Gil-Hyun Lee

Correlation of Glasgow Prognostic Score or Procalcitonin to Clinical Variables in Patients with Pretreatment Lung Cancer

Unfortunately, the five-year survival rate of lung cancer is relatively low compared with other cancers. Therefore, better predictors are need for prognosis, therapeutic strategy, risk stratification and predicting long-term mortality of lung cancer. Recently, increasing data suggest that Glasgow Prognostic Score (GPS) and procalcitonin levels are useful predictor cancer prognosis. In this study, we retrospectively investigated the correlation of GPS or procalcitonin to clinical variables in patients with pretreatment lung cancer. In 135 patients with pretreatment lung cancer, GPS, procalcitonin, demographic characteristics, hematological, coagulation, biochemical, inflammatory and cardiac markers were measured. Monocyte, eosinophil, basophil, neutrophil to lymphocyte ratio, red cell distribution width (RDW), platelet to lymphocyte ratio, mean platelet volume to platecrit ratio, D-dimer and prothrombin time (PT) levels were higher, whereas mean platelet volume was lower than their normal ranges. Glucose and sodium levels were low, whereas gamma glutamyl transferase (GGT), total bilirubin, creatinine and inorganic phosphorus concentrations were increase compared their normal ranges. Procalcitonin, high sensitivity C-reactive protein and troponin-I concentrations were elevated compared with their normal ranges. GPS had significantly positive or negative relations to cancer stage, hematological, coagulation, biochemical, inflammatory and troponin-I. Based on the data, we suggest that GPS may be a potent and useful predictor for prognosis, therapeutic strategy, risk stratification and predicting long-term mortality of lung cancer.

Effect of Systemic Inflammatory Regulation of Hydroponic Cultured Ginseng in Arthritis Rat

본 연구는 류마티스 관절염 동물 모델의 신장 기능 저하에 따른 수경인삼 잎 추출액의 효과 알아 보고자 하였다. 류마티스 관절염 동물 모델은 타입 II collagen + adjuvant를 7일동안 연속적으로 쥐 의 꼬리에 주입하였다. 실험군은 그룹I: Control 그룹(n=5), 그룹II: collagen 주입군, 그룹III: collagen 주입 + 수경인삼 잎 추출액 200mg/kg 투여군, 그룹IV: collagen 주입 + 수경인삼 잎 추출액 100mg/kg 투여군, 그룹V: collagen 주입 + 수경인삼 잎 추출액 50mg/kg 투여군, 그룹VI: collagen 주입 + leflunomide 3.5mg/kg 투여군으로 나누었다. 우리는 혈액검사와 생화학검사를 통한 혈액학적 변화를 통해 신장기능 효과에 대한 실험을 하였고, 단백질정량분석을 통한 그룹간의 신호전달 단백질 발현의 차이를 조사하였다. 실험결과는 수경인삼 잎 추출액의 경구투여가 신장기능 유지 및 전신성 염증 조절을 할 수 있을 것으로 시사된다.

The Influence of Korean Berchemia berchemiaefolia (Makino)Koidz Extract on Nonalcoholic Hepatic Steatosis in Rats

This study was designed to examine effects of Korean Berchemia berchemiaefolia (Makino) Koidz (BBK) on diet induced-fatty liver. 45 male SD rats were divided into three groups: normal diet (control group, n=15), 40% fat diet-induced obese rats (fat group, n=15), and BBK extract diet with 40% fat diet-induced obese rats (BBK group, n=15). Hematological and biochemical variables were measured. Total Received (April 20, 2015), Review Request(April 21, 2015), Review Result(May 06, 2015) Accepted(May 27, 2015), Published(June 30, 2015) (Corresponding Author) 609-757 Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan, Busan ,Korea email: scchoi@cup.ac.kr 614-714 Department of Clinical Laboratory Science, College of Nursing & Healthcare Sciences, Dong-Eui University, Busan ,Korea email: 0167979575@nate.com 614-714 Department of Clinical Laboratory Science, College of Nursing & Healthcare Sciences, Dong-Eui University, Busan , Korea email: rokmagnum@naver.com *This paper was supported by RESEARCH FUND offered from Catholic University of Pusan This work was supported by the Brain Busan 21 Project in 2015. The Influence of Korean Berchemia berchemiaefolia (Makino) Koidz Extract on Nonalcoholic Hepatic Steatosis in Rats Copyright c 2015 HSST 132 leukocyte, neutrophil, neutrophil/lymphocyte ratio, erythrocyte, platelet, hemoglobin, and red distribution width levels were significantly lower than in BBK group than in fatty group. Glucose, total cholesterol, triglyceride, LDL-cholesterol, and BUN levels in BBK group were significantly lower than those of fatty group. BBK group showed significantly lower liver fatty degeneration (steatosis). These results suggest that Korean Berchemia berchemiaefolia (Makino) Koidz exerts anti-inflammatory, anti-obesity and ameliorative liver fatty degeneration effects.

