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George F Njoroge

Schering-Plough

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Publication

Featured researches published by George F Njoroge.

Bioorganic & Medicinal Chemistry Letters | 2010

Discovery of C-imidazole azaheptapyridine FPT inhibitors.

Hugh Y. Zhu; Alan B. Cooper; Jagdish A. Desai; George F Njoroge; Paul Kirschmeier; W. Robert Bishop; Corey Strickland; Alan Hruza; Ronald J. Doll; Viyyoor M. Girijavallabhan

The discovery of C-linked imidazole azaheptapyridine bridgehead FPT inhibitors is described. This novel class of compounds are sub nM FPT enzyme inhibitors with potent cellular inhibitory activities. This series also has reduced hERG activity versus previous N-linked imidazole series. X-ray of compound 10a bound to FTase revealed strong interaction between bridgehead imidazole 3N with catalytic zinc atom.

Archive | 2001

Macrocyclic ns3-serine protease inhibitors of hepatitis c virus comprising n-cyclic p2 moieties

Kevin X. Chen; Ashok Arasappan; Srikanth Venkatraman; Tejal Parekh; Haining Gu; George F Njoroge; Viyyoor M. Girijavallabhan; Ashit K. Ganguly; Anil K. Saksena; Edwin Jao; Nanhua Hugh Yao; Andrew Prongay; Vincent S. Madison; Bancha Vibulbhan

Archive | 1996

Carbonyl piperazinyl and piperidinyl compounds

Ronald J. Doll; Alan K. Mallams; Adriano Afonso; Dinanth F. Rane; George F Njoroge; Randall R. Rossman; John J. Baldwin; Ge Li; John C. Reader

Archive | 2008

HYDRAZIDO-PEPTIDES AS INHIBITORS OF HCV NS3-PROTEASE

Srikanth Venkatraman; George F Njoroge; Neng-Yang Shih

Archive | 2011

Makrocyclische inhibitoren der ns3-serinprotease des hepatitis-c-virus

Srikanth Venkatraman; George F Njoroge; Wanli Wu; Viyyoor M. Girijavallabhan; Brian Mckittrick; Jing Su; Francisco Velazquez; Patrick A. Pinto

Archive | 2010

Composés tricycliques fusionnés et leurs dérivés utiles pour le traitement de maladies virales

Stuart B. Rosenblum; Kevin X. Chen; Joseph A. Kozlowski; George F Njoroge

Archive | 2009

Neue verbindungen als inhibitoren der ns3-serinprotease des hepatitis-c-virus

Ashok Arasappan; George F Njoroge; Angela I Padilla-Acevedo; Kevin X. Chen; Frank Bennett; Mousumi Sannigrahi; Stephane L. Bogen; Srikanth Venkatraman; Edwin Jao; Anil K. Saksena; Viyyoor M. Girijavallabhan

Archive | 2008

Peptides hydrazido en tant qu'inhibiteurs de la protéase ns3 du hcv

Srikanth Venkatraman; George F Njoroge; Neng-Yang Shih

Archive | 2005

3,4-(cyclopentyl)kondensierte prolinverbindungen als inhibitoren der ns3-serinprotease des hepatitis-c-virus

George F Njoroge; Srikanth Venkatraman; Ashok Arasappan; Francisco Velazquez; Viyyoor M. Girijavallabhan

Archive | 2005

Neue verbindungen als inhibitoren der ns3-serinprotease des hepatitis-c-virus New compounds as inhibitors of the serine protease of the hepatitis ns3 C virus

Ashok Arasappan; George F Njoroge; Angela I Padilla-Acevedo; Kevin X. Chen; Frank Bennett; Mousumi Sannigrahi; Stephane L. Bogen; Srikanth Venkatraman; Edwin Jao; Anil K. Saksena; Viyyoor M. Girijavallabhan

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Collaboration

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Srikanth Venkatraman

University of Pittsburgh

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Viyyoor M. Girijavallabhan

Schering-Plough

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Ashok Arasappan

Duke University

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Kevin X. Chen

Schering-Plough

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John J. Piwinski

Schering-Plough

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Robert Bishop

Schering-Plough

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Anil K. Saksena

Schering-Plough

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Edwin Jao

Schering-Plough

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J Doll

Schering-Plough

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K Mallams

Schering-Plough

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