Genette Ellis

Grand-maternal smoking in pregnancy and grandchild’s autistic traits and diagnosed autism

Although there is considerable research into the genetic background of autism spectrum disorders, environmental factors are likely to contribute to the variation in prevalence over time. Rodent experiments indicate that environmental exposures can have effects on subsequent generations, and human studies indicate that parental prenatal exposures may play a part in developmental variation. Here we use the Avon Longitudinal Study of Parents and Children (ALSPAC) to test the hypothesis that if the mother or father (F1) had been exposed to their own mother’s (F0) smoking during pregnancy, the offspring (F2) would be at increased risk of autism. We find an association between maternal grandmother smoking in pregnancy and grand daughters having adverse scores in Social Communication and Repetitive Behaviour measures that are independently predictive of diagnosed autism. In line with this, we show an association with actual diagnosis of autism in her grandchildren. Paternal grandmothers smoking in pregnancy showed no associations.

Parental External Locus of Control in Pregnancy Is Associated with Subsequent Teacher Ratings of Negative Behavior in Primary School: Findings from a British Birth Cohort

The purpose of the present study was to examine whether parents’ locus of control (LOC) obtained before the birth of their child predicts the child’s behavior at school in School Years 3 (ages 7–8) and 6 (ages 10–11). A modified version of the adult Nowicki–Strickland internal–external locus of control scale was completed by mothers and fathers in their own home during pregnancy. Externality was defined as a score greater than the median and internality as equal to, or less than, the median. Outcomes were the five individual subscales and the total difficulties of Goodman’s strengths and difficulties’ questionnaire completed by the children’s class teachers at the end of School Years 3 and 6. As predicted, it was found that the greater the presence of externality in the parents, the greater the increased risk of the child’s adverse behavior as rated by teachers. The risk was generally greatest if both parents were external and lowest if both were internal. There was a consistent relationship at both Year 3 and Year 6 between maternal externality in pregnancy and children’s emotional difficulties. However, for other behaviors, the pattern of associations varied depending on whether the mother or father was external, the type of adverse behavior, and the School Year in which children were assessed. Prenatal parental externality appears to be significantly associated with a variety of children’s negative behaviors. Of note was the finding that fathers’ as well as mothers’ LOC was important in determining children’s outcomes. Implications of the complexity of the results for the role parents may play in children’s personality and adjustment are discussed.

Events associated with stability and change in adult locus of control orientation over a six-year period

Although locus of control (LOC) has been the focus of thousands of studies we know little about how or if it changes over time and what is associated with change. Our lack of knowledge stems in part from the past use of cross-sectional and not longitudinal methodologies to study small numbers of participants from non-representative populations. The purpose of the present study was to use a longitudinal design with a large representative population to provide relevant information concerning the stability and change of adult LOC. Before the birth of their child, and again six years later, mothers and their partners participating in the Avon Longitudinal Study of Parents and Children (ALSPAC) completed LOC tests and structured stressful events surveys. Analyses revealed that stresses experienced in relationships with spouses, friends and family, financial stability and job security, and illness/smoking were associated with changes in LOC. Results suggest substantial variation of LOC within spousal/parent dyads and moderate stability of LOC over time for both men and women. Stressors associated with change in LOC may be possible candidates when considering interventions to modify LOC expectancies.

Prenatal Internal Locus of Control Is Positively Associated with Offspring IQ, Mediated through Parenting Behavior, Prenatal Lifestyle and Social Circumstances

Locus of control (LOC) is a measure that identifies the likelihood as to whether an individual considers what happens to him is largely a matter of luck or fate (known as externally oriented) or whether it is something that the individual can influence (internality). Here we have used data collected as part of the Avon Longitudinal Study of Parents and Children (ALSPAC) to determine the associations between the mothers’ LOC orientation before the birth of the child and her child’s cognition measured at age 8. Using results from 6801 children we show that maternal internal LOC is associated with increased ability in offspring IQ, as measured using the WISC, with children of internally oriented mothers having an advantage of approximately 7 IQ points at age 8. As a sensitivity analysis we used the IQ test results of a sample of 986 preschool children tested using the WPSSI at age 4. A similar advantage was found among the offspring of the internally oriented mothers. We investigated mechanistic explanations for these results firstly by determining the extent to which three separate sets of factors known to be influenced by the LOC orientation might explain these findings. We showed that (a) perinatal life-style exposures, (b) parenting attitudes and strategies and (c) socio-economic circumstances, largely explain the mechanism through which the internality of the mother influences the cognition of the child. Similar effects were found using the smaller sample tested at age 4. The results indicate that efforts made to foster internality in adolescents and young adults prior to parenthood may result in improvements in the cognitive development of the next generation. Intervention studies are urgently needed.