Control Effect of Hypothalamic-Pituitary-Adrenal Axis with Cinnamon (Cinnamomum japonicum) Extract

Cinnamomum japonicum(CCE) is a genus of plants in the family Cinnamomum. Traditionally CCE has been already used for traditional medicine in Korea. But the study about antidepressant-like activity and related molecular mechanisms of CCE were not studied well. The effects of subacute treatment with CCE(100 and 200 mg/kg, p.o.) on immobility and FST-induced changes of immune parameters were investigated by using the forced swimming test (FST) in rats. As a result, CCE immobility decreases with a dose-dependency in the FST. The levels of cortisol, IL-6, IL-1β, and TNF-α of treatment group were significantly decreased than those of the FST group. Similarly p-p65 and p-65 activity of treatment group were decreased than those of the FST group. In all, these results indicate that CCE extract can be a very effective treatment for depression, suggesting that The down-regulation of NFkB activity is related to Antidepressant Effect of Berchemia berchemiaefolia.

Neuroprotection by Glycyrrhiza Uralensis Extract in Anxiety Animal Model Involves the iNOS/Nrf2 Pathway

Anxiety is a most common psychological disease, caused by stress. Many drugs for treated anxiety have various side effects and natural resources have a possibility as alternate material to eradicate these side effects. In this study is investigate inflammation modulate effects of Glycyrrhiza uralensis (GU) Extract in Forced Swimming Test (FST) induced depression rat model. 1 day after FST implemented during 15 min to training for rats, we measured FST and Y-maze test during each 6min, 3min to lock for acute effects of GU Extract, likewise measured behavior response with same method for chronic effects of GU Extract. We Received (May 07, 2015), Review Request(May 08, 2015), Review Result(May 26, 2015) Accepted(June 15, 2015), Published(August 31, 2015) 614-714 Dept. Clinical Laboratory Science, Dong-Eui Univ., Gaya 1-dong, Busanjin-gu, Busan, Korea email: excikind@naver.com 614-714 Dept. Clinical Laboratory Science, Dong-Eui Univ., Gaya 1-dong, Busanjin-gu, Busan, Korea email: rokmagnum@naver,com (Corresponding Author) 614-714 Dept. Clinical Laboratory Science, Dong-Eui Univ., Gaya 1-dong, Busanjin-gu, Busan, Korea email: kyhyun@deu.ac.kr Neuroprotection by Glycyrrhiza uralensis Extract in Anxiety animal Model Involves the iNOS/Nrf2 Pathway Copyright c 2015 HSST 156 orally administerd EU extract 100mg/kg and Sodium Tianeptine 10mg/kg. Researcher result showed oral administration of GUF Extracts significantly redused immobility time and increased total entries, total distance, down regulation of iNOS, Nrf2 expression in medulla oblongata and adrenal gland, anti-anxiety modulatory effect.

Antidepressant Effect of Acer tegmentosum Maxim on Forced Swimming Test in the Rat

Acer tegmentosum Maxim (AT) is a species of the maple genus, which is native to North-Eastern China and Korea. Traditionally, AT has been already used for pain relief in Korea. On the other hand, its antidepressant-like activity and related molecular mechanisms is not completely understood. Using the Forced Swimming Test (FST), the effects of a subacute treatment with AT(100, 200, and 400 mg/kg, p.o.) on the immobility and FST-induced changes to the immune parameters, cortisol, ACTH, and cytokine, in rats were investigated. The tendency of immobility showed a dose-dependent decrease in FST. The levels of cortisol, IL-6 and IL-1β in the peripheral blood were increased significantly after FST exposure. Overall, these results suggest that AT treatment can decrease the immobility time and the release of pro-inflammatory cytokines in the FST, suggesting that the anti-inflammatory effects of AT might be involved in the antidepressant-like effect.