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Guenter Grethe

Hoffmann-La Roche

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Publication

Featured researches published by Guenter Grethe.

Synthetic Communications | 1972

Total Synthesis of Dihydrocinchonamine

Guenter Grethe; Hsi Lin Lee; Milan R. Uskokovic

Abstract Cinchonamine (1) is the best known member of a small group of 2,2-indolquinuclidine alkaloids found in the bark of certain Cinchona and Remijia species 1 and in the leaves of Isertia hypoleuca2. Its isolationwas reported in 18813, the ambiguities was elucidated in 19504, and very recently5 th ambiguities concerning the absolute configuration at C-3 were resolved. Synthetic efforts resulted in the partial synthesis of cinchonamine6, dihydrocinchonamine7,8, and its 10-methoxy-analog5,9 from cinchonine, cinchonidine and quinine.

Journal of Organic Chemistry | 1970

Cherylline, a 4-phenyl-1,2,3,4-tetrahydroisoquinoline alkaloid

Arnold Brossi; Guenter Grethe; Sidney Teitel; William C. Wildman; David Tiffany. Bailey

Journal of Organic Chemistry | 1968

Syntheses in the isoquinoline series. Synthesis of 2,3-dihydro-4(1H)-isoquinolones

Guenter Grethe; Hsi Lin Lee; Milan R. Uskokovic; Arnold Brossi

Journal of the American Chemical Society | 1978

Total synthesis of Cinchona alkaloids. 1. Synthesis of meroquinene

Milan R. Uskokovic; Thomas Henderson; Charles Reese; Hsi Lin Lee; Guenter Grethe; Juerg Albert Walter Gutzwiller

Journal of the American Chemical Society | 1978

Total synthesis of Cinchona alkaloids. 4. Syntheses via quinuclidine precursors

Guenter Grethe; Hsi Lin Lee; Toomas Mitt; Milan R. Uskokovic

Archive | 1970

4-PHENYL ISOQUINOLINES AND PROCESS FOR PREPARING SAME

Guenter Grethe; Milan R. Uskokovic

Journal of Organic Chemistry | 1968

Syntheses in the isoquinoline series. Synthesis and chemical transformation of 2,3-dihydro-4(1H)-isoquinolones

Guenter Grethe; Hsi Lin Lee; Milan R. Uskokovic; Arnold Brossi

Helvetica Chimica Acta | 1967

Rac. cis‐ und trans‐ 1, 2‐Dimethyl‐4‐hydroxy‐6, 7‐dimethoxy‐1, 2, 3, 4‐tetrahydro‐isochinolin, Synthese und Stereochemie

Guenter Grethe; M. Uskokovice; Thomas H. Williams; A. Brossi

Journal of the American Chemical Society | 1971

Synthesis of cinchona alkaloids via quinuclidine precursors

Guenter Grethe; Hsi Lin Lee; Toomas Mitt; Milan R. Uskokovic

Journal of the American Chemical Society | 1971

Epimeric 3-vinyl-4-piperdineacetic acids, synthetic precursors of cinchoma and indole alkaloids

Milan R. Uskokovic; C. Reese; Hsi Lin Lee; Guenter Grethe; Juerg Albert Walter Gutzwiller

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Collaboration

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Milan R. Uskokovic

Rutgers University

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Hsi Lin Lee

Hoffmann-La Roche

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Toomas Mitt

Hoffmann-La Roche

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Thomas H. Williams

Hoffmann-La Roche

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Arnold Brossi

University of North Carolina at Chapel Hill

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Juerg Albert Walter Gutzwiller

Hoffmann-La Roche

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John Sereno

Hoffmann-La Roche

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A. Brossi

Hoffmann-La Roche

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Sidney Teitel

Hoffmann-La Roche

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Fausto Eugenio Schenker

Hoffmann-La Roche

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