Grace Mann
Exelixis
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Publication
Featured researches published by Grace Mann.
Bioorganic & Medicinal Chemistry Letters | 2012
Thimothy Patrick Forsyth; Patrick Kearney; Byung Gyu Kim; Henry William Beecroft Johnson; Naing Aay; Arlyn Arcalas; David S. Brown; Chan; Jason Chen; Hongwang Du; Sergey Epshteyn; Adam Antoni Galan; Tai Phat Huynh; Mohamed Abdulkader Ibrahim; Brian Kane; Elena S. Koltun; Grace Mann; Lisa E. Meyr; Matthew Sangyup Lee; Gary L. Lewis; Robin Tammie Noguchi; Michael Pack; Brian Hugh Ridgway; Xian Shi; Craig Stacy Takeuchi; P Zu; James W. Leahy; John M. Nuss; R Aoyama; Stefan Engst
We report the discovery of a series of 4-aryl-2-aminoalkylpyrimidine derivatives as potent and selective JAK2 inhibitors. High throughput screening of our in-house compound library led to the identification of hit 1, from which optimization resulted in the discovery of highly potent and selective JAK2 inhibitors. Advanced lead 10d demonstrated a significant dose-dependent pharmacodynamic and antitumor effect in a mouse xenograft model. Based upon the desirable profile of 10d (XL019) it was advanced into clinical trials.
Archive | 2004
Lynne Canne Bannen; Diva Sze-Ming Chan; Jeff Chen; Lisa Esther Dalrymple; Timothy Patrick Forsyth; Tai Phat Huynh; Vasu Jammalamadaka; Richard George Khoury; James W. Leahy; Morrisson B. Mac; Grace Mann; Larry W. Mann; John M. Nuss; Jason Jevious Parks; Craig Stacy Takeuchi; Yong Wang; Wie Xu
Archive | 2003
Chris A. Buhr; Tae-Gon Baik; Sunghoon Ma; Zerom Tesfai; Longcheng Wang; Erick Wang Co; Sergey Epshteyn; Abigail R. Kennedy; Baili Chen; Larisa Dubenko; Neel Kumar Anand; Tsze H. Tsang; John M. Nuss; Csaba J. Peto; Kenneth D. Rice; Mohamed Abdulkader Ibrahim; Kevin Luke Schnepp; Xian Shi; James W. Leahy; Jeff Chen; Lisa Esther Dalrymple; Thimothy Patrick Forsyth; Tai Phat Huynh; Grace Mann; Lary Wayne Mann; Craig Stacy Takeuchi
Archive | 2007
Lynne Canne Bannen; Diva Sze-Ming Chan; Jeff Chen; Lisa Esther Dalrymple; Timothy Patrick Forsyth; Tai Phat Huynh; Vasu Jammalamadaka; Richard George Khoury; James W. Leahy; Morrison B. Mac; Grace Mann; Larry W. Mann; John M. Nuss; Jason Jevious Parks; Craig Stacy Takeuchi; Yong Wang; Wei Xu
Archive | 2002
Lynne Canne Bannen; Jeff Chen; Lisa Esther Dalrymple; Brenton T. Flatt; Timothy Patrick Forsyth; Xiao-Hui Gu; Morrison B. Mac; Larry W. Mann; Grace Mann; Richard Martin; Raju Mohan; Brett Murphy; Michael Charles Nyman; William C. Stevens; Tie-Lin Wang; Yong Wang; Jason H. Wu
Archive | 2007
Grace Mann; Naing Aay; Arlyn Arcalas; S. David Brown; Wai Ki Vicky Chan; Jeff Chen; Hongwang Du; Sergey Epshteyn; Timothy Patrick Forsyth; Adam Antoni Galan; Tai Phat Huynh; Mohamed Abdulkader Ibrahim; Henry William Beecroft Johnson; Brian Kane; Patrick Kearney; Byung Gyu Kim; Elena S. Koltun; James W. Leahy; Matthew Sangyup Lee; Gary L. Lewis; Lisa E. Meyr; Robin Tammie Noguchi; Michael Pack; Brian Hugh Ridgway; Xian Shi; John Woolfrey; Peiwen Zhou
Archive | 2008
Suleyman Bahceci; William Bajjalieh; Jeff Chen; Sergey Epshteyn; Timothy Patrick Forsyth; Tai Phat Huynh; Byung Gyu Kim; James W. Leahy; Matthew Sangyup Lee; Gary L. Lewis; Morrison B. Mac; Grace Mann; Charles K. Marlowe; Brian Hugh Ridgway; Joan C. Sangalang; Xian Shi; Craig Stacy Takeuchi; Yong Wang; Zerom Tesfai
Archive | 2007
Adam Antoni Galan; Jeff Chen; Hongwang Du; Timothy Patrick Forsyth; Tai Phat Huynh; Henry William Beecroft Johnson; Patrick Kearney; James W. Leahy; Matthew Sangyup Lee; Grace Mann; Brian Hugh Ridgway; Craig Stacy Takeuchi; Peiwen Zhou
Archive | 2005
Jeff Chen; Lisa E. Meyr; Sergey Epshteyn; Timothy Patrick Forsyth; Tai Phat Huynh; Mohamed Abdulkader Ibrahim; James W. Leahy; Gary L. Lewis; Grace Mann; Larry W. Mann; Robin Tammie Noguchi; Brian Hugh Ridgway; Joan C. Sangalang; Kevin Luke Schnepp; Xian Shi; Craig Stacy Takeuchi; Matthew A. Williams; John M. Nuss; Atwood Kim Cheung
Archive | 2008
Suleyman Bahceci; William Bajjalieh; Jeff Chen; Sergey Epshteyn; Timothy Patrick Forsyth; Tai Phat Huynh; Byung Gyu Kim; James W. Leahy; Matthew Sangyup Lee; Gary L. Lewis; Morrison B. Mac; Grace Mann; Charles K. Marlowe; Brian Hugh Ridgway; Joan C. Sangalang; Xian Shi; Craig Stacy Takeuchi; Yong Wang
