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Featured researches published by Gennaro De Rosa.


European Journal of Haematology | 2009

Danazol: in vitro effects on human hemopoiesis and in vivo activity in hypoplastic and myelodysplastic disorders

Lucio Catalano; Gennaro De Rosa; Raffaele Fontana; Rosario Notaro; Bruno Rotoli

Abstract:  We examined the effects of danazol on in vitro growth of human bone marrow and peripheral blood progenitor cells from 15 normal donors and 5 myelodysplastic patients, and on in vivo hemopoiesis in 30 patients with hypoplastic or myelodysplastic disorders. At concentrations similar to that reported as the plasma level after oral administration, danazol significantly increased CFU‐GM colony growth in all normal donors, while the influence on CFU‐E, BFU‐E, CFU‐MK and CFU‐GEMM colony growth was less evident. The stimulatory effect on CFU‐GM was observed even after accessory cell depletion. No stimulatory effect either in vitro on the growth of all hemopoietic progenitors or in vivo was observed in 15 myelodysplastic patients, while 7 complete and 3 partial hematological responses occurred in 15 patients with hypoplastic disorders. In conclusion, our results suggest that danazol exerts a direct stimulatory activity in vitro at least on CFU‐GM, and a hemopoietic stimulatory effect in vivo in hypoplastic but not in myelodysplastic disorders.


Menopause | 2007

Estrogen-progestin therapy in women after stem cell transplant: our experience and literature review.

Libuse Tauchmanovà; Gennaro De Rosa; A. Sammartino; Costantino Di Carlo; Tittania Musella; Carmen Martorelli; Gaetano Lombardi; Bruno Rotoli; Carmine Nappi; Annamaria Colao

Women undergoing stem cell transplantation (SCT) are mostly young and have more than 90% probability of ovarian failure, which is often permanent. A womans age, use of radiotherapy and alkylating chemotherapy, and the allogeneic type of transplant are associated with a higher rate of premature ovarian failure and worse residual ovarian function. Premature ovarian failure has serious systemic and psychological effects that may need treatment and should be managed by practitioners trained to treat this particular population of women. Ultrasonographic evidence of ovarian follicles is often associated with a future resumption of cycles, but there are no serum markers to predict the return of ovarian function in these patients. In our center, the rate of ovarian function recovery was 7% after allogeneic SCT and 25% after autologous SCT (P < 0.05). There are no guidelines on how to manage premature ovarian failure induced by myeloablative treatments followed by SCT. Because of the likelihood of the need for long-lasting estrogen plus progestin therapy (EPT) and the increased risk of secondary neoplasia after SCT, the EPT should be as physiological as possible. In our experience, the cyclical sequential combination of estradiol (2 mg daily) plus dydrogesterone (10 mg for 14 d/mo) was associated with excellent compliance because of its simple administration and few adverse effects. Such a treatment led to a dramatic improvement in vasomotor, urogenital, and psychological symptoms related to estrogen deficiency. However, in the allogeneic transplantation setting, up to 25% of women may suffer from gynecological chronic graft-versus-host disease, which may become apparent as hematocolpometra after introduction of EPT. Thus, accurate pretreatment evaluation and frequent monitoring during treatment are required. Moreover, EPT absorption may be reduced in patients who received allotransplants and have gastrointestinal or skin chronic graft-versus-host disease.


Transplantation | 2004

High serum leptin in patients with chronic graft-versus-host disease after hematopoietic stem cell transplantation.

Libose Tauchmanovà; Giuseppe Matarese; Carlo Carella; Gennaro De Rosa; B Serio; Patrizia Ricci; Gaetano Lombardi; Bruno Rotoli; Annamaria Colao

Background. Increased serum leptin has been described after various organ transplants, with a mechanism that is still unclear. Methods. We measured serum leptin in 60 patients before and after allogeneic (allo) or autologous (auto) stem cell transplant (SCT) and in 60 healthy controls, matched for age and body mass index (BMI). Results. Serum leptin was higher in patients after SCT than before and in controls. Leptin production was higher after allo- than after auto-SCT; the presence of chronic graft-versus-host disease (cGVHD) was associated with the highest values. The physiological correlation with BMI was lost in the allogeneic setting, indicating a strong influence of factors other than the nutritional status on circulating leptin. No relationship was found between serum leptin levels and time from transplant, age, cortisol, C-reactive protein, and T-lymphocyte CD4-to-CD8 ratio. Among the cytokines secreted by type-1/type-2 T-helper lymphocytes, only serum interferon-gamma significantly correlated with serum leptin levels. Anti-leptin blocking antibodies partially inhibited T-cell activation in mixed lymphocyte reaction, suggesting a link between leptin and T-lymphocyte activation in the allo-SCT setting. Conclusion. Taken together, these findings suggest that increased serum leptin concentrations may contribute to T-cell activation during development of cGVHD.


Hematology | 2005

Tc99m-sestaMIBI uptake in nonsecretory multiple myeloma.

