Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where Goreti Ribeiro Morais is active.

Publication


Featured researches published by Goreti Ribeiro Morais.


Applied Radiation and Isotopes | 2009

Radioiodinated ligands for the estrogen receptor: Effect of different 7-cyanoalkyl chains on the binding affinity of novel iodovinyl-6-dehydroestradiols

Carina Neto; Maria Cristina Oliveira; Lurdes Gano; Fernanda Marques; Isabel Santos; Goreti Ribeiro Morais; Takumi Yasuda; Thies Thiemann; Filomena Botelho; Carlos Oliveira

Three novel 17 alpha-ethynyl-Delta(6,7)-estra-3,17beta-diols and their 17 alpha-[(125)I]-iodovinyl derivatives, containing different C7-cyanoalkyl chains, were studied as potential radioligands for the estrogen receptor. The influence of the chain length on the biological behaviour of the compounds was assessed through in vitro ER binding assays of the ethynyl derivatives and breast cancer cell uptake studies of the 17 alpha-[(125)I]-iodovinyl-Delta(6,7)-estra-3,17beta-diols. A difference in alkyl chain induced a decrease in ER binding affinities of substances, however, the receptor-binding affinities (RBA) of all compounds were lower than that of estradiol itself. In addition, a non-specific cell binding was observed which is in accordance with the encountered ethynyl RBA values suggesting that the uptake is not ER mediated.


Journal of Inorganic Biochemistry | 2017

Biophysical characterization and antineoplastic activity of new bis(thiosemicarbazonato) Cu(II) complexes

Elisa Palma; Filipa Mendes; Goreti Ribeiro Morais; Inês Rodrigues; Isabel Santos; Maria Paula Cabral Campello; Paula D. Raposinho; Isabel Correia; Sofia Gama; Dulce Belo; Vítor H. Alves; Antero J. Abrunhosa; António Paulo

Aiming to explore alternative mechanisms of cellular uptake and cytotoxicity, we have studied a new family of copper(II) complexes (CuL1-CuL4) with bis(thiosemicarbazone) (BTSC) ligands containing pendant protonable cyclic amines (morpholine and piperidine). Herein, we report on the synthesis and characterization of these new complexes, as well as on their biological performance (cytotoxic activity, cellular uptake, protein and DNA binding), in comparison with the parental CuIIATSM (ATSM=diacetyl-bis(N4-methylthiosemicarbazonate) complex without pendant cyclic amines. The new compounds have been characterized by a range of analytical techniques including ESI-MS, IR spectroscopy, cyclic voltammetry, reverse-phase HPLC and X-ray spectroscopy. In vitro cytotoxicity studies revealed that the copper complexes are cytotoxic, unlike the corresponding ligands, with a similar potency to that of CuATSM. Unlike CuATSM, the new complexes were able to circumvent cisplatin cross-resistance. The presence of the protonable cyclic amines did not lead to an enhancement of the interaction of the complexes with human serum albumin or calf thymus DNA. However, CuL1-CuL4 showed a remarkably augmented cellular uptake compared with CuATSM, as proved by uptake, internalization and externalization studies that were performed using the radioactive congeners 64CuL1-64CuL4. The enhanced cellular uptake of CuL1-CuL4 indicates that this new family of CuIIBTSC complexes deserves to be further evaluated in the design of metallodrugs for cancer theranostics.


Mini-reviews in Organic Chemistry | 2006

C7-Substituted Estranes and Related Steroids

Goreti Ribeiro Morais; Naho Yoshioka; Masataka Watanabe; Shuntaro Mataka; Cristina das Neves Oliveira; Thies Thiemann

C7-substituted steroids, especially C7-substituted estradiol derivatives, have been the subject of intensive interdisciplinary studies encompassing the fields of chemistry, biochemistry and medicine. While showing the more pertinent structures with their physiological characteristics, this review will focus on the synthetic approaches to these molecules.


European Journal of Organic Chemistry | 2013

Carbohydrate-Based Molecules for Molecular Imaging in Nuclear Medicine

Goreti Ribeiro Morais; Robert A. Falconer; Isabel Santos


The Journal of Steroid Biochemistry and Molecular Biology | 2013

Progesterone receptor targeting with radiolabelled steroids: An approach in predicting breast cancer response to therapy

Susana Cunha; Lurdes Gano; Goreti Ribeiro Morais; Thies Thiemann; Maria Cristina Oliveira


Organic and Biomolecular Chemistry | 2015

Isostructural Re(I)/99mTc(I) tricarbonyl complexes for cancer theranostics

Patrique Nunes; Goreti Ribeiro Morais; Elisa Palma; Francisco J. Silva; Maria Cristina Oliveira; V. F. Ferreira; Filipa Mendes; Lurdes Gano; Hugo Vicente Miranda; Tiago F. Outeiro; Isabel Santos; António Paulo


Archive | 2005

Areno Annelated Estranes by Intermolecular Cycloaddition

Goreti Ribeiro Morais; Masataka Watanabe; Shuntaro Mataka; Kyoko Ideta; Thies Thiemann


Journal of Heterocyclic Chemistry | 2017

Synthesis and Biological Evaluation of Novel 2-Aryl Benzimidazoles as Chemotherapeutic Agents

Goreti Ribeiro Morais; Elisa Palma; Fernanda Marques; Lurdes Gano; Maria Cristina Oliveira; Antero Abrunhosa; Hugo Vicente Miranda; Tiago F. Outeiro; Isabel Santos; António Paulo


Journal of Chemical Crystallography | 2012

X-ray Diffraction Structures of Regioisomers of N-Methylated Benzimidazole Compounds with Interest for the Design of Amyloid-Avid Probes

Goreti Ribeiro Morais; Isabel Santos; António Paulo


Saúde & Tecnologia | 2015

Sondas moleculares para a deteção de placas β-amilóide na doença de Alzheimer

Letícia do Quental; Goreti Ribeiro Morais; Isabel Santos; António Paulo

Collaboration


Dive into the Goreti Ribeiro Morais's collaboration.

Top Co-Authors

Avatar

Isabel Santos

Instituto Superior Técnico

View shared research outputs
Top Co-Authors

Avatar

António Paulo

Instituto Superior Técnico

View shared research outputs
Top Co-Authors

Avatar

Lurdes Gano

Instituto Superior Técnico

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar

Thies Thiemann

United Arab Emirates University

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar

Fernanda Marques

Instituto Superior Técnico

View shared research outputs
Top Co-Authors

Avatar

Filipa Mendes

Instituto Superior Técnico

View shared research outputs
Top Co-Authors

Avatar

Hugo Vicente Miranda

Instituto de Medicina Molecular

View shared research outputs
Top Co-Authors

Avatar
Researchain Logo
Decentralizing Knowledge