George Phillips
Duke University
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Featured researches published by George Phillips.
Journal of Consulting and Clinical Psychology | 1989
Karen M. Gil; Mary Abrams; George Phillips; Francis J. Keefe
This study examines pain coping strategies in a relatively neglected pain population, sickle cell disease (SCD) patients. Seventy-nine patients diagnosed with SCD were given a structured interview to assess pain, activity level, and health care use during painful episodes. Patients also completed the SCL-90-R as an index of psychological distress and the Coping Strategies Questionnaire. Regression analyses controlled for age, sex, and disease severity measures. Results indicated that the coping strategies factors were important predictors of pain and adjustment. Individuals high on Negative Thinking and Passive Adherence had more severe pain, were less active and more distressed, and used more health care services. Individuals high on Coping Attempts were more active during painful episodes.
The American Journal of Medicine | 1997
Charles H. Pegelow; Linda Colangelo; Martin H. Steinberg; Elizabeth C. Wright; Jeanne Smith; George Phillips; Elliott Vichinsky
PURPOSE Blood pressure in individuals who have sickle cell disease has been reported to be lower than published normal values. We determine whether and to what degree this is true, using data obtained as part of a large natural history study. PATIENTS AND METHODS Blood pressure was measured annually for 3,317 subjects with sickle cell disease who were 2 years old or older. Values obtained were compared with those reported by the National Health and Nutrition Examination Survey I and II (NHANES I and II). They were further analyzed with respect to age, sex, height, weight, hematologic diagnosis, blood urea nitrogen and creatinine, stroke, and death. RESULTS Blood pressure was significantly lower in subjects with sickle cell anemia than published norms for age, race, and sex, a difference that increased with age. It correlated with body mass index, hemoglobin, measures of renal function and age, but the strength of the correlation varied among age and sex subgroups. The risk for occlusive stroke increased with systolic but not diastolic pressure. Mortality was related to elevated blood pressure in males (P < 0.05) and to a lesser extent in females (P = 0.10). In subjects with hemoglobin SC disease, blood pressure also deviated from normal but to a lesser degree. CONCLUSION Blood pressure is generally lower than normal in individuals with sickle cell anemia. Those with high values relative to this population had an increased risk of stroke and death. Blood pressure should be monitored but values obtained must be assessed relative to the lower values expected for patients with this disease. Those with blood pressure values above 140/90 mm Hg should be evaluated and considered for treatment.
Journal of Consulting and Clinical Psychology | 1992
Robert J. Thompson; Karen M. Gil; Mary Abrams; George Phillips
A transactional model of psychological adjustment to chronic illness was examined with 109 African-American adults with sickle cell disease (SCD). Good psychological adjustment was associated with lower levels of perceived daily stress and stress regarding SCD illness tasks, higher efficacy expectations, less use of palliative coping methods, less use of negative thinking/passive adherence pain-coping strategies, and family functioning characterized by high levels of support and low levels of conflict and control. Overall the underlying stress and coping conceptual model accounted for 44-50% of the variance in psychological adjustment.
Journal of Consulting and Clinical Psychology | 1992
Karen M. Gil; Mary Abrams; George Phillips; David A. Williams
This study examined 9-month follow-up data obtained from adults with sickle cell disease (SCD) participating in a longitudinal study of pain-coping strategies. Of 99 subjects completing the baseline assessment of pain-coping strategies, 89 (90%) completed a structured pain interview assessing health care use and activity reduction during painful episodes over the follow-up period. Regression analyses controlling for demographics and disease severity revealed that baseline Negative Thinking and Passive Adherence was associated with greater activity reduction and more frequent health care contacts during the subsequent 9 months. Additional correlational analyses revealed that if levels of Negative Thinking and Passive Adherence increased from baseline to follow-up, this increase was associated with even further reductions in activity level during painful episodes. Changes in disease severity were not associated with any of the follow-up measures. Comparing pain-coping strategies assessed at baseline to pain-coping strategies measured at follow-up revealed that, without intervention, pain-coping strategies were relatively stable over time.
American Journal of Hematology | 2000
Richard D. Moore; Samuel Charache; Michael L. Terrin; Franca B. Barton; Samir K. Ballas; Susan Jones; D. Strayhorn; Wendell F. Rosse; George Phillips; D. Peace; A. Johnson-Telfair; Paul F. Milner; Abdullah Kutlar; A. Tracy; S. K. Ballas; G. E. Allen; J. Moshang; B. Scott; Martin H. Steinberg; A. Anderson; V. Sabahi; Charles H. Pegelow; D. Temple; E. Case; R. Harrell; S. Childerie; Stephen H. Embury; B. Schmidt; D. Davies; Mabel Koshy
The Multicenter Study of Hydroxyurea in Sickle Cell Anemia (MSH) demonstrated the efficacy of hydroxyurea in reducing the rate of painful crises compared to placebo. We used resource utilization data collected in the MSH to determine the cost‐effectiveness of hydroxyurea. The MSH was a randomized, placebo‐controlled double‐blind clinical trial involving 299 patients at 21 sites. The primary outcome, visit to a medical facility, was one of the criteria to define occurrence of painful crisis. Cost estimates were applied to all outpatient and emergency department visits and inpatient hospital stays that were classified as a crisis. Other resources for which cost estimates were applied included hospitalization for chest syndrome, analgesics received, hydroxyurea dosing, laboratory testing, and clinic visits for management of patient care. Annualized differential costs were calculated between hydroxyurea‐ and placebo‐receiving patients. Hospitalization for painful crisis accounted for the majority of costs in both arms of the study, with an annual mean of
Behavior Therapy | 1995
Karen M. Gil; George Phillips; Deborah A. Webster; Nancy J. Martin; Mary Abrams; Merida Grant; W. Crawford Clark; Malvin N. Janal
12,160 (95% CI:
The Clinical Journal of Pain | 1990
Karen M. Gil; George Phillips; Mary Abrams; David A. Williams
9,440,
Journal of Clinical Psychology | 1996
Robert J. Thompson; Karen M. Gil; Mary Abrams; George Phillips
14,880) for hydroxyurea and
The Clinical Journal of Pain | 1994
Karen M. Gil; George Phillips; Jennifer L. Edens; Nancy J. Martin; Mary Abrams
17,290 (95% CI:
The American Journal of Medicine | 1992
George Phillips; Brian Becker; V.Antoine Keller; John L. Hartman
13,010,