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Publication
Featured researches published by Ge Xu.
Journal of Medicinal Chemistry | 2014
Ge Xu; Binhua Lv; Jacques Y. Roberge; Baihua Xu; Jiyan Du; Jiajia Dong; Yuanwei Chen; Kun Peng; Lili Zhang; Xinxing Tang; Yan Feng; Min Xu; Wei Fu; Wenbin Zhang; Liangcheng Zhu; Zhongping Deng; Zelin Sheng; Ajith Welihinda; Xun Sun
SGLT2 inhibitors deuterated at sites susceptible to oxidative metabolism were found to have a slightly longer tmax and half-life (t1/2), dose-dependent increase in urinary glucose excretion (UGE) in rats, and slightly superior effects on UGE in dogs while retaining similar in vitro inhibitory activities against hSGLT2. In particular, deuterated compound 41 has the potential to be a robust long-acting antidiabetic agent.
Bioorganic & Medicinal Chemistry | 2010
Baihua Xu; Yan Feng; Binhua Lv; Ge Xu; Lili Zhang; Jiyan Du; Kun Peng; Min Xu; Jiajia Dong; Wenbin Zhang; Ting Zhang; Liangcheng Zhu; Haifeng Ding; Zelin Sheng; Ajith Welihinda; Brian Seed; Yuanwei Chen
A series of 2-substituted C-aryl glucosides have been synthesized and evaluated for inhibition of hSGLT1 and hSGLT2. Introduction of an appropriate ortho substituent at the proximal phenyl ring adjacent to the glycosidic bond was found to improve SGLT2 inhibitory activity and dramatically increase selectivity for hSGLT2 over hSGLT1. Selected compounds were investigated for in vivo efficacy.
Archive | 2008
Yuanwei Chen; Yan Feng; Baihua Xu; Binhua Lv; Brian Seed; Michael J. Hadd; Huawei Cheng; Zelin Sheng; Min Xu; Congna Wang; Jiyan Du; Lili Zhang; Ge Xu; Yuelin Wu
Bioorganic & Medicinal Chemistry Letters | 2009
Binhua Lv; Baihua Xu; Yan Feng; Kun Peng; Ge Xu; Jiyan Du; Lili Zhang; Wenbin Zhang; Ting Zhang; Liangcheng Zhu; Haifeng Ding; Zelin Sheng; Ajith Welihinda; Brian Seed; Yuanwei Chen
Bioorganic & Medicinal Chemistry Letters | 2009
Baihua Xu; Binhua Lv; Yan Feng; Ge Xu; Jiyan Du; Ajith Welihinda; Zelin Sheng; Brian Seed; Yuanwei Chen
Archive | 2009
Brian Seed; Binhua Lv; Jacques Y. Roberge; Yuanwei Chen; Kun Peng; Jiajia Dong; Baihua Xu; Jiyan Du; Lili Zhang; Xinxing Tang; Ge Xu; Yan Feng; Min Xu
Archive | 2008
Yuanwei Chen; Kun Peng; Lili Zhang; Binhua Lv; Baihua Xu; Jiajia Dong; Jiyan Du; Yan Feng; Ge Xu; Vasanthakumar Rajappan; Brian Seed
Archive | 2013
Baihua Xu; Binhua Lv; Ge Xu; Brian Seed; Jacques Y. Roberge
Archive | 2013
Baihua Xu; Binhua Lv; Ge Xu; Brian Seed; Jacques Y. Roberge
Archive | 2011
Mengzhuang Cai; Qian Liu; Ge Xu; Binhua Lv; Brian Seed; Jacques Y. Roberge