Jin-Shan Li

Synthesis, characterization and antitumor activity of some arylantimony triphenylgermanylpropionates and crystal structures of Ph3GeCH(Ph)CH2CO2SbPh4 and [Ph3GeCH2CH(CH3)CO2]2Sb(4-ClC6H4)3

A series of novel arylantimony(V) triphenylgermanylpropionates with the formula (Ph 3 GeCHR 1 CHR 2 CO 2 ) n SbAr (5− n ) (R 1 =H, Ph; R 2 =H, CH 3 ; n =1, 2) were synthesized and characterized by elemental analysis, IR, 1 H-NMR, 13 C-NMR and mass spectroscopy. The crystal structures of Ph 3 GeCH(Ph)CH 2 CO 2 SbPh 4 and [Ph 3 GeCH 2 CH(CH 3 )CO 2 ] 2 Sb(4-ClC 6 H 4 ) 3 were determined by X-ray diffraction. The in vitro antitumor activities of some selected compounds against five cancer cells are reported.

Synthesis, characterization and in vitro antitumor activity of some arylbismuth triphenylgermylpropionates and crystal structures of (4-BrC6H4)3Bi(O2CCH2CH2GePh3)2 and (4-BrC6H4)3Bi[O2CCH(CH3)CH2GePh3]2

Abstract A series of novel arylbismuth(V) triphenylgermylpropionates with the formula Ar 3 Bi(O 2 CCHR 1 CHR 2 GePh 3 ) 2 (R 1 =H, CH 3 ; R 2 =H, Ph; Ar=Ph, 4-CH 3 C 6 H 4 , 4-FC 6 H 4 , 4-ClC 6 H 4 , 4-BrC 6 H 4 ) were synthesized and characterized by elemental analysis, IR, 1 H-NMR and mass spectroscopy. The crystal structures of (4-BrC 6 H 4 ) 3 Bi(O 2 CCH 2 CH 2 GePh 3 ) 2 and (4-BrC 6 H 4 ) 3 Bi[O 2 CCH(CH 3 )CH 2 GePh 3 ] 2 were determined by X-ray diffraction. Three human neoplastic cell lines (HCT-8, Bel-7402 and KB) were used to screen these compounds. The results indicate that some compounds at 5 μM show good in vitro antitumor activities.

SYNTHESIS, SPECTROSCOPIC CHARACTERIZATION, AND IN VITRO ANTITUMOR ACTIVITY OF TETRAPHENYLANTIMONY DERIVATIVES OF ANALOGUES OF DEMETHYLCANTHARIDIN AND DEMETHYLDEHYDROGEN-CANTHARIDIN

ABSTRACT A series of novel tetraphenylantimony(V) derivatives of the analogues of demethylcantharidin and demethyldehydrogencantharidin, exo-7-oxa-bicyclo[2,2,1]-heptane-3-arylamide-2-carboxylic acid and exo-7-oxa-bicyclo[2,2,1]-heptene-3-arylamide-2-carboxylic acid, of the general formulas , , , and have been synthesized and characterized by elemental analyses, IR, 1H NMR and mass spectroscopy. Preliminary antitumor activity tests show that these compounds have significant antitumor activity in vitro against five human neoplastic cell lines.

3-Substituted BINOL Schiff bases and their reductive products for catalytic asymmetric addition of diethylzinc to aldehydes

Three new chiral 3-substituted BINOL Schiff bases and their reductive 3-arylaminomethyl BINOL products have been synthesized and used for the asymmetric addition reaction of diethylzinc to aldehydes in the presence of titanium tetraisopropoxide. The reaction provided optically active secondary alcohols in high yield (86-100%) and good enantioselectivity (up to 92% ee).