H.Chris Doku

Perspectives on massive osteolysis: Report of a case and review of the literature

Massive osteolysis is a rare, chronic disease characterized by the progressive dissolution of contiguous osseous structures. There is no regeneration following the osteolysis. Pathologic fracture often leads to its discovery. The etiology and pathophysiology of the disease remain obscure. Chemo- and radiotherapeutic attempts at arresting the osteolytic process are generally unsuccessful. Bone grafting has proved disappointing, as the graft usually undergoes osteolysis. A new case of facial bone involvement in a 13-year-old boy is presented. The literature is reviewed, and the clinical experience gained from treating the disease is discussed.

Early immobilization of mandibular fractures: A retrospective study

This study reviews the treatment outcome of 204 fractures in 131 patients over a 33-month period. In the total group, an infection rate of 4.4% was experienced, which is comparable with other reports. However, in complaint patients immobilized within 72 hours of injury, there was a 0% incidence of bone infection in 111 fractures treated by closed reduction and a 2% (one case) incidence of bone infection in 50 fractures treated by open reduction. Thus, of the of 161 fractures treated by closed and/or open reduction with early immobilization in complaint patients, the incidence of posttreatment bone infection was 0.6%. It was not significant whether teeth in the line of fracture were retained or removed. This study supports the principle that compound fractures of the mandible should to be immobilized within 72 hours of the initial trauma.

Mandibular osteomyelitis in the patient with chronic alcoholism: Etiology, management, and statistical correlation

Abstract Although isolated case reports of mandibular osteomyelitis complicating chronic alcoholism appeared in the literature, 1 the frequency of bone infection among patients suffering from chronic alcoholism was not generally recognized. It has become apparent from the following report that the incidence of mandibular osteomyelitis, although rare in the over-all population, increases frequently in patients with a diagnosis of chronic alcoholism. Because of this apparent unique susceptibility, oral surgeons involved in the care of these patients should bear in mind the increased potential for mandibular osteomyelitis, especially in those cases in which mandibular compound fractures are involved.

The Goldenhar syndrome: Diagnosis and early surgical management

The diagnosis, classification, pathogenesis, and surgical treatment of a child with Goldenhar syndrome is reviewed. Our experience with early costochondral growth center transplantation to the temporomandibular joint and ramus is discussed.

Arthrogryposis multiplex complex involving the temporomandibular joint

A case of arthrogryposis multiplex complex involving the temporomandibular joints is reported. The anatomy and physiopathology of the arthrogrypotic articulation are reviewed. The role of biomechanical factors in the development and maintenance of joint surfaces is discussed. Treatment modalities are proposed.

Solitary neurofibroma of the mandible and infratemporal fossa in a young child: Report of a case

The first case of a rare and unusual solitary neurofibroma of the mandible that caused bony erosion and extension into the adjacent soft tissues of the infratemporal fossa is presented. The clinical, radiographic, and histopathologic features of the neurofibroma are reviewed. The diagnostic procedures and the surgical treatment of this tumor in a young child are discussed.

Free mucosal grafts for vestibuloplasty

Abstract Free mucosal grafts for vestibuloplasty were performed on seven dogs of mixed breed. Macroscopic and microscopic findings demonstrated that the grafts were well tolerated and that by the seventeenth day all inflammatory changes had subsided. Vascularization of the graft was complete by the tenth day. Regression was not seen in dogs observed for up to 6 months.

The cancer-promoting effect of N-Nitrosonornicotine used in combination with a subcarcinogenic dose of 4-nitroquinoline-N-oxide and 7, 12-dimethylbenz (A) anthracene

PURPOSE This study was conducted to determine the possible carcinogenic role of N-Nitrosonornicotine (NNN) when combined with subcarcinogenic doses of strong carcinogens dimethylbenz (a) anthracene (DMBA) and 4-nitroquinoline-N-oxide (4NQO) in the hamster cheek pouch. MATERIALS AND METHODS Eighty-five Syrian golden hamsters were randomly divided into three main groups. Group A contained 35 animals, 20 of which were treated with 0.1% DMBA followed by 4% NNN (A-I), 5 with 0.1% DMBA (A-II), 5 with 4% NNN (A-III), and 5 with mineral oil alone (A-IV). Group B contained 23 animals, 13 of which were treated with 0.5% 4NQO followed by 4% NNN (B-I), 5 with 0.5% 4NQO (B-II), and 5 animals with propyleneglycol alone (B-III). Group C contained 27 animals, 14 of which were treated with 0.1% DMBA followed by 4% NNN and 0.5% 4NQC (C-I), and 13 with 0.1% DMBA followed by 0.5% 4NQO (C-II). All animals were treated three times per week for 16 weeks. A total of 7 animals died during this period. RESULTS Squamous cell carcinoma (SCCA) developed in eight animals (67%) in the group treated with all three chemicals (C-I), in four animals (33%) treated with DMBA and 4NQO (C-II), in two animals (15%) treated with 4NQO and NNN (B-I), and in two animals (11%) treated with DMBA and NNN (A-I). The difference between the number of animals that developed carcinoma in group C-I and those in groups A-I and B-I was statistically significant (P < .05) and this difference reached a significant value when group C-I and C-II were compared (P < or = .1). There was a direct relationship between the number of tumors produced in animals and the number of different chemicals applied. CONCLUSION The results of this study indicate that NNN, when combined with subcarcinogenic doses of other strong carcinogens, is a promoter in the development of squamous cell carcinoma and that 4NQO in 0.5% concentration is a stronger carcinogen than 0.1% DMBA.

Traumatic bone cyst in the maxilla

This report presents an unusual asymptomatic periapical radiolucency occurring around the upper right lateral incisor. Surgical intervention revealed an empty bone cavity which was diagnosed as a traumatic bone cyst. Follow-up periapical radiographs of the patient were taken over a 6-year period until complete healing of the lesion took place.

Dens in dente: An unusual sequela: Abbreviated case report

Dens in dente is the result of an invagination of the enamel organ into the developing dental papilla. The full pathologic potential of this lesion is often not fully appreciated. A case is reported in which a cyst resulting from a dens in dente obliterated the maxillary sinus and necessitated root canal therapy and apicoectomies in four adjacent teeth.