Younggiu Lee
Konkuk University
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Younggiu Lee.
Bioorganic & Medicinal Chemistry Letters | 2011
Doseok Hwang; Soon Young Shin; Younggiu Lee; Jiye Hyun; Yeonjoong Yong; Jun Cheol Park; Young Han Lee; Yoongho Lim
Schizandra chinensis has been known to have five predominant tastes: salty, sweet, sour, astringent, and bitter. It has also been shown to have various effects on the cardiovascular system, gastrointestinal system, anti-inflammatory, central nervous system, endocrine system, and stress protect. However, its anti-cancer activity on colon carcinoma HCT-116 cells has not been yet been examined. Thus, in this study, we attempted to isolate a compound from Schisandra chinensis that induced apoptosis in HCT-116 cells. An active compound was found and identified to be Gomisin A. It displayed apoptotic activity through caspase-7 cleavage in colon carcinoma HCT-116 cells. In addition, we further assessed the effects of this compound using long-term survival clonogenic assay with HCT116 cells.
Bioorganic & Medicinal Chemistry Letters | 2011
Sunhee Lee; Soon Young Shin; Younggiu Lee; Younghee Park; Bong Gyu Kim; Joong-Hoon Ahn; Youhoon Chong; Young Han Lee; Yoongho Lim
To produce rhamnetin using enzymatic engineering, poplar O-methyltransferase-7 and its mutants were prepared based on the rational enzyme design, and the production of rhamnetin was compared with the results obtained using the wild type enzyme. In addition, the potential of using rhamnetin as a cancer chemopreventive agent was compared with that of quercetin in MDA-MB-231 human breast cancer cells, and their bioavailabilities were tested in Dulbeccos modified Eagles medium.
Bioorganic & Medicinal Chemistry Letters | 2009
Younggiu Lee; Yoonkyung Woo; Soohyun Lee; Kyungrai Kang; Yeonjoong Yong; Jae Kyung Kim; Kwang Pyo Kim; Min-Hee Kim; Young-Kee Kim; Yoongho Lim
Using in silico docking calculations, NMR analysis of target-ligand binding, and hemolytic activity assays, we searched a 30,000-compound library for an effective inhibitor of tolaasin I, a Pseudomonas tolaasii toxin that causes virulent infection in mushrooms. Of more than 30,000 compounds screened in silico, two compounds were selected. One of these compounds, sorbitololeic acid, bound to tolaasin I and inhibited its hemolytic activity in vitro. Therefore, sorbitololeic acid can be a potential inhibitor of tolaasin I.
Bioresource Technology | 2016
Jung-Tae Kim; Younggiu Lee; Young-Doo Kim; F. Ahmadi; You-Kwan Oh; Ji-Yeon Park; W.S. Kwak
In the first experiment, the effect of two novel Lactobacillus plantarum strains was studied on the fermentation of spent mushroom substrate (SMS) through 10d of ensiling. Based on lactic acid production and lactic acid bacteria population, L. plantarum KU5 was identified as the best strain for fermentation with a 5-L bag silo. Spent mushroom substrate was ensiled with 0.5% (v/w) L. plantarum KU5 without or with 5% molasses. Silages treated with microbial inoculant and molasses had the lowest pH and the highest fermentative odors. In a second set of experiments similar to the above 5-L silo study, the simultaneous application of L. plantarum KU5 inoculant and molasses to 80-L silos improved fermentability and aerobic stability of SMS silages. For similar treatment using ton-bag silos, aerobic stability decreased and NH3-N content increased dramatically. In conclusion, sawdust-based SMS for animal use was successfully ensiled with L. plantarum KU5 inoculant and molasses.
Journal of Environmental Management | 2018
Farhad Ahmadi; Younggiu Lee; W.H. Lee; Young-Kyoon Oh; K.K. Park; W. S. Kwak
Two series of experiments were performed to investigate the aerobic preservation of fruit and vegetable discards (FVD) using sodium metabisulfite (SMB). In Exp. 1, metabisulfite was applied at 0, 2, 4, 6, and 8 g/kg FVD for 0, 3, 6, 9, and 12 d. Metabisulfite treatment at 6 and 8 g/kg FVD was highly effective in controlling putrefaction and preserving the nutrient components for 6 and 9 d, respectively. In the pilot-scale experiment (Exp. 2), SMB was applied at 0 and 8 g/kg FVD in a 600-L bucket for 0, 6, and 9 d in an outdoor environment. The SMB treatment was highly effective in maintaining the integrity and freshness of FVD, suppressing microbial proliferation, and preserving the nutrient constituents. Under the conditions of this study, SMB effectively preserved FVD in an aerobic environment, enabling their more efficient long-term recycling through livestock feed or development of value-added products.
Bulletin of The Korean Chemical Society | 2008
Eunjung Lee; Byoung-Ho Moon; Younghee Park; Sungwon Hong; Sunhee Lee; Younggiu Lee; Yoongho Lim
Bioorganic & Medicinal Chemistry Letters | 2010
Jiye Hyun; Yoonkyung Woo; Doseok Hwang; Geunhyeong Jo; Sunglock Eom; Younggiu Lee; Jun Cheol Park; Yoongho Lim
Journal of The Korean Society for Applied Biological Chemistry | 2012
Sunhee Lee; Geunhyeong Jo; Doseok Hwang; Yoonkyung Woo; Younggiu Lee; Yeonjoong Yong; Kyungrai Kang; Jiye Hyun; Young-Kee Kim; Dong Woon Kim; Yoongho Lim
Bulletin of The Korean Chemical Society | 2012
Geunhyeong Jo; Su Hyun Sung; Younggiu Lee; Bong-Gyu Kim; JunWie Yoon; Hye Ok Lee; Sang Yun Ji; Dongsoo Koh; Joong-Hoon Ahn; Yoongho Lim
Journal of The Korean Society for Applied Biological Chemistry | 2012
Geunhyeong Jo; Soon Young Shin; Younggiu Lee; Jiye Hyun; Jun Cheol Park; Hyun Su Kim; Young Han Lee; Yoongho Lim