Gandhi K. Kar

Synthesis of a New Family of Receptors having Dibenz[c,h]acridine as Spacers and their Binding Affinity with Urea

Abstract New molecular receptors with a dibenz[ c , h ]acridine as spacer and having functionality complementary to urea have been developed.

Molecular recognition: studies on the synthesis of some bis thiophene carboxamide derivatives as ditopic receptors for long chain dicarboxylic acids

Abstract New molecular receptors 6, 7 and 8 with diphenyl ether/diphenyl sulphide as spacer having functional groups complementary to long chain dicarboxylic acids have been developed. Binding studies with different dicarboxylic acids showed high association constants with the receptor 6.

Structurally designed novel furogamma lactams as inhibitors for bacterial propagations

Some novel furogamma lactams have been synthesised by one step condensation of arylaminomalonates with substituted furyl acryloyl chlorides. The annulation of substituted monocyclic gammalactams followed by cyclization produced novel tricyclic furogamma lactams. Some of these furogammalactams are found to exhibit Gram-positive and Gram-negative antibacterial activity at very high concentrations.

Regioselective cyclisation of anil derivatives-A short : Synthesis of dibenzacridines

Abstract Dibenzacridines have been synthesised in almost quantitative yields by regioselective thermal cyclisation of anil hydrochlorides followed by dehydrogenation.

Synthetic studies towards furosesquiterpenes: Construction of linearly-fused AB trans- and AB cis-furo[3,2-b]-and furo[2,3-b] decalins

Abstract Linearly fused furo[2,3-b]- and furo[3,2-b] decalin systems with cis trans ring junctions are present in several furosesquiterpenes obtained from marine sponges. A short and efficient synthesis of this ring system is described starting from Hagemans ester (1). The method has been extended for the synthesis of compound 8 and 14 via the diketones 5,6 and 12 respectively.

Chemoselective method for the synthesis of 4-allyl-4-hydroxycyclohexa-2,5-dienone derivatives from 1,4-quinones by an indium-mediated allylation protocol

Allyl indium halide on reaction with 1,4-quinones produced 4-allyl-4-hydroxycyclohexa-2,5-dienone derivatives. Unsymmetrical quinones show high chemoselectivity in addition of allyl indium halide reagent to the carbonyl group.

STUDIES ON POLYCYCLIC AZAARENES - 1. SYNTHESIS OF ACENAPHTHO(1,2-B)QUINOLINES

Abstract A simple synthesis of acenaphthoquinolines by thermal cyclization of anils is described.

Studies on furoterpenes: Stereoselective total synthesis of (±)-Ambliol-A and Dendrolasin

Abstract (±)-Ambliol-A ( 1 ) is totally synthesised with high stereoselectivity starting from α-ionone and [3-(3′-furyl)propyl]triphenylphosphonium bromide ( 3 ). In another attempt utilising 3 with the commercially available ketone 11 the total synthesis of Dendrolasin ( 12 ) has also been achieved.

A ‘One Pot’ Synthesis of Acenaphtho[1,2-b]Benzo[f] and Acenaphtho[1,2-b]Benzo[h]Quinolines

Abstract A short, simple and high yielding ‘one pot’ synthesis of two acenaptho[1,2-b]benzo-quinolines have been described which involved highly regioselective thermal cyclization of enaminoimine hydrochlorides from 2-chloro-1-formylacenaphthylene and ½-naphthylamine.

A Convenient Synthesis of Tricyclic Gamma-Lactams, Simulating B-C-D Rings of Azasteroids Via Michael Addition Reaction

Abstract Cinnamolychloride on treatment with arylaminomalonates produced the δ-lactam diester derivatives. Highly stereoselective hydrolysis of the diester, produced the trans acid, which on homologation by Arndt-Eisterts method followed by PPA cyclization generated the tricyclic δ-lactam derivatives simulating B-C-D ring of many azasteroids in good overall yield.