Guo-Cang Wang

Synthesis, characterization and in vitro antitumor activity of some arylbismuth triphenylgermylpropionates and crystal structures of (4-BrC6H4)3Bi(O2CCH2CH2GePh3)2 and (4-BrC6H4)3Bi[O2CCH(CH3)CH2GePh3]2

Abstract A series of novel arylbismuth(V) triphenylgermylpropionates with the formula Ar 3 Bi(O 2 CCHR 1 CHR 2 GePh 3 ) 2 (R 1 =H, CH 3 ; R 2 =H, Ph; Ar=Ph, 4-CH 3 C 6 H 4 , 4-FC 6 H 4 , 4-ClC 6 H 4 , 4-BrC 6 H 4 ) were synthesized and characterized by elemental analysis, IR, 1 H-NMR and mass spectroscopy. The crystal structures of (4-BrC 6 H 4 ) 3 Bi(O 2 CCH 2 CH 2 GePh 3 ) 2 and (4-BrC 6 H 4 ) 3 Bi[O 2 CCH(CH 3 )CH 2 GePh 3 ] 2 were determined by X-ray diffraction. Three human neoplastic cell lines (HCT-8, Bel-7402 and KB) were used to screen these compounds. The results indicate that some compounds at 5 μM show good in vitro antitumor activities.