Goreti Ribeiro Morais
Instituto Superior Técnico
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Featured researches published by Goreti Ribeiro Morais.
Applied Radiation and Isotopes | 2009
Carina Neto; Maria Cristina Oliveira; Lurdes Gano; Fernanda Marques; Isabel Santos; Goreti Ribeiro Morais; Takumi Yasuda; Thies Thiemann; Filomena Botelho; Carlos Oliveira
Three novel 17 alpha-ethynyl-Delta(6,7)-estra-3,17beta-diols and their 17 alpha-[(125)I]-iodovinyl derivatives, containing different C7-cyanoalkyl chains, were studied as potential radioligands for the estrogen receptor. The influence of the chain length on the biological behaviour of the compounds was assessed through in vitro ER binding assays of the ethynyl derivatives and breast cancer cell uptake studies of the 17 alpha-[(125)I]-iodovinyl-Delta(6,7)-estra-3,17beta-diols. A difference in alkyl chain induced a decrease in ER binding affinities of substances, however, the receptor-binding affinities (RBA) of all compounds were lower than that of estradiol itself. In addition, a non-specific cell binding was observed which is in accordance with the encountered ethynyl RBA values suggesting that the uptake is not ER mediated.
Journal of Inorganic Biochemistry | 2017
Elisa Palma; Filipa Mendes; Goreti Ribeiro Morais; Inês Rodrigues; Isabel Santos; Maria Paula Cabral Campello; Paula D. Raposinho; Isabel Correia; Sofia Gama; Dulce Belo; Vítor H. Alves; Antero J. Abrunhosa; António Paulo
Aiming to explore alternative mechanisms of cellular uptake and cytotoxicity, we have studied a new family of copper(II) complexes (CuL1-CuL4) with bis(thiosemicarbazone) (BTSC) ligands containing pendant protonable cyclic amines (morpholine and piperidine). Herein, we report on the synthesis and characterization of these new complexes, as well as on their biological performance (cytotoxic activity, cellular uptake, protein and DNA binding), in comparison with the parental CuIIATSM (ATSM=diacetyl-bis(N4-methylthiosemicarbazonate) complex without pendant cyclic amines. The new compounds have been characterized by a range of analytical techniques including ESI-MS, IR spectroscopy, cyclic voltammetry, reverse-phase HPLC and X-ray spectroscopy. In vitro cytotoxicity studies revealed that the copper complexes are cytotoxic, unlike the corresponding ligands, with a similar potency to that of CuATSM. Unlike CuATSM, the new complexes were able to circumvent cisplatin cross-resistance. The presence of the protonable cyclic amines did not lead to an enhancement of the interaction of the complexes with human serum albumin or calf thymus DNA. However, CuL1-CuL4 showed a remarkably augmented cellular uptake compared with CuATSM, as proved by uptake, internalization and externalization studies that were performed using the radioactive congeners 64CuL1-64CuL4. The enhanced cellular uptake of CuL1-CuL4 indicates that this new family of CuIIBTSC complexes deserves to be further evaluated in the design of metallodrugs for cancer theranostics.
Mini-reviews in Organic Chemistry | 2006
Goreti Ribeiro Morais; Naho Yoshioka; Masataka Watanabe; Shuntaro Mataka; Cristina das Neves Oliveira; Thies Thiemann
C7-substituted steroids, especially C7-substituted estradiol derivatives, have been the subject of intensive interdisciplinary studies encompassing the fields of chemistry, biochemistry and medicine. While showing the more pertinent structures with their physiological characteristics, this review will focus on the synthetic approaches to these molecules.
European Journal of Organic Chemistry | 2013
Goreti Ribeiro Morais; Robert A. Falconer; Isabel Santos
The Journal of Steroid Biochemistry and Molecular Biology | 2013
Susana Cunha; Lurdes Gano; Goreti Ribeiro Morais; Thies Thiemann; Maria Cristina Oliveira
Organic and Biomolecular Chemistry | 2015
Patrique Nunes; Goreti Ribeiro Morais; Elisa Palma; Francisco J. Silva; Maria Cristina Oliveira; V. F. Ferreira; Filipa Mendes; Lurdes Gano; Hugo Vicente Miranda; Tiago F. Outeiro; Isabel Santos; António Paulo
Archive | 2005
Goreti Ribeiro Morais; Masataka Watanabe; Shuntaro Mataka; Kyoko Ideta; Thies Thiemann
Journal of Heterocyclic Chemistry | 2017
Goreti Ribeiro Morais; Elisa Palma; Fernanda Marques; Lurdes Gano; Maria Cristina Oliveira; Antero Abrunhosa; Hugo Vicente Miranda; Tiago F. Outeiro; Isabel Santos; António Paulo
Journal of Chemical Crystallography | 2012
Goreti Ribeiro Morais; Isabel Santos; António Paulo
Saúde & Tecnologia | 2015
Letícia do Quental; Goreti Ribeiro Morais; Isabel Santos; António Paulo