George M. Higgins

Effect of cortisone and ACTH on eosinophils and anaphylactic shock in guinea pigs.

Summary Guinea pigs were used throughout this study. The number of eosinophils in the blood of males was significantly lower than that in females. Cortisone reduced the number of eosinophils in the blood of males and females. ACTH produced a pronounced eosinopenia in males and nonpregnant females. Pregnancy abolished the eosinopenic effect of ACTH. Neither cortisone nor ACTH had any effect upon the degree of anaphylactic shock produced in guinea pigs by the intravenous injection of the agent to which the animals had been sensitized.

Effect of Ether Anesthesia and Amytal Anesthesia on the Erythrocytic Findings in Control and Splenectomized Dogs

Conclusions Ether anesthesia causes profound constriction of the spleen and usually produces a marked increase in the erythrocyte count, the value for the hemoglobin and the hematocrit value while sodium amytal causes the spleen to dilate markedly, which removes a considerable percentage of erythrocytes from the circulation. Our results are in full agreement with those of Searles and Essex.