Gayle K. Matsumoto

Diarrhetic shellfish toxins

Abstract As the causative agents of a new type of shellfish poisoning, named diarrhetic shellfish poisoning, okadaic acid, 35(S)-methylokadaic acid, 7-O-acyl derivatives of 35(S)-methylokadaic acid, two novel polyether lactones named pectenotoxin-1 and -2 have been isolated and had their structures determined. Three pectenotoxin analogues were also present. In addition to the previously identified Dinophysis fortii, D. acuminata was newly suggested as a source of toxins.

Isolation and structure of rebeccamycin ― a new antitumor antibiotic from Nocardia aerocoligenes

The isolation and structure elucidation of rebeccamycin 1, a new antitumor agent from , is described. The NMR spectra of 1 and its peracetate 2 are discussed.

The structure of leptosphaerin

Abstract The structure and relative configuration of leptosphaerin, a metabolite of the marine ascomycete Leptosphaeria oraemaris (Linder) was established as 2 by spectral analysis and elimination of an alternative structure 1 through synthesis.

Two new xenicin diterpenoids from the octocoral Anthelia edmondsoni

Abstract From the soft coral Anthelia edmondsoni two new diterpenoids, waixenicin-A ( 1 ) and -B ( 2 ) have been Isolated. Their structures were elucidated by1H and13C NMR analysis and the relative stereochemistry was determined by x-ray diffraction of crystalline waixenicin-B ( 2 ).

Structure of the diterpene portion of a novel base from the sponge Agelas mauritiana

Abstract The structure of purino-diterpene 2, derived from an unknown antimicrobial metabolise of Agelas mauritiana, was determined by X-ray analysis.