella; Federica Vellante; Alessandro Valchera; Michele Fornaro; Felice Iasevoli; Monica Mazza; Lucidi G; G. Martinotti; Di Giannantonio M