Are the early childhood antecedents of men’s external locus of control similar to those of their female partners?

Background: The concept of locus of control of reinforcement was introduced by Julian Rotter and has been the focus of intense research for nearly half a century. Surprisingly little research has been directed at clarifying antecedents of locus of control (LOC) orientations in adult men apart from a few small studies. We previously identified a number of independent antecedents associated with women’s LOC, including features of their parents and early childhood. This raised the question as to whether these factors were also associated with the development of LOC in men. Methods: To identify antecedents of LOC orientations in a representative population of women we previously analysed information concerning characteristics of their parents and their own childhood experiences using pregnant women taking part in the Avon Longitudinal Study of Parents and Children (ALSPAC). Here we use the same design to determine whether their male partners have similar antecedents of LOC orientation. As previously, we use a hypothesis-free exposome technique using all available information on the parents and childhood of the individuals. Results: We show that men had many of the same antecedent characteristics as the women – in particular, their mother’s year of birth and father’s social group, being exposed to cigarette smoke prenatally, starting to smoke regularly before the age of 11, and having a friend die were all associated with being external. Associations of internality common to both were warm maternal care, being breast fed, being born in an area other than that where they currently live, attending boarding school and having a parent admitted to hospital. Conclusions: In general, the antecedents of male external and internal personalities have many similarities to those of women, thus providing some features to inform the possible theoretical background as to how LOC might develop over time.

The relationship between parental locus of control and adolescent obesity: a longitudinal pre-birth cohort

ObjectivesTo investigate whether parental external locus of control (ELOC) measured in pregnancy is related to obesity in their adolescent offspring and whether the child’s own ELOC measured at age 8 contributes. To determine whether associations are due to types of behaviour used by externally oriented participants.Subjects/methodsLongitudinal pre-birth cohort study (Avon Longitudinal Study of Parents & Children (ALSPAC)) set in south-west England. Families whose adolescent offspring had their fat mass measured using DXA scans at any of ages 9, 11, 13, 15 or 17 (range, n = 7329 at 9 to n = 4850 at 17). The primary outcome measures were mean fat mass, and obesity measured as ≥85th centile of fat mass at each age.ResultsWe found that parent and child externality was associated with greater fat mass [e.g., mean difference at age 15 associated with maternal ELOC was 1.70 kg (+1.17, +2.24), paternal ELOC 1.49 kg (+0.89, +2.09) and child’s ELOC 1.50 kg (+0.93, +2.06) (P < 0.0001)]. Further analyses showed that factors associated with parent behaviour such as smoking in pregnancy, failure to breast feed, and early introduction of solids accounted for a third of the excess fat mass associated with maternal externality, whereas aspects of diet and energetic activity in later childhood were not. Further analyses demonstrated that the child’s own ELOC only became independently important for adolescent obesity from age 13, whereas the mothers’ and to a lesser extent the fathers’ ELOC were associated at each age.ConclusionsThere is increased interest in determining factors that may be involved in the aetiology and maintenance of excessive weight in adolescents. We demonstrate that parental locus of control is a promising candidate. We suggest interventions to change parents’ locus of control towards internality in pregnancy might have long-term preventative benefits on the likelihood of obesity in the offspring.

The Pattern of Stability and Change in Parental Locus of Control Over 6 Years and Teacher Ratings of Child Behavior

A previous study from our group showed that parents’ locus of control (LOC) obtained before the birth of their child was associated with the child’s behavior at school in School Years 3 (ages 7–8) and 6 (ages 10–11). Here we examine whether a change in parental LOC over the first 6 years of the child’s life was associated with differences in his or her behavior as rated by their teachers. As before, we use data from the Avon Longitudinal Study of Parents and Children (ALSPAC). A modified version of the adult Nowicki–Strickland internal–external LOC scale was completed by mothers and fathers in their own home during pregnancy and 6 years later. Externality was defined as a score greater than the median and internality as equal to, or less than, the median. Outcomes were the five individual subscales and the total difficulties of Goodman’s Strengths and Difficulties Questionnaire (SDQ) completed by the children’s class teachers at the end of School Years 3 and 6. As predicted, we found that parents who remained externally oriented, or became external, had children with more behavioral difficulties in primary school compared with parents who remained or became internal. Type of behavior difficulties varied somewhat with whether mothers or fathers remained or changed toward externality. These results support the possibility that changes in parental LOC are associated with children’s personal and social adjustment. Consequently, programs to change parental LOC may be worth evaluating.

