Geunhyeong Jo
Konkuk University
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Featured researches published by Geunhyeong Jo.
Magnetic Resonance in Chemistry | 2011
Doseok Hwang; Jiye Hyun; Geunhyeong Jo; Dongsoo Koh; Yoongho Lim
Chalcones, intermediates in flavonoid biosynthesis, can exhibit antibacterial, antiproliferative, and anti‐inflammatory properties. Chalcones contain two benzene rings and both hydroxylated and methoxylated analogs are frequently produced by hydroxylases and O‐methyltransferases in plant biosynthetic pathways. Assignments of NMR peaks in the spectra of hydroxylated and/or methoxylated chalcones can help in identifying novel chalcone derivatives isolated from natural sources by referencing these data against NMR spectra obtained from known chalcones. We report here the syntheses of 20 chalcones and complete assignments of 1H and 13C NMR spectra. Copyright
Magnetic Resonance in Chemistry | 2012
Doseok Hwang; Geunhyeong Jo; Jiye Hyun; Sung Dae Lee; Dongsoo Koh; Yoongho Lim
A phytotoxic root exudate from Acroptilon repens was identified as 7,8‐benzoflavone, an inhibitor of cytochrome P450 1A2 and activator of cytochrome P450 3A4. The synthetic 5,6‐benzoflavone also is a potent phytotoxin. Six 7,8‐benzoflavones and eight 5,6‐benzoflavones were synthesized in this study. The NMR data for a few of these compounds have been previously reported; however, the NMR data for most of them have not been reported. For reference purposes, the complete NMR data for the 14 benzoflavones are described. Copyright
Magnetic Resonance in Chemistry | 2013
Yeonjoong Yong; Seunghyun Ahn; Doseok Hwang; Hyuk Yoon; Geunhyeong Jo; Young Hwa Kim; Sang Ho Kim; Dongsoo Koh; Yoongho Lim
Chalcones are of interest to medicinal chemists because their structures can be easily modified with various functional groups. The syntheses and biological activities of chalcones from natural sources are well known. In this study, 24 2′‐hydroxychalcones bearing methoxy substituents were synthesized, among which five are new. The NMR data for all synthesized chalcones are described for the first time. The complete assignments of the 1H and 13C NMR data can be used for the identification of newly discovered and widely isolated, synthesized chalcones. Copyright
Magnetic Resonance in Chemistry | 2012
Hyuk Yoon; Seunghyun Ahn; Doseok Hwang; Geunhyeong Jo; Dong Woon Kim; Sang Ho Kim; Dongsoo Koh; Yoongho Lim
Several types of chalcones containing 2H‐chromen group were synthesized. Claisen–Schmidt condensation of 2H‐chromen‐3‐carbaldehydes (I) with methoxy substituted acetophenones afforded (E)‐3‐(2H‐chromen‐3‐yl)‐1‐(methoxyphenyl)prop‐2‐en‐1‐ones (chromenylchalcones, 1–7). Other types of chromenylchalcone, (E)‐1‐(6‐methoxy‐2H‐chromen‐3‐yl)‐3‐(methoxyphenyl)prop‐2‐en‐1‐ones (8–13) were also obtained between reaction of methoxy substituted benzaldehydes and 1‐(6‐methoxy‐2H‐chromen‐3‐yl)ethanone (II). Dichromenylchalcones (14–16) were also synthesized through the same reaction between aldehydes (I) and ketone (II). Their complete 1H‐NMR and 13C‐NMR assignments are reported here and more polysubstituted chromenylchalcones synthesized or isolated from the natural sources in the future can be identified on the basis of the NMR data reported here. Copyright
Bioorganic & Medicinal Chemistry | 2013
Geunhyeong Jo; Seunghyun Ahn; Bong-Gyu Kim; Hye Ri Park; Young Hwa Kim; Hyun Ah Choo; Dongsoo Koh; Youhoon Chong; Joong-Hoon Ahn; Yoongho Lim
Structure-activity relationship (SAR) calculations were used to find monoamine oxidase-B (MAO-B) inhibitors by identifying pharmacophores exhibiting high inhibitory activities. Several such chromenylchalcones were designed and synthesized accordingly. Their inhibitory effects on MAO-B were determined using an HPLC-based method and an MAO-B enzyme assay kit. (E)-3-(6-Methoxy-2H-chromen-3-yl)-1-(2-methoxyphenyl)prop-2-en-1-one exhibited a half-maximal inhibitory concentration of 320 nM. Its molecular-level binding mode with the three-dimensional structure of MAO-B was elucidated using an in silico docking study. The chromenylchalcone scaffold, which is derived from natural products including isoflavonoids and chalcones, had not been previously reported as an MAO-B inhibitor.
Magnetic Resonance in Chemistry | 2011
Geunhyeong Jo; Jiye Hyun; Doseok Hwang; Young Han Lee; Dongsoo Koh; Yoongho Lim
Resveratrol is a polyphenol isolated from many natural sources including grapes, mulberries, eucalyptus, spruce, lilies, and peanuts. The hydroxyl groups in polyphenols can be substituted with various functional groups, allowing production of multiple derivatives. NMR spectroscopy is used to identify new derivatives. Since the complete NMR data of the known derivatives can be useful for identification of the newly isolated derivatives, here, we report the synthesis of 14 methoxylated stilbenes and four 1,2‐diphenylethanes and their NMR data. Copyright
Applied Biological Chemistry | 2018
Soon Young Shin; Youngshim Lee; Jihyun Park; Doseok Hwang; Geunhyeong Jo; Ji Hye Lee; Dongsoo Koh; Yoongho Lim
Cisplatin often shows the drug resistance which could limit the chemotherapeutic efficacy. Thus, it is necessary to develop anticancer agents against cisplatin-resistant cancer cells. To identify pharmacophores exhibiting the cell growth inhibitory effect against cisplatin-resistant A2780/Cis ovarian cancer cells, we prepared 35 synthetic polyphenols bearing naphthalene skeleton including naphthalenyl chalcones, naphthalenyl flavones, naphthalenyl flavanones, 4,5-dihydro-1H-pyrazol-3-yl)naphthalen-2-ols, naphthalen-1-yl-N-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamides, and 4,5-dihydro-1H-pyrazol-3-yl)naphthalen-1-ol. The correlation between their inhibitory effects and structural properties was evaluated using hologram quantitative structure activity relationship and comparative molecular field analysis. The pharmacophores derived here can lead us to design new polyphenols against the growth of cisplatin-resistant cells.
Bioorganic & Medicinal Chemistry Letters | 2010
Jiye Hyun; Yoonkyung Woo; Doseok Hwang; Geunhyeong Jo; Sunglock Eom; Younggiu Lee; Jun Cheol Park; Yoongho Lim
Bulletin of The Korean Chemical Society | 2011
Hyuk Yoon; Sunglock Eom; Jiye Hyun; Geunhyeong Jo; Doseok Hwang; Sunhee Lee; Yeonjoong Yong; Jun-Cheol Park; Young Han Lee; Yoongho Lim
Journal of The Korean Society for Applied Biological Chemistry | 2012
Sunhee Lee; Geunhyeong Jo; Doseok Hwang; Yoonkyung Woo; Younggiu Lee; Yeonjoong Yong; Kyungrai Kang; Jiye Hyun; Young-Kee Kim; Dong Woon Kim; Yoongho Lim