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Dive into the research topics where Gelson Perin is active.

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Featured researches published by Gelson Perin.


Chemical Reviews | 2009

Synthesis of Vinyl Selenides

Gelson Perin; Eder J. Lenardão; Raquel G. Jacob; Rodrigo B. Panatieri

The versatility and utility of vinyl chalcogenides in organic synthesis is well documented through the publication of a number of review articles1 and books.2 The development of new methods for the preparation and applicability of vinyl sulfides,3a-c sulfones,3d and tellurides4 was recently revised. * Corresponding author. Phone/fax: +55 53 3275 7533. E-mail: [email protected]. Chem. Rev. 2009, 109, 1277–1301 1277


Green Chemistry | 2012

Glycerol as a recyclable solvent for copper-catalyzed cross-coupling reactions of diaryl diselenides with aryl boronic acids

Vanessa G. Ricordi; Camilo S. Freitas; Gelson Perin; Eder J. Lenardão; Raquel G. Jacob; Lucielli Savegnago; Diego Alves

We describe herein the use of glycerol as the solvent in the copper-catalyzed cross-coupling reaction of diaryl diselenides with arylboronic acids using CuI and DMSO as additive. This cross-coupling reaction was performed with diaryl diselenides and arylboronic acids bearing electron-withdrawing and electron-donating groups, affording the corresponding diaryl selenides in good to excellent yields. The glycerol–CuI mixture can be directly reused for further cross-coupling reactions.


Food and Chemical Toxicology | 2012

Essential oil of the leaves of Eugenia uniflora L.: Antioxidant and antimicrobial properties

Francine Novack Victoria; Eder J. Lenardão; Lucielli Savegnago; Gelson Perin; Raquel G. Jacob; Diego Alves; Wladimir Padilha da Silva; Amanda de Souza da Motta; Patrícia da Silva Nascente

Essential oil (EO) of the leaves of Eugenia uniflora L. (Brazilian cherry tree) was evaluated for its antioxidant, antibacterial and antifungal properties. The acute toxicity of the EO administered by oral route was also evaluated in mice. The EO exhibited antioxidant activity in the DPPH, ABTS and FRAP assays and reduced lipid peroxidation in the kidney of mice. The EO also showed antimicrobial activity against two important pathogenic bacteria, Staphylococcus aureus and Listeria monocytogenes, and against two fungi of the Candida species, C. lipolytica and C. guilliermondii. Acute administration of the EO by the oral route did not cause lethality or toxicological effects in mice. These findings suggest that the EO of the leaves of E. uniflora may have the potential for use in the pharmaceutical industry.


Journal of the Brazilian Chemical Society | 2009

Green Michael addition of thiols to electron deficient alkenes using KF/alumina and recyclable solvent or solvent-free conditions

Eder J. Lenardão; Danusia O. Trecha; Patrícia C. Ferreira; Raquel G. Jacob; Gelson Perin

A general, clean and easy method for the conjugated addition of thiols to citral promoted by KF/Al2O3 under solvent-free or using glycerin as recyclable solvent at room temperature is described. It was found that the solvent-free protocol is applicable to the direct reaction of thiophenol with the essential oil of lemon grass (Cymbopogon citratus) to afford directly 3,7-dimethyl-3-(phenylthio)oct-6-enal, a potential bactericide agent. The method was extended to other electron-poor alkenes with excellent results. For the solvent-free protocol, the use of microwave irradiation facilitated the procedure and accelerates the reaction. The catalytic system and glycerin can be reused up to three times without previous treatment with comparable activity.


Tetrahedron Letters | 2003

Green synthesis of (−)-isopulegol from (+)-citronellal: application to essential oil of citronella

Raquel G. Jacob; Gelson Perin; Leticia N. Loi; Claudia S. Pinno; Eder J. Lenardão

A simple green and efficient method has been developed for the synthesis of (−)-isopulegol from (+)-citronellal in the presence of a solid supported catalyst (SiO2/ZnCl2), under solvent-free conditions and MW irradiation. It was also found that the same technology is applicable to the direct preparation of (−)-isopulegol from the essential oil of citronella (Cymbopogon nardus, growing in southern Brazil) in excellent yield.