Lucio Catalano; Claudia Andretta; Leonardo Pace; Silvana Del Vecchio; Barbara Salvatore; Gennaro De Rosa; Maria Teresa Buonanno; Gaetano Paone; Bruno Rotoli

Abstract Staging and monitoring of multiple myeloma (MM) is mainly based on monoclonal component quantification; the absence of such a parameter renders difficult follow up of patients with nonsecretory MM (nsMM). In this study our aims were to determine the specificity and sensitivity of Tc99m-sestaMIBI scintigraphy at diagnosis and during follow up of nsMM patients. Nine nsMM patients were prospectively studied at diagnosis and during treatment for a mean time of 33 months (range: 12–65 +). Tc99m-sestaMIBI (MIBI) scintigraphy was compared to conventional imaging (CI: X ray with CAT or NMR details) at diagnosis and during follow up. At diagnosis, CI and MIBI were concordant in three patients; CI showed more focal lesions than MIBI in four patients, while MIBI revealed more focal lesions than CI in two patients. During the follow up, MIBI uptake was normal in the four patients who achieved remission. Five patients did not achieve remission: CI and MIBI were concordant in three, while MIBI was falsely negative in two patients. In conclusion, Tc99m-sestaMIBI scintigraphy has high sensitivity (no false positive cases) and 78% specificity (2/9 false negative cases) in tracing active nsMM lesions; it should be considered complementary to CI for monitoring this rare disease.


Amyloid | 2015

Mobilization of peripheral blood hematopoietic stem cells by granulocyte-colony stimulating factor and plerixafor in patients with cardiac AL amyloidosis

Monica Galli; Federica Lessi; Alessandro Rambaldi; Marny Fedrigo; Gennaro De Rosa; Fausto Adami

Immunoglobulin light chain (AL) amyloidosis is a plasma cell (PC) dyscrasia in which amyloid deposition from misfolded monoclonal immunoglobulin light chains adversely affects organ functions. Card...


Immunology Letters | 1994

Analysis of peripheral blood normal and malignant cells with the novel murine monoclonal antibody UN2.

Pierfranceso Tassone; Patrizia Bonelli; Franca Maria Tuccillo; Maria Turco; Gennaro De Rosa; Giovanni Morrone; Luigi Cecco; Maria Carmela Cerra; Antonello Petrella; M. Nigro; Salvatore Venuta

The monoclonal antibody (mAb) UN2 was generated upon immunization of a Balb/c mouse with human thymocytes. mAb UN2 recognized an antigen expressed by a subpopulation of human thymocytes and peripheral blood lymphocytes. In thymus, mAb UN2 recognized cortical cells; its expression was higher on CD3bright than on CD3dim thymocytes. This antigen was also detected on peripheral blood granulocytes, monocytes, platelets and on cell lines MOLT4, U937 and KG1. mAb UN2 was submitted to the 5th International Workshop and Conference on Human Leukocyte Differentiation Antigens, Boston, MA, 1993, and was assigned to the CD31. Expression of the UN2-recognized antigen in malignant lymphoid cells from 57 cases of B-cell chronic lymphoproliferative disease and 4 of B-cell acute lymphoblastic leukemia was analysed in flow cytometry. Among the 57 cases of B-cell chronic lymphoproliferative malignancies studied, 49 were classified as B-cell chronic lymphocytic leukemia. These showed high (86 +/- 8%) UN2 antigen expression. In 8 cases of hairy-cell leukemia the percentage of cells reacting with mAb UN2 was 42 +/- 4%; the fluorescence intensity of labelled cells was lower than that displayed by cells of B-cell chronic lymphocytic leukemia and comparable to that of normal lymphoid cells. mAb UN2 could prove useful in analysis of the lymphoid development and diagnostics of B-cell chronic lymphoproliferative disorders.


Leukemia & Lymphoma | 2002

Multiple myeloma cured by conventional chemotherapy: A report and a review

Rosario Notaro; Amalia De Renzo; Gennaro De Rosa; Anastasios Karadimitris; Bruno Rotoli

A young man presented with overt multiple myeloma at the age of 28, and received cyclophosphamide pulses every 3-4 weeks for more than 3 years. He has remained in continuous complete remission for the past 23 years without further treatment and without evidence of disease. Five cases of multiple myeloma cured by conventional chemotherapy reported in literature are reviewed here.


American Journal of Hematology | 1997

High prevalence of hepatitis C virus infection in patients with B-cell lymphoproliferative disorders in Italy

Gennaro De Rosa; Maria Luisa Gobbo; Amalia De Renzo; Rosario Notaro; Salvatore Garofalo; Maria Grimaldi; Aurora Apuzzo; Federico Chiurazzi; Marco Picardi; Margherita Matarazzo; Bruno Rotoli


Blood | 2004

Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells

Heather M. Bond; Maria Mesuraca; Ennio Carbone; Patrizia Bonelli; Valter Agosti; Nicola Amodio; Gennaro De Rosa; Massimo Di Nicola; Alessandro M. Gianni; Malcolm A. S. Moore; Akiko Hata; Michele Grieco; Giovanni Morrone; Salvatore Venuta


The Journal of Clinical Endocrinology and Metabolism | 2002

Long-lasting bone damage detected by dual-energy x-ray absorptiometry, phalangeal osteosonogrammetry, and in vitro growth of marrow stromal cells after allogeneic stem cell transplantation.

Libuse Tauchmanovà; B Serio; Antonio Del Puente; Antonio M. Risitano; Antonella Esposito; Gennaro De Rosa; Gaetano Lombardi; Annamaria Colao; Bruno Rotoli

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Bruno Rotoli

University of Naples Federico II

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Annamaria Colao

University of Naples Federico II

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Gaetano Lombardi

University of Naples Federico II

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Libuse Tauchmanovà

University of Naples Federico II

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Carmine Nappi

University of Naples Federico II

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Marco Picardi

University of Naples Federico II

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A. Sammartino

University of Naples Federico II

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Amalia De Renzo

University of Naples Federico II

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Antonio M. Risitano

University of Naples Federico II

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