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Featured researches published by Gerd König.


Chirality | 2010

Highly stereoselective hydrogenations—As key-steps in the total synthesis of statins

Natalia Andrushko; Vasyl Andrushko; Vitali Tararov; Andrei Korostylev; Gerd König; Armin Börner

Statins are inhibitors of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase (HMG-CoA reductase) and became the standard of care for treatment of hypercholesterolemia because of their efficacy, safety, and long-term benefits. They are administered as diastereo- and enantiomerically pure compounds. We summarize here two new approaches for the total synthesis of the most important representatives, atorvastatin, and rosuvastatin, based on highly stereoselective hydrogenations as key-steps.


Synthetic Communications | 2006

Facile Preparation and Purification of Mono tert‐Butyl Malonate

Vitali Tararov; Andrei Korostylev; Gerd König; Armin Börner

Abstract Reaction of Meldrums acid with tert‐BuOH gives tert‐BuO2CCH2CO2H, which can be easily purified via its corresponding crystalline ammonium salt and subsequent acidification.


European Journal of Organic Chemistry | 2008

A New Approach to the Total Synthesis of Rosuvastatin

Natalia Andrushko; Vasyl Andrushko; Gerd König; Anke Spannenberg; Armin Börner


Advanced Synthesis & Catalysis | 2006

Synthesis and highly stereoselective hydrogenation of the statin precursor ethyl (5S)-5,6-isopropylidenedioxy-3-oxohexanoate

Vitali Tararov; Gerd König; Armin Börner


European Journal of Organic Chemistry | 2006

Synthesis of the chiral side chain of statins - : Lactone versus lactol pathway

Vitali Tararov; Natalia Andrushko; Vasyl Andrushko; Gerd König; Anke Spannenberg; Armin Börner


European Journal of Organic Chemistry | 2008

Highly Enantioselective Hydrogenation of Ethyl 5,5-Dimethoxy-3-oxopentanoate and its Application for the Synthesis of a Statin Precursor†

Andrei Korostylev; Vasyl Andrushko; Natalia Andrushko; Vitali Tararov; Gerd König; Armin Börner


Archive | 2004

Method for the production of statins

Vitali Dr. Tararov; Gerd König; Armin Börner


Tetrahedron Letters | 2008

Synthesis of enantiopure (R)-2-(4-methoxy-3-(3-methoxypropoxy)-benzyl)-3-methylbutanoic acid—a key intermediate for the preparation of Aliskiren

Natalia Andrushko; Vasyl Andrushko; Thomas Thyrann; Gerd König; Armin Börner


Tetrahedron Letters | 2008

Highly enantioselective catalytic hydrogenation of a 5-amino-3,5-dioxopentanoic ester

Vasyl Andrushko; Natalia Andrushko; Gerd König; Armin Börner


Archive | 2007

Process for preparing C7 intermediates and their use in the preparation on N-substituted pyrrole derivatives

Andrei Korostylev; Vitali Dr. Tararov; Armin Börner; Gerd König; Pavel Bobal; Jaroslav Frantisek; Jiri Stohandl; Kane Denike; Nicolas Jeker

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Vitali Tararov

Engelhardt Institute of Molecular Biology

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Andrei Korostylev

Russian Academy of Sciences

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