Gregor Stobrawa

First efficacy and safety study of femtosecond lenticule extraction for the correction of myopia Six-month results

PURPOSE: To prospectively study the feasibility of femtosecond lenticule extraction (FLE), a new method of refractive correction. SETTING: Department of Ophthalmology, Philipps University of Marburg and Helios Clinic, Erfurt, Germany. METHODS: A flap and a lenticule of intrastromal corneal tissue were simultaneously cut with a VisuMax femtosecond laser system. Next, the lenticule was manually removed and the flap repositioned. The target refraction in all cases was −0.75 diopter (D). RESULTS: All 10 myopic eyes in the initial treatment group completed the final 6‐month follow‐up. The mean patient age was 39 years. The mean spherical equivalent (SE) was −4.73 ± 1.48 (SD) preoperatively and −0.33 ± 0.61 D 6 months postoperatively. Ninety percent of eyes were within ±1.00 D and 40% were within ±0.50 D of the intended correction. No eye lost 2 or more Snellen lines. Corneal topography showed large, prolate optical zones. Aberrometry showed no significant induction of higher‐order aberrations. On a standardized questionnaire, all patients said they were very satisfied with the results. CONCLUSIONS: Preliminary results indicate that FLE is a promising new corneal refractive procedure to correct myopia.

Scanning-Fit Analysis of fs-Spectroscopic Data

The scanning-fit method was developed for the global data analysis of pump-probe data. This method is useful in cases when pulse durations are adjusted to be short compared with nuclear dynamics and long compared with the dephasing timescales. Then multiexponential functions can be used to describe the mono molecular relaxation processes and the scanning-fit method increases the accuracy of the calculated time constants, yields detailed information about their ranges of confidence and their dependency from each other. In this paper we describe the method in detail and demonstrate its application to simulated data. Additionally, we report about the results which were obtained from scanning-fit analysis in case of the photoisomerization of pinacyanol and the light induced processes in phycocyanobilin.