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Medical & Biological Engineering & Computing | 1975

Continuous mass spectrographic measurement of halothane partial pressure in blood.

Melville Roberts; Ethan T. ColtonIII; Guy Owens; David D. Thomas; George M. Watkins

A method has been devised for the continuous measurement of halothane partial pressure in blood. The technique which was used in 10 dogs employs a silastic covered stainless-steel intra-arterial cannula through which blood gases pass into the analysing portion of a mass spectrometer where they are identified. Halothane produces a spectrographic peak at mass 31 which is proportional to its partial pressure. The peak at 31 results from the splitting of the halothane molecule into an ion composed of an atom of carbon and one of fluorine. The initial response time for the system is 0·4 min. The time from an initial changes to 63% of the final reading (1/e time) is 6·3 min. The calibration of the spectrometer remained stable for up to 7h, the longest test period.SommaireUne méthode a été mise au point pour mesurer en continu la pression partielle dhalothane dans le sang. La technique utilisée chez 10 chiens emploie une canule intra-artérielle en acier inoxydable et à revêtement silastic par lintermédiaire de laquelle les gaz contenus dans le sang passent dans lanalyseur dun spectromètre de masse où ils sont identifiés. Lhalothane produit une crête spectrographique à la masse à 31 qui est proportionnelle à sa pression partielle. Cette crête à 31 a pour cause la division de la molécule dhalothane en un ion composé dun atome de carbone et dun atome de fluor. Le temps de réponse initial pour le système est de 0,4 min. La durée du passage dune variation initiale demeure stable jusquà 7 heures, cest-à-dire la période dessai la plus longue.ZusammenfassungEs wurde ein Verfahren zur ständigen Messung des partiellen Drucks von Halothan im Blut gefunden. Das Verfahren, das an zehn Hunden erprobt wurde, besteht aus einer in die Arterie eingeführten Edelstahlkanüle mit silastischem Überzug, durch die die Blutgase in den analysierenden Teil eines Massenspektrometers geleitet werden, wo ihre Bestimmung erfolgt. Halothan erzeugt eine spektrographische Spitze bei 31, die im Verhältnis zu seinem partiellen Druck steht. Die Spitze bei 31 ergibt sich aus dem Spalten des Halothan-Moleküls in ein Ion, das aus einem Kohlenstoffund einem Fluor-Atom besteht. Die anfängliche Reaktionszeit des Systems beträgt 0,4 Min. Die Zeit vom anfänglichen Übergang auf 63% der Endablesung (1/e Zeit) beträgt 6,3 Min. Die Eichung des Spektrometers blieb bis zu 7 Stunden, dem längsten Versuchszeitraum, stabil.


European Surgical Research | 1974

Effects of Nitroglycerin on Myocardial Transmural Differences in Blood Flow, Oxygen and Carbon Dioxide Tensions in Normal and Ischemic Canine Hearts

Daniel Y. Loisance; Guy Owens

Changes in subepicardial and subendocardial p02, pCO2 and perfusion rate following nitroglycerin infusion have been monitored in normal and ischemic canine hearts, by a new mass-


AORN Journal | 1974

Technicians or nurses in the OR

Melvile Roberts; Juliet Vilinskas; Guy Owens

surgical specialties, from the staffs of the four hospitals was made. The surgeons were given a list of 10 statements, to which they responded with agreement or disagreement. They also had an opportunity to elaborate on their reasons for agreement or disagreement. The largest of the four hospitals, Hospital A, had the greatest preponderance of technicians, 64 to 22 nurses. At Hospital B, the VA hospital, the ratio was 6 to 5, the university hospital (C) had 6 technicians and 4 R.N.s, and Hospital D had 34 of each. None of the hos-


Journal of Neurosurgery | 1974

Solitary sclerosing plasma-cell myeloma of the spine. Case report.

Melville Roberts; Peter A. Rinaudo; Juliet Vilinskas; Guy Owens


Journal of Neurosurgery | 1972

Direct mass spectrographic measurement of regional intracerebral oxygen, carbon dioxide, and argon

Melville Roberts; Guy Owens


Journal of Trauma-injury Infection and Critical Care | 1972

Delayed Traumatic Bilateral Abducens Paralysis Without Skull Fracture Or Brain Injury

Melville Roberts; Guy Owens


Journal of Neurosurgery | 1971

Induced seizures as therapy of experimental strokes in dogs

Ronald R. Reed; Conrad H. Ciesel; Guy Owens


American Journal of Nursing | 1974

Technicians or nurses in the O.R

Melville Roberts; Juliet Vilinskas; Guy Owens


Journal of Surgical Research | 1970

Measurement of kidney parenchyma PO2 and PCO2 during in vitro perfusion

George V. Smith; Conrad H. Ciesel; Arthur A. Peterson; Guy Owens


Journal of Surgical Research | 1976

Cerebral and hepatic blood flow measured during shock using the mass spectrometer.

Frank J. Gerratana; Harry J. Saranchak; Guy Owens

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David D. Thomas

University of Connecticut

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George V. Smith

University of Connecticut

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