George W. Huffman | Researchain

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Bioorganic & Medicinal Chemistry Letters | 1997

Synthesis of new 3-thiosubstituted carbacephem antibiotics and their activity against penicillin resistant Streptococcus pneumoniae

Larry C. Blaszczak; Clark Norman Eid; Jane E. Flokowitsch; G.Stuart Gregory; Stephen Andrew Hitchcock; George W. Huffman; Daniel Ray Mayhugh; Michael J. Nesler; David A. Preston; Mohammad Zia-Ebrahimi

The synthesis of a series of 3-thiosubstituted carbacephem derivatives is described. The compounds were assayed against penicillin susceptible, intermediate and resistant strains of Streptococcus pneumoniae. Several analogs displayed potent in vitro activity against these organisms.

Bioorganic & Medicinal Chemistry Letters | 1991

The role of sulphur in cephalosporin biosynthesis

Jack E. Baldwin; Kee-Chuan Goh; Mark E. Wood; Christopher J. Schofield; Robin D.G. Cooper; George W. Huffman

Abstract The role of sulphur in cephalosporin biosynthesis was probed by evaluation of a carbocyclic analogue of deacetoxycephalosporin C as a substrate for DAOC/DAC synthase

Journal of Organic Chemistry | 1971

Chemistry of cephalosporin antibiotics. XXI. Conversion of penicillins to cephalexin

Robert R. Chauvette; Pamela A. Pennington; Charles W. Ryan; Robin D. G. Cooper; Felicitas L. Jose; Ian Glaiby Wright; Earle Marvin Van Heyningen; George W. Huffman

Archive | 1997

Methods and compounds for inhibiting beta-amyloid peptide release and/or its synthesis

James E. Audia; Thomas C. Britton; James J. Droste; Beverly K. Folmer; George W. Huffman; Varghese John; Lee H. Latimer; Thomas Edward Mabry; Jeffrey S. Nissen; Warren J. Porter; Jon K. Reel; Eugene D. Thorsett; Jay S. Tung; Jing Wu; Clark Norman Eid; William Leonard Scott

Journal of Medicinal Chemistry | 1992

Substrate specificity of isopenicillin N synthase

George W. Huffman; Paul David Gesellchen; Jan R. Turner; Robert B. Rothenberger; Harold E. Osborne; F. Dean Miller; Jerry L. Chapman; Stephen Wyatt Queener

Journal of Medicinal Chemistry | 1971