Tetrahedron Letters | 2003

Clean and atom-economic synthesis of octahydroacridines: application to essential oil of citronella

Raquel G. Jacob; Gelson Perin; Giancarlo V. Botteselle; Eder J. Lenardão

Abstract A green and efficient method for the synthesis of octahydroacridine (OHA) has been developed by a simple one-pot hetero-Diels–Alder reaction starting from (+)-citronellal and N -arylamines in the presence of a solid supported catalyst (SiO 2 /ZnCl 2 ), under MW irradiation and without any solvent. The method was used in the direct preparation of OHA from citronella oil in good yield.


Green Chemistry | 2015

Synthesis of bis(indolyl)methanes using ammonium niobium oxalate (ANO) as an efficient and recyclable catalyst

Samuel R. Mendes; Samuel Thurow; Filipe Penteado; Maitê S. da Silva; Rogério A. Gariani; Gelson Perin; Eder J. Lenardão

A green and efficient procedure was developed for the synthesis of bis(indolyl)methanes using ammonium niobium oxalate (ANO) NH4[NbO(C2O4)2(H2O)x]·nH2O as the catalyst and water or glycerol as the solvent. Products were obtained in good to excellent yields under conventional heating (water, 50 °C) or under sonication (glycerol, 110 °C). In the reaction in water, the catalyst was easily reused for further reactions without loss of activity.


Green Chemistry | 2011

Synthesis of diaryl selenides using electrophilic selenium species and nucleophilic boron reagents in ionic liquids

Camilo S. Freitas; Angelita M. Barcellos; Vanessa G. Ricordi; Jesus M. Pena; Gelson Perin; Raquel G. Jacob; Eder J. Lenardão; Diego Alves

We described herein the use of imidazolium ionic liquids [bmim]PF6 and [bmim]BF4 in the selective, metal and catalyst-free synthesis of unsymmetrical diaryl selenides by electrophilic substitution in arylboron reagents with arylselenium halides (Cl and Br) at room temperature. This is a general substitution reaction and it was performed with arylboronic acids or potassium aryltrifluoroborates bearing electron-withdrawing or electron-donating groups, affording the corresponding diaryl selenides in good to excellent yields. The ionic liquid [bmim][PF6] was easily recovered and utilized for further substitution reactions.


Ultrasonics Sonochemistry | 2015

Sonochemistry: An efficient alternative to the synthesis of 3-selanylindoles using CuI as catalyst

Beatriz M. Vieira; Samuel Thurow; Juliana Nunes de Sá Brito; Gelson Perin; Diego Alves; Raquel G. Jacob; Claudio Santi; Eder J. Lenardão

Ultrasonic (US) irradiation was successfully used as an alternative energy source to prepare 3-selanylindoles through the direct selanylation of indoles with diorganyl diselenides using CuI (20 mol%) as catalyst and DMSO as the solvent. By using this US-promoted reaction, eleven 3-organylselanylindoles were prepared selectively and in good yields. A comparative study between the reactions under conventional heating, microwave and ultrasound irradiations was performed, and it was observed advantage in using US over the other heating systems.


Organic Letters | 2015

Room-Temperature Organocatalytic Cycloaddition of Azides with β-Keto Sulfones: Toward Sulfonyl-1,2,3-triazoles.

Maiara T. Saraiva; Gabriel P. Costa; Natália Seus; Ricardo F. Schumacher; Gelson Perin; Márcio W. Paixão; Rafael Luque; Diego Alves

Organocatalytic enamine-azide [3 + 2] cycloadditions between β-keto sulfones and aryl azides can be performed at room temperature in good to excellent yields of products in the presence of catalytic amounts of pyrrolidine (5 mol %). The proposed organocatalytic methodology was found to be applicable to β-keto arylsulfones containing a range of substituents. A wide variety of aryl azides also work. Basically, this constitutes a remarkably efficient protocol for the synthesis of novel 1,2,3-triazole compounds.

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Eder J. Lenardão

Universidade Federal de Pelotas

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Raquel G. Jacob

Universidade Federal de Pelotas

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Diego Alves

Universidade Federal de Pelotas

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Ricardo F. Schumacher

Universidade Federal de Pelotas

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Elton L. Borges

Universidade Federal de Pelotas

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Samuel R. Mendes

Universidade Federal de Santa Maria

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Márcio S. Silva

Universidade Federal do ABC

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Lucielli Savegnago

Universidade Federal de Pelotas

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Samuel Thurow

Universidade Federal de Pelotas

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Angelita M. Barcellos

Universidade Federal de Pelotas

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