Gladys Dart

Effect of organ culture on the survival of thyroid allografts in mice.

Mouse thyroid can be maintained in organ culture for 4 weeks. Uncultured BALB/c thyroid is rejected 10–15 days after transplantation under the kidney capsule of H-2 disparate recipients (C57BL, CBA). Organ culture of thyroid tissue prior to transplantation prolongs allograft survival. This prolongation of graft survival increases with increasing time in culture and 80–90% of BALB/c thyroids maintained in culture for 26 days survive in allogeneic CBA recipients for a 60− to 70-day test period. These allografts show normal function as measured by 125I uptake, and show no histological evidence of chronic rejection. Cultured allografts can be rejected if the hosts immune-system is stimulated with viable leukocytes of donor origin. Host animals carrying a functioning allograft are not tolerant of donor tissues and will reject a second uncultured allograft from the same donor strain.

Are centrilobular emphysema and panlobular emphysema two different diseases

Abstract The study of the pathogenesis of emphysema would be substantially aided if two types of emphysema, centrilobular and panlobular, could be clearly identified as separate diseases with separate pathogeneses. A study was therefore undertaken to test observer agreement on emphysema typing and to determine whether clinical or radiologic differences between these two types could be identified. Emphysema typing was found to be more difficult than the published literature indicates. This experience re-emphasizes previous findings that emphysema is often mixed in type, and that a common source of disagreement in typing is the relative weight given to each type. Only one previously published difference between centrilobular and panlobular emphysema is confirmed: the former tends to be located predominantly in the upper lung whereas the latter does not. It cannot be concluded from our data that the two types either do or do not constitute separate diseases. The difference in predominant location is in favor of such a distinction but all other findings suggest no distinction.

The Pathogenesis of Chronic Airway Obstruction.

Excerpt Between 1959 and 1968 special studies were made of the lungs from 500 autopsied subjects—mostly men and all over 40 year old—with and without chronic airway obstruction. Attention was focus...