Prenatal mercury exposure and features of autism: a prospective population study

BackgroundMercury (Hg) has been suspected of causing autism in the past, especially a suspected link with vaccinations containing thiomersal, but a review of the literature shows that has been largely repudiated. Of more significant burden is the total quantity of Hg in the environment. Here, we have used the Avon Longitudinal Study of Parents and Children (ALSPAC) to test whether prenatal exposure from total maternal blood Hg in the first half of pregnancy is associated with the risk of autism or of extreme levels of autistic traits. This is the largest longitudinal study to date to have tested this hypothesis and the only one to have considered early pregnancy.MethodsWe have used three strategies: (1) direct comparison of 45 pregnancies resulting in children with diagnosed autism from a population of 3840, (2) comparison of high scores on each of the four autistic traits within the population at risk (n~2800), and (3) indirect measures of association of these outcomes with proxies for increased Hg levels such as frequency of fish consumption and exposure to dental amalgam (n > 8000). Logistic regression adjusted for social conditions including maternal age, housing circumstances, maternal education, and parity. Interactions were tested between risks to offspring of fish and non-fish eaters.ResultsThere was no suggestion of an adverse effect of total prenatal blood Hg levels on diagnosed autism (AOR 0.89; 95% CI 0.65, 1.22) per SD of Hg (P = 0.485). The only indication of adverse effects concerned a measure of poor social cognition when the mother ate no fish, where the AOR was 1.63 [95% CI 1.02, 2.62] per SD of Hg (P = 0.041), significantly different from the association among the offspring of fish-eaters (AOR = 0.74 [95% CI 0.41, 1.35]).ConclusionIn conclusion, our study identifies no adverse effect of prenatal total blood Hg on autism or autistic traits provided the mother ate fish. Although these results should be confirmed in other populations, accumulating evidence substantiates the recommendation to eat fish during pregnancy.

Stability of, and associations between, parent and child locus of control expectancies

The purpose of the present study was to assess the stability of locus of control (LOC) scores over time using data gathered from tests constructed to be consistent with Rotter’s definition of LOC. We compared LOC scores of parents (measured prior to the birth of the index child and at 6 and 18 years later) and their offspring (at ages 8 and 16) to explore how stable adult and child LOC was over time and to see how parental LOC was associated with the LOC of the child aged 8 and again at 16. Locus of control was measured using modified versions of adult (ANSIE, Nowicki and Duke, 1974) and child (CNSIE, Nowicki and Strickland, 1973) LOC scales, administered to participants in the Avon Longitudinal Study of Parents and Children in the United Kingdom. We predicted that: (1) adult scores would be more stable than children’s and (2) parents’ and children’s LOC scores would be related to one another. Analyses of the data found that individual’s LOC scores were significantly associated over time, with adult scores (r ∼ 0.50) more highly correlated than children’s (r ∼ 0.20). Correlations suggest more stability for adults than children, but also indicate the occurrence of substantial change across time. Although statistically significant, correlations between family members were small at both childhood and adolescent time points. Additional analyses suggested that mother and father LOC scores were more highly correlated with opposite rather than with same sex children, but again though significant the coefficients were small. We also analyzed the binary outcomes of externality to assess parental contributions to externality in the 8 and 16-year-old children and found correlations were significant, but small. Possible explanations are offered for why the associations between parent and child LOC were not higher. We concluded that researchers need to focus more on clarifying how children’s LOC is acquired.

Data relating to change in locus of control orientation of parents overtime (from pre-birth to 20 years later), participating in the Avon Longitudinal Study of Parents and Children (ALSPAC)

Locus of control (LOC) measures an individual׳s expectancy regarding their ability to affect what happens to them based on their behavior. Those with an internal LOC (ILOC) believe their own behavior influences what happens to them. Those with an external LOC (ELOC) perceive that what happens to them is beyond their control (i.e. determined by luck, fate, chance or powerful others) [1]. A vast amount of research (mainly cross-sectional) suggests that an ELOC is associated with many adverse personal, social, academic and health outcomes. LOC data were uniquely collected prenatally from over 12,000 pregnant women and their partners enrolled in the Avon Longitudinal Study of Parents and Children (ALSPAC). The LOC measure used was a shortened version of the adult version of the Nowicki-Strickland Internal-External locus of control scale. This was administered to the mothers within self-completion questionnaires at three-time points: during pregnancy, at 6 and at 18 years post-partum. In parallel, self-completion questionnaires containing the same LOC questions were completed by their partners during pregnancy, at 6 and 20 years later. ALSPAC LOC data are unique in that they measured orientation over time and on a much larger sample of respondents than is usual. We describe the scale used, why it was chosen and how individual scores changed over time.