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Dive into the research topics where Márcio S. Silva is active.

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Featured researches published by Márcio S. Silva.


Synthetic Communications | 2006

Synthesis of β‐Phenylchalcogeno‐α,β‐unsaturated Ketones via Hydrochalcogenation of Acetylenes using Microwave and Solvent‐Free Conditions

Gelson Perin; Samuel R. Mendes; Márcio S. Silva; Eder J. Lenardão; Raquel G. Jacob; Paulo C. dos Santos

Abstract A simple, clean, and efficient solvent‐free protocol was developed for hydrochalcogenation of 3‐organyl‐3‐butyn‐2‐ones with phenylchalcogenolate (Se, Te, S) anions generated in situ from the respective diphenyl dichalcogenide using alumina‐supported sodium borohydride (Se, Te) or commercially available (S). This efficient and improved method is general and furnishes the (Z)‐β‐phenylchalcogeno‐α,β‐unsaturated ketones in good yield with higher selectivity compared with those that use organic solvent and an inert atmosphere. The use of microwave (MW) irradiation facilitates the procedure and accelerates the reaction.


New Journal of Chemistry | 2016

Synthesis of enantiomerically pure bis(2,2-dimethyl-1,3-dioxolanylmethyl)chalcogenides and dichalcogenides

Elton L. Borges; Thiago J. Peglow; Márcio S. Silva; Caroline Gross Jacoby; Paulo H. Schneider; Eder J. Lenardão; Raquel G. Jacob; Gelson Perin

Herein we describe the reaction between the nucleophilic species of chalcogenium (sulfur, selenium and tellurium) and (R)- and (S)-solketal tosylates to prepare enantiomerically pure bis-1,3-dioxolanylmethyl chalcogenides and dichalcogenides in short reaction times and good yields. Furthermore, the new diselenide 4a was evaluated in the Michael reaction with acrylonitrile, giving (R)-3-[(2,3-dihydroxypropyl)selanyl]propanenitrile 6b after two steps.


Synthetic Communications | 2009

Atom-Economic Synthesis of Functionalized Octahydroacridines from Citronellal or 3-(Phenylthio)-citronellal

Raquel G. Jacob; Márcio S. Silva; Samuel R. Mendes; Elton L. Borges; Eder J. Lenardão; Gelson Perin

Abstract Here we present a simple, solvent-free, one-pot, hetero-Diels–Alder reaction of (R)-citronellal or 3-(phenylthio)-citronellal with arylamines using solid-supported catalyst (SiO2/ZnCl2). This general, efficient, and improved method is selective, affording preferentially new trans-fused 3-(phenylthio)-octahydroacridines (S-OHAs) in good yields. The use of microwave irradiation facilitates the procedure and accelerates the reaction.


New Journal of Chemistry | 2015

Chiral discrimination of β-telluride carboxylic acids by NMR spectroscopy

Márcio S. Silva; Daniel Pietrobom

In this work, the nuclei (1H and 125Te) for NMR spectroscopy and enantiopure compounds as chiral solvent agents (CSAs) and chiral derivatisation agents (CDAs) were evaluated under different conditions. The structure of β-telluride carboxylic acids was also modified to observe the effect on anisochrony.


Synthetic Communications | 2014

Synthesis of β-Aryl-β-sulfanyl Ketones by a Sequential One-Pot Reaction Using KF/Al2O3 in Glycerol

Gelson Perin; Katiúcia Daiane Mesquita; Tainara P. Calheiro; Márcio S. Silva; Eder J. Lenardão; Diego Alves; Raquel G. Jacob

Abstract The title compounds were synthesized by a sequential one-pot reaction of aryl aldehydes, aryl-methyl ketones, and thiols promoted by KF/Al2O3. This methodology affords a large number of β-aryl-β-sulfanyl ketone derivatives from aliphatic and aromatic thiols in good yields and is also applicable for solid substrates. [Supplementary materials are available for this article. Go to the publishers online edition of Synthetic Communications® for the following free supplemental resource(s): Full experimental and spectral details.] GRAPHICAL ABSTRACT


PeerJ | 2018

Ultrasound-promoted synthesis of 2-organoselanyl-naphthalenes using Oxone® in aqueous medium as an oxidizing agent

Gelson Perin; Daniela Rodrigues Araujo; Patrick C. Nobre; Eder J. Lenardão; Raquel G. Jacob; Márcio S. Silva; Juliano A. Roehrs

A green methodology to synthesize 2-organoselanyl-naphthalenes based on the reaction of alkynols with diaryl diselenides is described. The electrophilic species of selenium were generated in situ, by the oxidative cleavage of the Se–Se bond of diaryl diselenides by Oxone® using water as the solvent. The reactions proceeded efficiently under ultrasonic irradiation as an alternative energy source, using a range of alkynols and diorganyl diselenides as starting materials. Through this methodology, the corresponding 2-organoselanyl-naphthalenes were obtained in moderate to good yields (56–94%) and in short reaction times (0.25–2.3 h).


Journal of the Brazilian Chemical Society | 2016

Simplification of Lipase Design in the Enzymatic Kinetic Resolution of Amines by Saturation Transfer Difference NMR

Márcio S. Silva; Daniel Pietrobom

In this work, we demonstrate a nuclear magnetic resonance (NMR) method for racemic amide and lipase interaction as a first-pass design method in the enzymatic kinetic resolution of amines. As a novel adaptation of commonly used protein-ligand screening NMR methodologies, this approach relies upon a lipase-amide interaction wherein the time-consuming is reduced drastically and new insights are produced during the development of biocatalysis reactions.


Arkivoc | 2009

Synthesis of vinyl selenides and tellurides using PEG-400

Eder J. Lenardão; Márcio S. Silva; Maraisa Sachini; Renata G. Lara; Raquel G. Jacob; Gelson Perin


Arkivoc | 2011

Synthesis of vinyl sulfides using glycerol as a recyclable solvent

Eder J. Lenardão; Márcio S. Silva; Renata G. Lara; Júnior M. Marczewski; Maraisa Sachini; Raquel G. Jacob; Diego Alves; Gelson Perin


Tetrahedron Letters | 2016

77Se and 125Te NMR spectroscopy for enantiopurity determination of chalcogen amines

Samuel S. Oliveira; Rodrigo L.O.R. Cunha; Márcio S. Silva

Collaboration


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Gelson Perin

Universidade Federal de Pelotas

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Raquel G. Jacob

Universidade Federal de Pelotas

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Eder J. Lenardão

Universidade Federal de Pelotas

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Diego Alves

Universidade Federal de Pelotas

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Elton L. Borges

Universidade Federal de Pelotas

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Daniel Pietrobom

Universidade Federal do ABC

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Maraisa Sachini

Universidade Federal de Pelotas

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Patrick C. Nobre

Universidade Federal de Pelotas

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Rafaela B. Silva

Universidade Federal de Pelotas

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Renata G. Lara

Universidade Federal de Pelotas

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